The Origin of Radio Emission in Low-Luminosity Active Galactic Nuclei: Jets, Accretion Flows, or Both?

The low-luminosity active galactic nuclei in NGC 3147, NGC 4203, and NGC 4579 have been imaged at four frequencies with the Very Long Baseline Array. The galaxies are unresolved at all frequencies, with size upper limits of $10^3-10^4$ times the Schwarzschild radii of their central massive black holes. The spectral indices between 1.7 and 5.0 GHz range from 0.2 to 0.4; one and possibly two of the galaxies show spectral turnovers between 5.0 and 8.4 GHz. The high brightness temperatures ($> 10^9$ K) and relatively straight spectra imply that free-free emission and/or absorption cannot account for the slightly inverted spectra. Although the radio properties of the cores superficially resemble predictions for advection-dominated accretion flows, the radio luminosities are too high compared to the X-ray luminosities. We suggest that the bulk of the radio emission is generated by a compact radio jet, which may coexist with a low radiative efficiency accretion flow.Comment: To appear in ApJ (Letters). 4 page

Radio Emission from the Intermediate-mass Black Hole in the Globular Cluster G1

We have used the Very Large Array (VLA) to search for radio emission from the globular cluster G1 (Mayall-II) in M31. G1 has been reported by Gebhardt et al. to contain an intermediate-mass black hole (IMBH) with a mass of ~2 x 10^4 solar masses. Radio emission was detected within an arcsecond of the cluster center with an 8.4 GHz power of 2 x 10^{15} W/Hz. The radio/X-ray ratio of G1 is a few hundred times higher than that expected for a high-mass X-ray binary in the cluster center, but is consistent with the expected value for accretion onto an IMBH with the reported mass. A pulsar wind nebula is also a possible candidate for the radio and X-ray emission from G1; future high-sensitivity VLBI observations might distinguish between this possibility and an IMBH. If the radio source is an IMBH, and similar accretion and outflow processes occur for hypothesized ~ 1000-solar-mass black holes in Milky Way globular clusters, they are within reach of the current VLA and should be detectable easily by the Expanded VLA when it comes on line in 2010.Comment: ApJ Letters, accepted, 11 pages, 1 figur

A Search for Active Galactic Nuclei in Sc Galaxies with H II Spectra

(Abridged) We have searched for nuclear radio emission from a statistically complete sample of 40 Sc galaxies within 30 Mpc that are optically classified as star-forming objects, in order to determine whether weak AGNs might be present. Only three nuclear radio sources were detected, in NGC 864, NGC 4123, and NGC 4535. These galaxies have peak 6-cm radio powers of 10^{20} W/Hz at arcsecond resolution, while upper limits of the non-detected galaxies typically range from 10^{18.4} to 10^{20} W/Hz. The three nuclear radio sources all are resolved and appear to have diffuse morphologies, with linear sizes of ~300 pc. This strongly indicates that circumnuclear star formation has been detected in these three H II galaxies. Comparison with previous 20-cm VLA results for the detected galaxies shows that the extended nuclear radio emission has a flat spectrum in two objects, and almost certainly is generated by thermal emission from gas ionized by young stars in the centers of those galaxies. The 6-cm radio powers are comparable to predictions for thermal emission that are based on the nuclear H-alpha luminosities, and imply nuclear star formation rates of 0.08-0.8 solar masses/yr, while the low-resolution NRAO VLA Sky Survey implies galaxy-wide star formation rates of 0.3-1.0 solar masses/yr in stars above 5 solar masses. Although the presence of active nuclei powered by massive black holes cannot be definitively ruled out, the present results suggest that they are likely to be rare in these late-type galaxies with H II spectra.Comment: To appear in ApJ. 7 page

Novel Small Leucine-Rich Protein Chondroadherin-like (CHADL) is Expressed in Cartilage and Modulates Chondrocyte Differentiation.

The constitution and biophysical properties of extracellular matrices can dramatically influence cellular phenotype during development, homeostasis, or pathogenesis. These effects can be signaled through a differentially regulated assembly of collagen fibrils, orchestrated by a family of collagen-associated Small Leucine-Rich Proteins, SLRPs. In this report, we describe the tissue-specific expression and function of a previously uncharacterized SLRP Chondroadherin-like (CHADL). We have developed antibodies against CHADL and, by immunohistochemistry, detected CHADL expression mainly in skeletal tissues, particularly in fetal cartilage and in pericellular space of adult chondrocytes. In situ hybridizations and immunoblots on tissue lysates confirmed this tissue-specific expression pattern. Recombinant CHADL bound collagen in cell culture, and inhibited in vitro collagen fibrillogenesis. After Chadl shRNA knockdown chondrogenic ATDC5 cells increased their proliferation and differentiation, indicated by increased transcript levels of Sox9, Ihh, Col2a1, and Col10a1. The knockdown increased collagen II and aggrecan deposition in the cell layers. Microarray analysis of the knockdown samples suggested collagen receptor-related changes, although other upstream effects could not be excluded. Together, our data indicate that the novel SLRP CHADL is expressed in cartilaginous tissues, influences collagen fibrillogenesis, and modulates chondrocyte proliferation and differentiation. CHADL appears to have a negative regulatory role, possibly ensuring the formation of a stable extracellular matrix

Capecitabine as Salvage Treatment for Lymphoepithelioma-Like Carcinoma of Lung

AbstractLymphoepithelioma-like carcinoma (LELC) of lung has previously demonstrated good clinical response to 5-fluorouracil containing chemotherapy regimen, similar to the observation in undifferentiated nasopharyngeal carcinoma. Capecitabine, which is converted into active 5-fluorouracil within tumor cells, has been found effective in colorectal, breast, and recently nasopharyngeal carcinomas. We report our experience in five patients with advanced or metastatic LELC of lung who were treated with single agent capecitabine as salvage chemotherapy. The finding of disease control in three of five patients, especially with exceptionally durable stable disease (14.8 months) in one patient, suggests the potential clinical activity of capecitabine in LELC of lung. Future studies on capecitabine-containing chemotherapy regimens in LELC of lung are warranted

