972 research outputs found
Bioinformatics Approach for Functional Glycomics
Presentation in the Human Glycomics Proteomics Disease Initiative (HGPI) session
Financial services for the urban poor : South Africa's E Plan
Much of the research on financial services in low-income countries has focused on micro-credit programs. Much less attention has been paid to the design of depository services, although many more low-income people use depository services than get access to credit. Having access to depository services is important for household well-being: to safeguard funds, to save for large purchases, and as insurance against unexpected expenditures. Economic reform programs in recent years have encouraged banks to push up nominal interest rates to keep deposit rates positive in real terms, and to motivate savings in financial assets. But once deposit rates are positive in real terms, banks typically increase minimum deposit size or find other ways to discourage small depositors because of the high costs of maintaining and servicing low-balance accounts. Traditional passbook savings accounts, the main product used by low-income households, are being phased out because of high costs. After South Africa's move to democracy in 1994, it was politically imperative that the country's major financial institutions help redress the historically weak system of services for low-income people. The authors describe one of the more interesting experiments. In 1993 Standard Bank of South Africa created an affiliate, called E Bank, to deliver basic banking services to the urban poor. E Bank provides a package of financial services designed specifically for low-income clients, offering greater convenience for the user while keeping under control the costs to the bank of providing services. E Bank combines the innovative technology of modified ATM services with staff available to help all clients. By rethinking the needs of the basic banking customer, E Bank was able to bundle services valued by poorer clients to justify a fee high enough to cover costs.Fiscal&Monetary Policy,Payment Systems&Infrastructure,Banks&Banking Reform,Health Economics&Finance,Environmental Economics&Policies,Banks&Banking Reform,Health Economics&Finance,Payment Systems&Infrastructure,Environmental Economics&Policies,Economic Theory&Research
Multivalent ligands of CD22 for targeting of B cells
Multivalent ligands of CD22 for active targeting of B cells. Mary O’Reilly, Wei Hsu Chen, Gladys Completo, Ying Zeng, Satoshi Futakawa and Cory Rillahan and James C. Paulson, Departments of Chemical Physiology and Molecular Biology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA, 92037

The siglecs comprise 13 members of the immunoglobulin superfamily that recognize sialic acid containing glycans, and are differentially expressed on leukocytes and glial cells. The natural ligands of siglecs typically occur on the same cell (in cis) and/or on adjacent cells (in trans). Cis ligands mask the binding of multivalent synthetic sialoside ligands and are thought to regulate the activity of siglecs as modulators of cell signaling. However, synthetic ligands of sufficient avidity can compete with cis ligands, demonstrating a dynamic equilibrium of cis and trans ligand probes. We have explored the relationship between valency, affinity and geometry for achieving avidity sufficient to compete with cis ligands of CD22 (Siglec-2) in situ. A notable achievement is a hetero-bifunctional ligand approach to create multivalent ligands using antibodies as a protein scaffold. The ligand is comprised of a CD22 ligand, 9-biphenylcarboxyl-NeuAcα2-6Galβ1-4GlcNAc (BPCNeuAc), coupled to an antigen, 4-hydroxy-3-nitrophenylacetic acid (NP) (BPCNeuAc-NP). The BPCNeuAc-NP ligand is able to efficiently assemble complexes of anti-NP antibodies with CD22 on both asialo- and native B cells. Surprisingly, assembly of the tertiary complex occurs with anti-NP IgM (n=10), IgA (n=4) and IgG (n=2). The results suggest that spacing of ligands using an antibody optimizes the contribution of geometry to achieve high avidity with low valency. Other multivalent configurations also show promise for targeting B cells. In particular, liposomes bearing BPCNeuAc ligands bind avidly to B cells and are endocytosed. Thus, BPCNeuAc-lipososomes may prove effective in delivery of therapeutic agents to B cells (Supported by NIH grants GM60938, AI50143 ).

