COVID-19 PANDEMIA AND PUBLIC AND GLOBAL MENTAL HEALTH FROM THE PERSPECTIVE OF GLOBAL HEALTH SECURITY

The Coronavirus disease 2019 (COVID-19) pandemic emerged in Wuhan, China and has spread all over the world and has caused huge threats to health and lives. It has affected different frontiers of lives and induced many psychiatric individual and collective problems such as panic, anxiety, depression, post-traumatic stress disorders, suspiciousness, infodemia, cacophony, xenophobia, racisms, etc. The COVID-19 outbreak has induced public and global mental health crisis as well as a huge psychosocial experiment. Psychiatry and other mental health sciences can play very useful role in supporting the well-being of COVID-19 patients and their families, healthcare personnel and the society. For successful fighting with present and future pandemics we have to learn more about psychiatric and psychological aspects of COVID-19 from the perspectives of public and global mental health

PERSONALITY TRAITS AND TREATMENT COMPLIANCE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS

Background: Personality traits, especially types A/B and D, have been linked to negative outcomes in various somatic illnesses. In this study, we aimed to assess the prevalence of personality types and their association with certain aspects of treatment compliance in patients with type 2 diabetes mellitus (T2DM). Subjects and methods: Participants in this study were 91 in- and outpatients suffering from T2DM and 73 healthy control subjects. All the participants filled out standardized self-report measures of personality types A/B (Bortner Rating Scale) and D (Type D Scale; DS-14). In addition, two aspects of treatment compliance were assessed: blood glucose assessment and visits to the primary care physician. Results: We found a higher incidence of personality type B (χ2=4.086, p=0.049) and personality type D (χ2=4.215, p=0.048) in the group of T2DM patients compared to healthy controls. Patients with type D personality were less compliant in terms of the visits to the primary care physician (χ2=4.229, p=0.040), although they were more prevalent among those who were compliant regarding the frequency of blood glucose assessment (χ2=4.022, p=0.045). Conclusion: The current study shows that type B and type D personality are frequent among T2DM patients. Moreover, type D personality could lead to certain aspects of suboptimal health behaviors and, therefore, interfere with disease management in diabetic populations

Razvoj aktivnih i pasivnih metoda za akviziciju značajnih vrednosti u niskonaponskim električnim mrežama

This paper presents the modern methods for determination of failure location in high voltage electrical networks with computer aided design technology. Also is performed comparison of passive and active methods for acquisition, transmission and processing of important data from electrical low voltage networks which can be used in agricultural engineering.U radu su prikazani savremeni pasivni i aktivni metodi za određivanje mesta kvara na električnim mrežama uz pomoć računarske tehnologije. Izvedena je i komparacija pasivnih i aktivnih metoda za akviziciju, prenos i obradu značajnih podataka iz niskonaponskih električnih mreža koje se koriste i u poljoprivrednoj tehnici

Uređaji sa simetričnim komponentama za smanjenje nesimetrije faznih napona u niskonaponskim električnim mrežama

In this paper here are discussed possibilities for reduction of phase voltage asymmetrical by transversally connected shunt symmetric components with reactive elements, which influence the currents of zero order and improve the symmetry of phase voltages in low voltage electrical network’s.U radu su razmotrene mogućnosti smanjenja nesimetrije faznih napona pomoću poprečno uključenih šantiranih simetričnih komponenti sa reaktivnim elementima čime se ustvari deluje na struje nultog redosleda i poboljšava simetrija faznih napona u niskonaponskim električnim mrežama

Uticaj primene vodenih ekstrakata na prinos u organskoj proizvodnji soje

Biennial soya research was done in the surroundings of Bačka Topola. The field experiment was set by a replicate randomised complete block design. The goal was to determine the influence of aqueous plant extracts on soybean grain yield in an organic breeding system. A variance analasys was done and the central values between applied treatments were tested by a test of least significant differences. The applied treatment revealed a very significant influence. There were statistically significant differences between all variants. The yield was highest whilst a foliar application of a fermented nettle and common comfrey combination, which was performed in three repetitions that had time gaps of two weeks in between.Dvogodišnja istraživanja sa sojom, sprovedena su u okolini Bačke Topole. Poljski eksperimentalni ogled bio je postavljen po dizajnu slučajnog blok sistema. Cilj je bio da se utvrdi uticaj vodenih biljnih ekstarkata na prinos zrna soje u organskom sistemu gajenja. Urađena je analiza varijanse, a srednje vrednosti između primenjenih tretmana testirane su testom najmanje značajnih razlika. Primenjeni tretman ispoljio je statistički vrlo značajan uticaj. Između svih varijanti postojale su statistički zanačajne razlike. Najviši prinos ostvaren je kod folijarno primenjene kombinacija fermentisane korive i gaveza u tri navrata sa po dve nedelje razmaka između primena