The Radio Quiescence of Active Galaxies with High Accretion Rates

We present 6 cm Very Large Array observations of the Greene & Ho (2004) sample of 19 low-mass active galaxies with high accretion rates. This is one of the only studies of a uniform sample of narrow-line Seyfert 1 (NLS1) galaxies with such high sensitivity and resolution. Although we detect only one source, the entire sample is very radio-quiet down to strong limits. GH10 was found to have a radio power of 8.5 x 10^21 W/Hz, and a ratio R = f(6 cm)/f(4400 A) of 2.8. The 3 sigma upper limits for the remaining nondetections correspond to radio powers from 3 x 10^20 to 8 x 10^21 W/Hz and 0.47 < R <9.9. Stacking all nondetections yields an even stronger upper limit of R < 0.27. An assessment of existing observations in the literature confirms our finding that NLS1s are consistently radio-quiet, with a radio-loud fraction of 0%-6%, which is significantly lower than the 10%-20% observed in the general quasar population. By analogy with stellar-mass black holes, we argue that AGNs undergo a state transition at L_bol/L_Edd~0.01. Below this value a radiatively inefficient accretion flow effectively drives an outflow, which disappears when the flow turns into an optically thick, geometrically thin disk, or a radiation pressure-dominated slim disk at still higher L_bol/L_Edd.Comment: To appear in ApJ; 8 pages, 3 figures; uses emulateapj5.st

Tomography of X-ray Nova Muscae 1991: Evidence for ongoing mass transfer and stream-disc overflow

We present a spectroscopic analysis of the black hole binary Nova Muscae 1991 in quiescence using data obtained in 2009 with MagE on the Magellan Clay telescope and in 2010 with IMACS on the Magellan Baade telescope at the Las Campanas Observatory. Emission from the disc is observed in H alpha, H beta and Ca II (8662 A). A prominent hotspot is observed in the Doppler maps of all three emission lines. The existence of this spot establishes ongoing mass transfer from the donor star in 2009-2010 and, given its absence in the 1993-1995 observations, demonstrates the presence of a variable hotspot in the system. We find the radial distance to the hotspot from the black hole to be consistent with the circularization radius. Our tomograms are suggestive of stream-disc overflow in the system. We also detect possible Ca II (8662 A) absorption from the donor star.Comment: 10 pages, 11 figures, 1 table. Accepted for publication in MNRA

Assessment of Artifacts and Reproducibility across Spectral- and Time-Domain Optical Coherence Tomography Devices

Purpose To report the frequency of optical coherence tomography (OCT) scan artifacts and to compare macular thickness measurements, interscan reproducibility, and interdevice agreeability across 3 spectral-domain (SD) OCT (also known as Fourier domain; Cirrus HD-OCT, RTVue-100, and Topcon 3D-OCT 1000) devices and 1 time-domain (TD) OCT (Stratus OCT) device. Design Prospective, noncomparative, noninterventional case series. Participants Fifty-two patients seen at the New England Eye Center, Tufts Medical Center Retina Service, between February and August 2008. Methods Two scans were performed for each of the SD OCT protocols: Cirrus macular cube 512×128 (software version 3.0; Carl Zeiss Meditec, Inc., Dublin, CA), RTVue (E)MM5 and MM6 (software version 3.5; Optovue, Inc., Fremont, CA), Topcon 3D Macular and Radial (software version 2.12; Topcon, Inc., Paramus, NJ), in addition to 1 TD OCT scan via Stratus macular thickness protocol (software version 4.0; Carl Zeiss Meditec, Inc.). Scans were inspected for 6 types of OCT scan artifacts and were analyzed. Interscan reproducibility and interdevice agreeability were assessed by intraclass correlation coefficients (ICCs) and Bland-Altman plots, respectively. Main Outcome Measures Optical coherence tomography image artifacts, macular thickness, reproducibility, and agreeability. Results Time-domain OCT scans contained a significantly higher percentage of clinically significant improper central foveal thickness (IFT) after manual correction (11-μm change or more) compared with SD OCT scans. Cirrus HD-OCT had a significantly lower percentage of clinically significant IFT (11.1%) compared with the other SD OCT devices (Topcon 3D, 20.4%; Topcon Radial, 29.6%; RTVue (E)MM5, 42.6%; RTVue MM6, 24.1%; P = 0.001). All 3 SD OCT devices had central foveal subfield thicknesses that were significantly more than that of TD OCT after manual correction (P<0.0001). All 3 SD OCT devices demonstrated a high degree of reproducibility in the central foveal region (ICCs, 0.92–0.97). Bland-Altman plots showed low agreeability between TD and SD OCT scans. Conclusions Out of all OCT devices analyzed, cirrus HD-OCT scans exhibited the lowest occurrence of any artifacts (68.5%), IFT (40.7%), and clinically significant IFT (11.1%), whereas Stratus OCT scans exhibited the highest occurrence of clinically significant IFT. Further work on improving segmentation algorithm to decrease artifacts is warranted.Research to Prevent Blindness, Inc. (United States) (Challenge Grant)National Institutes of Health (U.S.) (Grant R01-EY11289-23)National Institutes of Health (U.S.) (Grant R01-EY13178-07)National Institutes of Health (U.S.) (Grant P30-EY008098)United States. Air Force Office of Scientific Research (Grant FA9550-07-1-0101)United States. Air Force Office of Scientific Research (Grant FA9550-07-1-0014