3 research outputs found
Feasibility of incorporating genomic knowledge into electronic medical records for pharmacogenomic clinical decision support
In pursuing personalized medicine, pharmacogenomic (PGx) knowledge may help guide prescribing drugs based on a personâs genotype. Here we evaluate the feasibility of incorporating PGx knowledge, combined with clinical data, to support clinical decision-making by: 1) analyzing clinically relevant knowledge contained in PGx knowledge resources; 2) evaluating the feasibility of a rule-based framework to support formal representation of clinically relevant knowledge contained in PGx knowledge resources; and, 3) evaluating the ability of an electronic medical record/electronic health record (EMR/EHR) to provide computable forms of clinical data needed for PGx clinical decision support. Findings suggest that the PharmGKB is a good source for PGx knowledge to supplement information contained in FDA approved drug labels. Furthermore, we found that with supporting knowledge (e.g. IF age <18 THEN patient is a child), sufficient clinical data exists in University of Washingtonâs EMR systems to support 50% of PGx knowledge contained in drug labels that could be expressed as rules