Questioning the Logic of Broken Windows: Some People “See” More Local Incivilities than Others

Many attribute New York’s massive fall in crime that began in the early 1990s to the implementation of the “broken windows” policing policy that sought to reduce “incivilities” – the social and physical indicators of neighborhood deterioration. In new research, Nathan W. Link and James M. Kelly examine the common wisdom that urban incivility leads to fear of crime. They argue that some people can be more “tuned in” to incivilities in their environment than others, and that those who are more generally fearful perceive greater incivilities

Fostering University-Industry R&D Collaborations in European Union Countries

This paper advances our understanding of university-industry research and development (R&D) collaborations. These strategic relationships are a dimension of entrepreneurial activity, and they are thus important drivers of economic growth and development. Business collaboration with universities increases the efficiency and effectiveness of industrial investments. Previous studies have found that universities are more likely to collaborate with industry if the business is mature and large, is engaged in exploratory internal R&D, and there are not major intellectual property (IP) issues between both parties. Businesses gain from such collaborations through increased commercialisation probabilities and economies of technological scope. Based on publicly available data collected by the Science-to-Business Marketing Research Centre of Germany as part of a European Commission project, our paper focuses on two key questions. First, why are there cross-country differences in the extent to which universities collaborate with business in R&D? Second, are there covariates with these differences that might offer insight into policy prescriptions and policy levers for enhancing the extent to which such collaboration takes place? We find that access is positive and statistically significant in relation to fostering university-business R&D collaborations. Our results, albeit that they are tempered by a small sample of data, have implications how national innovation systems support further harmonization of IP regimes across universities and how universities prioritise their own investments and incentives

Cell Surface Labeling of Escherichia coli via Copper(I)-Catalyzed [3+2] Cycloaddition

Labeling of the cell surface of Escherichia coli was accomplished by expression of a recombinant outer membrane protein, OmpC, in the presence of the unnatural amino acid azidohomoalanine, which acts as a methionine surrogate. The surface-exposed azide moieties of whole cells were biotinylated via Cu(1)-catalyzed [3+2] azide-alkyne cycloaddition. The specificity of labeling of both wild-type OmpC and a mutant containing additional methionine sites for azidohomoalanine incorporation was confirmed by Western blotting. Flow cytometry was performed to examine the specificity of the labeling. Cells that express the mutant form of OmpC in the presence of azidohomoalanine, which were biotinylated and stained with fluorescent avidin, exhibit a mean fluorescence 10-fold higher than the background. Incorporation of an unnatural amino acid can thus be determined on a single-cell basis

Introduction of an Aliphatic Ketone into Recombinant Proteins in a Bacterial Strain that Overexpresses an Editing-Impaired Leucyl-tRNA Synthetase

Like leucine? A leucine analogue containing a ketone has been incorporated into proteins in E. coli. Only E. coli strains overexpressing an editing-deficient leucyl-tRNA synthetase were capable of synthesizing proteins with the aliphatic ketone amino acid. Modification of ketone-containing proteins under mild conditions has been demonstrated

A photonic crystal cavity-optical fiber tip nanoparticle sensor for biomedical applications

We present a sensor capable of detecting solution-based nanoparticles using an optical fiber tip functionalized with a photonic crystal cavity. When sensor tips are retracted from a nanoparticle solution after being submerged, we find that a combination of convective fluid forces and optically-induced trapping cause an aggregation of nanoparticles to form directly on cavity surfaces. A simple readout of quantum dot photoluminescence coupled to the optical fiber shows that nanoparticle presence and concentration can be detected through modified cavity properties. Our sensor can detect both gold and iron oxide nanoparticles and can be utilized for molecular sensing applications in biomedicine.Comment: 13 pages, 5 figure

Latent technology as an outcome of R&D

This paper focuses on a situation in which a firm decides to sell its non-commercialized technology to another firm rather than commercialize it (a latent entrepreneurial firm), and the other firm then adopts the appearance of an emergent entrepreneur. Using U.S. project data from firms funded through the U.S. Small Business Innovation Research (SBIR) program, we find using a qualitative choice model that firms that do not commercialize their newly developed SBIR-funded technology have a greater probability of selling their technology to another firm. We also identify other covariates with the probability that such a firm will sell their technology

A Straight Path: Studies in Medieval Philosophy and Culture; Essays in Honor of Arthur Hyman

R. James Long is a co-editor as well as a contributing author, Richard Fishacre\u27s Way to God pp. 174-82. Book description: Collected to honor the scholarship of Arthur Hyman over the past thirty years, the twenty-three articles of this volume are original contributions by established scholars of medieval philosophy. . . --Journal of the History of Philosophyhttps://digitalcommons.fairfield.edu/philosophy-books/1001/thumbnail.jp

Simulated Performance of 3-DTI Gamma-Ray Telescope Concepts

We present Monte Carlo simulations of two astronomical gamma-ray telescope concepts based on the ThreeDimensional Track Imager (3- DTI) detector. The 3-DTI consists of a time projection chamber with two-dimensional, crossedstrip micro-well detector readout. The full three- dimensional reconstruction of charged-particle tracks in the gas volume is obtained from transient digitizers, which record the time signature of the charge collected in the wells of each strip. Such detectors hold great promise for advanced Compton telescope (ACT) and advanced pair telescope (APT) concepts due to the very precise measurement of charged particle momenta that is possible (Compton recoil electrons and electron-positron pairs, respectively). We have investigated the performance of baseline ACT and APT designs based on the 3-DTI detector using simulation tools based on GEANT3 and GEANT4, respectively. We present the expected imaging, spectroscopy, polarimetry, and background performance of each design