4,199 research outputs found
The Origin of Radio Emission in Low-Luminosity Active Galactic Nuclei: Jets, Accretion Flows, or Both?
The low-luminosity active galactic nuclei in NGC 3147, NGC 4203, and NGC 4579
have been imaged at four frequencies with the Very Long Baseline Array. The
galaxies are unresolved at all frequencies, with size upper limits of
times the Schwarzschild radii of their central massive black holes.
The spectral indices between 1.7 and 5.0 GHz range from 0.2 to 0.4; one and
possibly two of the galaxies show spectral turnovers between 5.0 and 8.4 GHz.
The high brightness temperatures ( K) and relatively straight spectra
imply that free-free emission and/or absorption cannot account for the slightly
inverted spectra. Although the radio properties of the cores superficially
resemble predictions for advection-dominated accretion flows, the radio
luminosities are too high compared to the X-ray luminosities. We suggest that
the bulk of the radio emission is generated by a compact radio jet, which may
coexist with a low radiative efficiency accretion flow.Comment: To appear in ApJ (Letters). 4 page
Radio Emission from the Intermediate-mass Black Hole in the Globular Cluster G1
We have used the Very Large Array (VLA) to search for radio emission from the
globular cluster G1 (Mayall-II) in M31. G1 has been reported by Gebhardt et al.
to contain an intermediate-mass black hole (IMBH) with a mass of ~2 x 10^4
solar masses. Radio emission was detected within an arcsecond of the cluster
center with an 8.4 GHz power of 2 x 10^{15} W/Hz. The radio/X-ray ratio of G1
is a few hundred times higher than that expected for a high-mass X-ray binary
in the cluster center, but is consistent with the expected value for accretion
onto an IMBH with the reported mass. A pulsar wind nebula is also a possible
candidate for the radio and X-ray emission from G1; future high-sensitivity
VLBI observations might distinguish between this possibility and an IMBH. If
the radio source is an IMBH, and similar accretion and outflow processes occur
for hypothesized ~ 1000-solar-mass black holes in Milky Way globular clusters,
they are within reach of the current VLA and should be detectable easily by the
Expanded VLA when it comes on line in 2010.Comment: ApJ Letters, accepted, 11 pages, 1 figur
A Search for Active Galactic Nuclei in Sc Galaxies with H II Spectra
(Abridged) We have searched for nuclear radio emission from a statistically
complete sample of 40 Sc galaxies within 30 Mpc that are optically classified
as star-forming objects, in order to determine whether weak AGNs might be
present. Only three nuclear radio sources were detected, in NGC 864, NGC 4123,
and NGC 4535. These galaxies have peak 6-cm radio powers of 10^{20} W/Hz at
arcsecond resolution, while upper limits of the non-detected galaxies typically
range from 10^{18.4} to 10^{20} W/Hz. The three nuclear radio sources all are
resolved and appear to have diffuse morphologies, with linear sizes of ~300 pc.
This strongly indicates that circumnuclear star formation has been detected in
these three H II galaxies. Comparison with previous 20-cm VLA results for the
detected galaxies shows that the extended nuclear radio emission has a flat
spectrum in two objects, and almost certainly is generated by thermal emission
from gas ionized by young stars in the centers of those galaxies. The 6-cm
radio powers are comparable to predictions for thermal emission that are based
on the nuclear H-alpha luminosities, and imply nuclear star formation rates of
0.08-0.8 solar masses/yr, while the low-resolution NRAO VLA Sky Survey implies
galaxy-wide star formation rates of 0.3-1.0 solar masses/yr in stars above 5
solar masses. Although the presence of active nuclei powered by massive black
holes cannot be definitively ruled out, the present results suggest that they
are likely to be rare in these late-type galaxies with H II spectra.Comment: To appear in ApJ. 7 page
Novel Small Leucine-Rich Protein Chondroadherin-like (CHADL) is Expressed in Cartilage and Modulates Chondrocyte Differentiation.
