3 research outputs found
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A method for performance diagnosis and evaluation of video trackers
Several measures for evaluating multi-target video trackers exist that generally aim at providing âend performance.â End performance is important particularly for ranking and comparing trackers. However, for a deeper insight into trackersâ performance it would also be desirable to analyze key contributory factors (false positives, false negatives, ID changes) that (implicitly or explicitly) lead to the attainment of a certain end performance. Specifically, this paper proposes a new approach to enable a diagnosis of the performance of multi-target trackers as well as providing a means to determine the end performance to still enable their comparison in a video sequence. Diagnosis involves analyzing probability density functions of false positives, false negatives and ID changes of trackers in a sequence. End performance is obtained in terms of the extracted performance scores related to false positives, false negatives and ID changes. In the experiments, we used four state-of-the-art trackers on challenging real-world public datasets to show the effectiveness of the proposed approach
Characterisation of the Cullin-3 mutation that causes a severe form of familial hypertension and hyperkalaemia
Deletion of exon 9 from Cullinâ3 (CUL3, residues 403â459: CUL3Î403â459) causes pseudohypoaldosteronism type IIE (PHA2E), a severe form of familial hyperkalaemia and hypertension (FHHt). CUL3 binds the RING protein RBX1 and various substrate adaptors to form CullinâRINGâubiquitinâligase complexes. Bound to KLHL3, CUL3âRBX1 ubiquitylates WNK kinases, promoting their ubiquitinâmediated proteasomal degradation. Since WNK kinases activate Na/Cl coâtransporters to promote salt retention, CUL3 regulates blood pressure. Mutations in both KLHL3 and WNK kinases cause PHA2 by disrupting CullinâRINGâligase formation. We report here that the PHA2E mutant, CUL3Î403â459, is severely compromised in its ability to ubiquitylate WNKs, possibly due to altered structural flexibility. Instead, CUL3Î403â459 autoâubiquitylates and loses interaction with two important Cullin regulators: the COP9âsignalosome and CAND1. A novel knockâin mouse model of CUL3WT/Î403â459 closely recapitulates the human PHA2E phenotype. These mice also show changes in the arterial pulse waveform, suggesting a vascular contribution to their hypertension not reported in previous FHHt models. These findings may explain the severity of the FHHt phenotype caused by CUL3 mutations compared to those reported in KLHL3 or WNK kinases
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The future of video analytics for surveillance and its ethical implications
The current state of the art and direction of research in computer vision aimed at automating the analysis of CCTV images is presented. This includes low level identification of objects within the field of view of cameras, following those objects over time and between cameras, and the interpretation of those objectsâ appearance and movements with respect to models of behaviour (and therefore intentions inferred). The potential ethical problems (and some potential opportunities) such developments may pose if and when deployed in the real world are presented, and suggestions made as to the necessary new regulations which will be needed if such systems are not to further enhance the power of the surveillers against the surveilled