Trust in Biotechnology Risk Managers: Insights from the United Kingdom, 1996-2002

The mid to late 1990s saw a series of negative media events in the United Kingdom (UK) related to biotechnology. According to the trust asymmetry hypothesis, such events ought to cause public trust in risk managers of biotechnology to fall quickly but rise slowly. We present evidence from the Eurobarometer surveys that from 1996 to 1999 public trust in the UK declined, but it increased sharply between 1999 and 2002. We seek to explain this apparent contradiction to the asymmetry hypothesis. We use canonical discriminant analysis of public trust to show that whether people trust or distrust risk managers of biotechnology depends significantly on the amount of knowledge people have about science. We speculate that knowledge of science moderates the trust asymmetry effect.Research and Development/Tech Change/Emerging Technologies,

Trust in Biotechnology Risk Managers: Insights from the United Kingdom, 1996-2002

During the late 1990s a series of negative events occurred in the United Kingdom (UK) related to biotechnology. These events signaled potential risks associated with biotech foods and crops and were highly reported. According to the trust asymmetry hypothesis, such events ought to cause public trust in risk managers of biotechnology to decline rapidly and rebound more slowly. We find, based on data taken from the Eurobarometer surveys conducted in 1996, 1999 and 2002, that public trust in risk managers did decline from 1996 to 1999. However, the level of trust rebounded sharply between 1999 and 2002. Canonical discriminant analysis of public trust is used to reveal possible explanatory factors in this response. We find that whether people trust or distrust risk managers depends significantly on the amount of objective knowledge they have. We argue that knowledge of science might moderate the trust asymmetry effect.Research and Development/Tech Change/Emerging Technologies, Risk and Uncertainty,

One lumbar extension training session per week is sufficient for strength gains and reduction in pain in patients with chronic low back pain ergonomics

Chronic low back pain (CLBP) is the leading cause of absenteeism from the workplace and research into exercise interventions to address this problem is required. This study investigated training frequency for participants with CLBP. Participants either trained once a week (1 × week, n = 31), or twice a week (2 × week, n = 20) or did not (control group, n = 21). Participants were isometric strength tested in weeks 1 and 12 and trained dynamically either 1×week (80% of maximum) or 2×week (80% and 50%). The results (pre vs. post) showed significant increases in maximal strength, range of motion and reductions in pain for both training groups. Pain scores for the 1 × week and 2 × week both reached minimal clinical improvement change unlike the control group. Thus, one lumbar extension training session per week is sufficient for strength gains and reductions in pain in low back pain in CLBP patients

‘I was no “master of this work” but a servant to it’? William Laud, Charles I and the making of Scottish ecclesiastical policy, 1634-6

Building upon recent scholarship, this article presents a study of policy formation within the composite monarchy of Charles I. Through a scrutiny of the 1636 canons – a crucial but neglected aspect of the ‘Laudian’ programme in Scotland – new light is shed on the contested dynamics of the working partnership between the king and William Laud, archbishop of Canterbury (1633–45). The article also engages with the question of whether Laud can accurately be described as ‘the master’ of religious reform in Scotland and contends that he recast retrospectively his role in policy formation – not just in the canons, but in other, equally controversial, aspects of Scottish policy – thus concealing the true extent of his involvement, by presenting himself as having been a servant, not an agent. Suggesting greater involvement in Scottish affairs than has hitherto been acknowledged, these findings put Laud at the heart of a programme of religious reform that extended across the British churches during the sixteen-thirties

QIS: a new participatory management tool to assess and act on field reality

One of the main problems to assess the achievement of the MDGs is the paucity of reliable data and statistics that reflect field reality, especially of the poor. With successive waves of decentralisation, district authorities have been made responsible for poverty and gender specific information on coverage, use and sustainability of water and sanitation services, at community level and district levels. Participatory methods are essential to give all members of village communities the opportunity to influence scores, and also to make informed choices during planning, and control quality of implementation. However, such methods are time consuming and often generate qualitative information that is difficult to compare and analyse at district or national levels. To address these problems, IRC developed, together with the Water and Sanitation Program (WSP), the Methodology for Assessment (MPA) to assess sustainability of services and to generate gender and poverty specific data. (Mukherjee and van Wijk, 2003). Based on the methodology, IRC along with AJ James has now developed Qualitative Information System (QIS), which is a flexible system to store and analyse qualitative data for monitoring progress and adaptive management at both project and community levels. Although QIS has the potential to contribute to a more effective use of qualitative information, the challenges of preserving quality when using participatory methods as well as the reliability of the data collected remain concerns to be addressed. The paper presents a number of key concerns and introduces a set of criteria to ensure quality of both the participatory processes and the data collected