The constitution and biophysical properties of extracellular matrices can dramatically influence cellular phenotype during development, homeostasis, or pathogenesis. These effects can be signaled through a differentially regulated assembly of collagen fibrils, orchestrated by a family of collagen-associated Small Leucine-Rich Proteins, SLRPs. In this report, we describe the tissue-specific expression and function of a previously uncharacterized SLRP Chondroadherin-like (CHADL). We have developed antibodies against CHADL and, by immunohistochemistry, detected CHADL expression mainly in skeletal tissues, particularly in fetal cartilage and in pericellular space of adult chondrocytes. In situ hybridizations and immunoblots on tissue lysates confirmed this tissue-specific expression pattern. Recombinant CHADL bound collagen in cell culture, and inhibited in vitro collagen fibrillogenesis. After Chadl shRNA knockdown chondrogenic ATDC5 cells increased their proliferation and differentiation, indicated by increased transcript levels of Sox9, Ihh, Col2a1, and Col10a1. The knockdown increased collagen II and aggrecan deposition in the cell layers. Microarray analysis of the knockdown samples suggested collagen receptor-related changes, although other upstream effects could not be excluded. Together, our data indicate that the novel SLRP CHADL is expressed in cartilaginous tissues, influences collagen fibrillogenesis, and modulates chondrocyte proliferation and differentiation. CHADL appears to have a negative regulatory role, possibly ensuring the formation of a stable extracellular matrix
Capecitabine as Salvage Treatment for Lymphoepithelioma-Like Carcinoma of Lung
AbstractLymphoepithelioma-like carcinoma (LELC) of lung has previously demonstrated good clinical response to 5-fluorouracil containing chemotherapy regimen, similar to the observation in undifferentiated nasopharyngeal carcinoma. Capecitabine, which is converted into active 5-fluorouracil within tumor cells, has been found effective in colorectal, breast, and recently nasopharyngeal carcinomas. We report our experience in five patients with advanced or metastatic LELC of lung who were treated with single agent capecitabine as salvage chemotherapy. The finding of disease control in three of five patients, especially with exceptionally durable stable disease (14.8 months) in one patient, suggests the potential clinical activity of capecitabine in LELC of lung. Future studies on capecitabine-containing chemotherapy regimens in LELC of lung are warranted
The Radio Quiescence of Active Galaxies with High Accretion Rates
We present 6 cm Very Large Array observations of the Greene & Ho (2004)
sample of 19 low-mass active galaxies with high accretion rates. This is one of
the only studies of a uniform sample of narrow-line Seyfert 1 (NLS1) galaxies
with such high sensitivity and resolution. Although we detect only one source,
the entire sample is very radio-quiet down to strong limits. GH10 was found to
have a radio power of 8.5 x 10^21 W/Hz, and a ratio R = f(6 cm)/f(4400 A) of
2.8. The 3 sigma upper limits for the remaining nondetections correspond to
radio powers from 3 x 10^20 to 8 x 10^21 W/Hz and 0.47 < R <9.9. Stacking all
nondetections yields an even stronger upper limit of R < 0.27. An assessment of
existing observations in the literature confirms our finding that NLS1s are
consistently radio-quiet, with a radio-loud fraction of 0%-6%, which is
significantly lower than the 10%-20% observed in the general quasar population.