Of PDRs and Precedent
This Texas Lawyer Legal Research column article discusses the Texas Court of Criminal Appeals’ use of discretionary review powers to discourage out-of-staters from setting up a law practice in Texas and the true anniversary date of the Texas Court of Criminal Appeals
Of PDRs and Precedent
This Texas Lawyer Legal Research column article discusses the Texas Court of Criminal Appeals’ use of discretionary review powers to discourage out-of-staters from setting up a law practice in Texas and the true anniversary date of the Texas Court of Criminal Appeals
A comparison of three heuristics to choose the variable ordering for CAD
Cylindrical algebraic decomposition (CAD) is a key tool for problems in real
algebraic geometry and beyond. When using CAD there is often a choice over the
variable ordering to use, with some problems infeasible in one ordering but
simple in another. Here we discuss a recent experiment comparing three
heuristics for making this choice on thousands of examples
De Novo Pudendal Neuropathy After TOT-O Surgery for Stress Urinary Incontinence
Complications from needle placement and exit during a TOT procedure exist and must be considered when placing the needle through the area of the obturator fossa
Southwestern Minnesota Farm Business Management Association 2008 Annual Report
Average net farm income was 242,267 in 2007 (Figure 1). 2008 ended a steady trend of increasing year-to-year incomes for these farms from 2001 to 2007. Crop farms, with historically high corn and soybean prices, remained very profitable. However, specialized hog farms, which had been very profitable for the past four years, experienced substantial losses. Highlights of association financial results for 2008: Median net farm income was 449,997 while the least profitable lost 115,999. The average debt-to-asset ratio improved slightly to 39%, down from 40% (Figure 4). • Corn yields were up but soybean yields were down. Corn averaged 172 bushels per acre compared to 162 in 2007. Soybeans yields decreased to 44 bushels from 49 in 2007 (Figure 5). • Both corn and soybean prices received increased by over 50% to 10.83 for soybeans. • The cost to raise an acre of corn (with land rent) increased by 23% while soybean costs increased by 21%. The cost to produce a bushel of corn on cash rented land increased from 2.90 in 2008, while soybean costs per bushel increased from 7.21. • The average specialized hog operation (those with 70% of sales from hogs or pigs) lost over 1,000,000, were the least profitable based on rate of return on assets. This group earned an average ROA of 7% compared to 14% for farms that grossed between 1,000,000. • With exceptionally high feed prices, no hog or beef enterprise, with the exception of contract growing of hogs (where the contractor provided the feed) covered even direct costs of production. The report provides additional information on profitability, liquidity, and solvency as well as other whole-farm information and detailed information on crop and livestock enterprises. Also reported are whole-farm financial condition and performance by county, sales size class, type of farm, debt-to-asset ratio, and age of operator.Agricultural Finance, Farm Management,
Broad Autism Phenotypic Traits and the Relationship to Sexual Orientation and Sexual Behavior
Individuals with higher levels of the broad autism phenotype (BAP) have some symptoms of autism spectrum disorder (ASD). Like individuals with ASD, people with higher-BAP may have fewer sexual experiences and may experience more same-sex attraction. This study measured BAP traits, sexual experiences, and sexual orientation in typically developing (TD) individuals to see if patterns of sexual behavior and sexual orientation in higher-BAP resemble those in ASD. Although BAP characteristics did not predict sexual experiences, one BAP measure significantly predicted sexual orientation, β = 0.22, t = 2.72, p = .007, controlling for demographic variables (R2 change = .04, F = 7.41, p = .007), showing individuals with higher-BAP also reported increased same-sex attraction. This finding supports the hypothesis that individuals with higher-BAP resemble ASD individuals in being more likely than TD individuals to experience same-sex attraction
Using Machine Learning to Decide When to Precondition Cylindrical Algebraic Decomposition With Groebner Bases
Cylindrical Algebraic Decomposition (CAD) is a key tool in computational algebraic geometry, particularly for quantifier elimination over real-closed fields. However, it can be expensive, with worst case complexity doubly exponential in the size of the input. Hence it is important to formulate the problem in the best manner for the CAD algorithm. One possibility is to precondition the input polynomials using Groebner Basis (GB) theory. Previous experiments have shown that while this can often be very beneficial to the CAD algorithm, for some problems it can significantly worsen the CAD performance.In the present paper we investigate whether machine learning, specifically a support vector machine (SVM), may be used to identify those CAD problems which benefit from GB preconditioning. We run experiments with over 1000 problems (many times larger than previous studies) and find that the machine learned choice does better than the human-made heuristic
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