Adverse childhood experiences, non-response and loss to follow-up: Findings from a prospective birth cohort and recommendations for addressing missing data

Adverse childhood experiences have wide-ranging impacts on population health but are inherently difficult to study. Retrospective self-report is commonly used to identify exposure but adult population samples may be biased by non-response and loss to follow-up. We explored the implications of missing data for research on child abuse and neglect, domestic violence, parental mental illness and parental substance use. Using 15 waves of data collected over 28 years in a population-based birth cohort, the Australian Temperament Project, we examined the relationship between retrospective self-reports of adverse childhood experiences and parent- and cohort-responsiveness at other time points. We then compared prevalence estimates under complete case analysis, inverse probability-weighting using baseline auxiliary variables, multiple imputation using baseline auxiliary variables, multiple imputation using auxiliary variables from all waves, and multiple imputation using additional measures of participant responsiveness. Retrospective self-reports of adverse childhood experiences were strongly associated with non-response by both parents and cohort members at all observable time points. Biases in complete case estimates appeared large and inverse probability-weighting did not reduce them. Multiple imputation increased the estimated prevalence of any adverse childhood experiences from 30.0% to 36.9% with only baseline auxiliary variables, 39.7% with a larger set of auxiliary variables and 44.0% when measures of responsiveness were added. Close attention must be paid to missing data and non-response in research on adverse childhood experiences as data are unlikely to be missing at random. Common approaches may greatly underestimate their prevalence and compromise analysis of their causes and consequences. Sophisticated techniques using a wide range of auxiliary variables are critical in this field of research, including, where possible, measures of participant responsiveness.Funding for this analysis was supported by a PhD scholarship from the University of South Australia, and the South Australian Health Economics Collaborative (funded by the South Australian Department of Health)

Mivacurium Sensitivity at the Adductor Pollicis and Hand Grip Muscles: Differences Between Males and Females

Background: Males lose more handgrip strength (HGS) than females when adductor pollicis (AP) TOF ratio decreases. The reason is unclear. Objectives: The primary aim of this study was to explore gender-related differences in neuromuscular sensitivity to mivacurium. As a secondary aim, clearance of mivacurium was determined. Methods: In 10 healthy males and 10 healthy females, constant-rate infusions of mivacurium were administered to obtain three different levels of stable neuromuscular block (normalized acceleromyography AP TOF ratio 80, 60, and 40%) in each study subject. Arterial blood samples were collected to determine mivacurium plasma concentrations. The HGS was measured every five minutes. A Hill equation was fitted to data on mivacurium concentration versus normalized AP TOF ratio and HGS to determine drug concentrations associated with 50% maximum effect (C50 AP TOF ratio and C50 HGS). Differences within and between genders were tested with the parametric t-test. Clearance of mivacurium was calculated at each block level as the ratio between drug infusion  rate and concentration. Gender-related differences in relationships between AP TOF ratio and HGS, mivacurium infusion rates, and mivacurium plasma concentrations were determined with linear mixed-models. Results: The C50 AP TOF ratio was significantly greater than C50HGSin males, yet not in females. Mivacurium infusion rates, needed to maintain stable neuromuscular blocks, were significantly greater in males, while clearance was similar between genders. Males lost significantly more HGS with decreasing AP TOF ratio than females, both in absolute (kg) and relative (percentage of baseline) terms. Conclusions: In males, yet not in females, the AP was significantly less sensitive to the effect of mivacurium than the muscles involved in the handgrip function. Thisfindingexplainswhyhandgripstrength decreasesmorein males than females with decreasing AP TOF ratio during the mivacurium block