By analogy with stellar-mass black holes, we argue that AGNs undergo a state
transition at L_bol/L_Edd~0.01. Below this value a radiatively inefficient
accretion flow effectively drives an outflow, which disappears when the flow
turns into an optically thick, geometrically thin disk, or a radiation
pressure-dominated slim disk at still higher L_bol/L_Edd.Comment: To appear in ApJ; 8 pages, 3 figures; uses emulateapj5.st
Tomography of X-ray Nova Muscae 1991: Evidence for ongoing mass transfer and stream-disc overflow
We present a spectroscopic analysis of the black hole binary Nova Muscae 1991
in quiescence using data obtained in 2009 with MagE on the Magellan Clay
telescope and in 2010 with IMACS on the Magellan Baade telescope at the Las
Campanas Observatory. Emission from the disc is observed in H alpha, H beta and
Ca II (8662 A). A prominent hotspot is observed in the Doppler maps of all
three emission lines. The existence of this spot establishes ongoing mass
transfer from the donor star in 2009-2010 and, given its absence in the
1993-1995 observations, demonstrates the presence of a variable hotspot in the
system. We find the radial distance to the hotspot from the black hole to be
consistent with the circularization radius. Our tomograms are suggestive of
stream-disc overflow in the system. We also detect possible Ca II (8662 A)
absorption from the donor star.Comment: 10 pages, 11 figures, 1 table. Accepted for publication in MNRA
Assessment of Artifacts and Reproducibility across Spectral- and Time-Domain Optical Coherence Tomography Devices
Purpose
To report the frequency of optical coherence tomography (OCT) scan artifacts and to compare macular thickness measurements, interscan reproducibility, and interdevice agreeability across 3 spectral-domain (SD) OCT (also known as Fourier domain; Cirrus HD-OCT, RTVue-100, and Topcon 3D-OCT 1000) devices and 1 time-domain (TD) OCT (Stratus OCT) device.
Design
Prospective, noncomparative, noninterventional case series.
Participants
Fifty-two patients seen at the New England Eye Center, Tufts Medical Center Retina Service, between February and August 2008.
Methods
Two scans were performed for each of the SD OCT protocols: Cirrus macular cube 512×128 (software version 3.0; Carl Zeiss Meditec, Inc., Dublin, CA), RTVue (E)MM5 and MM6 (software version 3.5; Optovue, Inc., Fremont, CA), Topcon 3D Macular and Radial (software version 2.12; Topcon, Inc., Paramus, NJ), in addition to 1 TD OCT scan via Stratus macular thickness protocol (software version 4.0; Carl Zeiss Meditec, Inc.). Scans were inspected for 6 types of OCT scan artifacts and were analyzed. Interscan reproducibility and interdevice agreeability were assessed by intraclass correlation coefficients (ICCs) and Bland-Altman plots, respectively.
Main Outcome Measures
Optical coherence tomography image artifacts, macular thickness, reproducibility, and agreeability.
Results
Time-domain OCT scans contained a significantly higher percentage of clinically significant improper central foveal thickness (IFT) after manual correction (11-μm change or more) compared with SD OCT scans. Cirrus HD-OCT had a significantly lower percentage of clinically significant IFT (11.1%) compared with the other SD OCT devices (Topcon 3D, 20.4%; Topcon Radial, 29.6%; RTVue (E)MM5, 42.6%; RTVue MM6, 24.1%; P = 0.001). All 3 SD OCT devices had central foveal subfield thicknesses that were significantly more than that of TD OCT after manual correction (P<0.0001). All 3 SD OCT devices demonstrated a high degree of reproducibility in the central foveal region (ICCs, 0.92–0.97). Bland-Altman plots showed low agreeability between TD and SD OCT scans.
Conclusions
Out of all OCT devices analyzed, cirrus HD-OCT scans exhibited the lowest occurrence of any artifacts (68.5%), IFT (40.7%), and clinically significant IFT (11.1%), whereas Stratus OCT scans exhibited the highest occurrence of clinically significant IFT. Further work on improving segmentation algorithm to decrease artifacts is warranted.Research to Prevent Blindness, Inc. (United States) (Challenge Grant)National Institutes of Health (U.S.) (Grant R01-EY11289-23)National Institutes of Health (U.S.) (Grant R01-EY13178-07)National Institutes of Health (U.S.) (Grant P30-EY008098)United States. Air Force Office of Scientific Research (Grant FA9550-07-1-0101)United States. Air Force Office of Scientific Research (Grant FA9550-07-1-0014
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