4 research outputs found
Interindividual responses of appetite to acute exercise: a replicated crossover study
Purpose: Acute exercise transiently suppresses appetite, which coincides with alterations in appetite-regulatory hormone concentrations. Individual variability in these responses is suspected, but replicated trials are needed to quantify them robustly. We examined the reproducibility of appetite and appetite-regulatory hormone responses to acute exercise and quantified the individual differences in responses. Methods: Fifteen healthy, recreationally-active men completed two control (60-min resting) and two exercise (60-min fasted treadmill running at 70% peak oxygen uptake) conditions in randomised sequences. Perceived appetite and circulating concentrations of acylated ghrelin and total peptide YY (PYY) were measured immediately before and after the interventions. Inter-individual differences were explored by correlating the two sets of response differences between exercise and control conditions. Within-participant covariate-adjusted linear mixed models were used to quantify participant-by-condition interactions. Results: Compared with control, exercise suppressed mean acylated ghrelin concentrations and appetite perceptions (all ES = 0.62 to 1.47, P < 0.001), and elevated total PYY concentrations (ES = 1.49, P < 0.001). For all variables, the SD of the change scores was substantially greater in the exercise versus control conditions. Moderate-to-large positive correlations were observed between the two sets of control-adjusted exercise responses for all variables (r = 0.54 to 0.82, P ≤ 0.036). After adjusting for baseline measurements, participant-by-condition interactions were present for all variables (P ≤ 0.053). Conclusion: Our replicated cross-over study allowed, for the first time, the interaction between participant and acute exercise response in appetite parameters to be quantified. Even after adjustment for individual baseline measurements, participants demonstrated individual differences in perceived appetite and hormone responses to acute exercise bouts beyond any random within-subject variability over time
Effect of obesity-linked FTO rs9939609 variant on physical activity and dietary patterns in physically active men and women
Single nucleotide polymorphisms (SNPs) in the fat mass and obesity-associated (FTO) locus are associated with obesity, but lifestyle factors may modulate the obesity risk related to FTO. This study examined the physical activity and dietary patterns of 528 physically active white men and women (mean(SD): 34.9(9.5) years, 26.6(4.3) kg·m-2) carrying different risk variants of the FTO SNP rs9939609. Sex, age and anthropometric measurements (stature, body mass, waist circumference) were self-reported using an online questionnaire, and body mass index and waist-to-height ratio were calculated. Physical activity and eating behaviour were assessed using the International Physical Activity Questionnaire and Three-Factor Eating Questionnaire (TFEQ), respectively. Body mass, body mass index, waist circumference and waist-to-height ratio were not significantly different between individuals expressing different FTO rs9939609 risk variants (all P≥0.66). The cohort was physically active (4516 (3043) total MET min·week-1), although homozygous risk allele carriers (AA) displayed higher TFEQ cognitive restraint compared with non-risk allele carriers (TT) (ES=0.33, P=0.03). In conclusion, obesity-related parameters were not different in physically active individuals expressing different risk variants of FTO rs9939609, although homozygous risk allele carriers exhibited higher cognitive restraint
The effects of sprint interval exercise training on hepatic and peripheral insulin sensitivity (IS), as well as intrahepatic triglyceride (IHTG), in men with nonalcoholic fatty liver disease (NAFLD) [Abstract]
The effects of sprint interval exercise training on hepatic and peripheral insulin sensitivity (IS), as well as intrahepatic triglyceride (IHTG), in men with nonalcoholic fatty liver disease (NAFLD) [Abstract
Exploration of associations between the FTO rs9939609 genotype, fasting and postprandial appetite-related hormones and perceived appetite in healthy men and women
Background: The fat mass and obesity-associated gene (FTO) rs9939609 A-allele has been
associated with obesity risk. Although the exact mechanisms involved remain unknown, the FTO
rs9939609 A-allele has been associated with an impaired postprandial suppression of appetite.
Objectives: To explore the influence of FTO rs9939609 genotype on fasting and postprandial
appetite-related hormones and perceived appetite in a heterogeneous sample of men and women.
Design: 112 healthy men and women aged 18-50-years-old completed three laboratory visits for
the assessment of FTO rs9939609 genotype, body composition, aerobic fitness, resting
metabolic rate, visceral adipose tissue, liver fat, fasting leptin, and fasting and postprandial
acylated ghrelin, total PYY, insulin, glucose and perceived appetite. Participants wore
accelerometers for seven consecutive days for the assessment of physical activity and sedentary
behaviour. Multivariable general linear models quantified differences between FTO rs9939609
groups for fasting and postprandial appetite outcomes, with and without the addition of a priori
selected physiological and behavioural covariates. Sex-specific univariable Pearson’s correlation
coefficients were quantified between the appetite-related outcomes and individual characteristics.
Results: 95% confidence intervals for mean differences between FTO rs9939609 groups
overlapped zero in unadjusted and adjusted general linear models for all fasting (P≥0.28) and
postprandial (P≥0.19) appetite-related outcomes. Eta2 values for explained variance attributable
to FTO rs9939609 were <5% for all outcomes. An exploratory correlation matrix indicated that
associations between fasting and postprandial acylated ghrelin, total PYY and general or
abdominal adiposity were also small (r = -0.23 to 0.15, P≥0.09). Fasting leptin, glucose and
insulin and postprandial insulin concentrations were associated with adiposity outcomes (r =
0.29 to 0.81, P≤0.033). Conclusions: Associations between the FTO rs9939609 genotype and
fasting or postprandial appetite-related outcomes were weak in healthy men and women