ASSOCIATIONS OF GENE VARIATIONS IN NEUROPEPTIDE Y AND BRAIN DERIVED NEUROTROPHIC FACTOR GENES WITH POSTTRAUMATIC STRESS DISORDER

Background: Individuals who are exposed to traumatic events are at an increased risk of developing posttraumatic stress disorder (PTSD), a condition during which an individual\u27s ability to function is impaired by emotional responses to memories of those events. The gene coding for neuropeptide Y (NPY) and the gene coding for brain-derived neurotrophic factor (BDNF) are among the number of candidate gene variants that have been identified as potential contributors to PTSD. The aim of this study was to investigate the association between NPY and BDNF and PTSD in individuals who experienced war-related trauma in the South Eastern Europe (SEE) conflicts (1991-1999). Subjects and methods: This study included participants with current and remitted PTSD and healthy volunteers (N=719, 232 females, 487 males), who were recruited between 2013 and 2015 within the framework of the South Eastern Europe (SEE) - PTSD Study. Psychometric methods comprised the Mini International Neuropsychiatric Interview (M.I.N.I.), the Clinician Administered PTSD Scale (CAPS), and the Brief Symptom Inventory (BSI). DNA was isolated from whole blood and genotyped for NPY rs5574 via PCR - RFLP and NPY rs16147 and BDNF rs6265 using the KASP assay. Results: Tests for deviation from Hardy-Weinberg equilibrium showed no significant results. Analyses at the categorical level yielded no associations between the affected individuals and all three SNPs when compared to controls. Within lifetime PTSD patients, the major alleles of both NPY variants showed a nominally significant association with higher CAPS scores (p=0.007 and p=0.02, respectively). Also, the major allele of rs5574C>T was associated with higher BSI scores with a nominal significance among current PTSD patients (p=0.047). The results did not withstand a Bonferroni adjustment (????=0.002). Conclusion: Nominally significant associations between NPY polymorphisms and PTSD susceptibility were found that did not withstand Bonferroni correction

ASSOCIATIONS BETWEEN POLYMORPHISMS IN THE SOLUTE CARRIER FAMILY 6 MEMBER 3 AND THE MYELIN BASIC PROTEIN GENE AND POSTTRAUMATIC STRESS DISORDER

Background: Previous research showed inconsistent results concerning a possible association between solute carrier family 6 member 3 (SLC6A3) gene polymorphisms and dopamine symptoms of posttraumatic stress disorder (PTSD). Several studies also indicate that the myelin basic protein (MBP) gene is of importance in the etiology of several psychiatric disorders. The aim of this study was to investigate the relation of distinct SLC6A3 and MBP gene polymorphisms with PTSD and whether SLC6A3 and MBP genotypes contribute to PTSD symptom severity. Subjects and methods: The study included 719 individuals who had experienced war trauma in the South Eastern Europe (SEE). Genotypes of variable number tandem repeat (VNTR) polymorphism within the SLC6A3 gene were assessed in 696 participants, and the single nucleotide polymorphism (SNP) rs12458282 located within the MBP gene region was genotyped in a total of 703 subjects. The Mini International Neuropsychiatric Interview, the Clinical Administrated PTSD Scale (CAPS) and Brief Symptom Inventory (BSI), were used for data collection. Results: No significant differences concerning the investigated SLC6A3 and MBP polymorphisms was identifiable between PTSD and non PTSD participants. Also we could not detect significant influence of these distinct SLC6A3 and MBP alleles on the severity of PTSD symptoms (CAPS) or BSI scores. However, the results of MBP rs12458282 within the patients with lifetime PTSD may point to a possible correlation of the major allele (T) with elevated CAPS scores. Conclusions: Our results do not support an association of the analysed SLC6A3 and MBP gene polymorphisms with PTSD in war traumatized individuals. We found that there is a possibility for a correlation of the T allele rs12458282 within the MBP gene with higher CAPS scores in lifetime PTSD patients which would need to be tested in a sample providing more statistical power

ROLE OF THE ALLELIC VARIATION IN THE 5-HYDROXYTRYPTAMINE RECEPTOR 1A (HTR1A) AND THE TRYPTOPHAN HYDROXYLASE 2 (TPH2) GENES IN THE DEVELOPMENT OF PTSD

Background: Post-traumatic stress disorder (PTSD) is a stress related disorder which can occur in an individual after exposure to a traumatic event. It most commonly co-occurs with depression. The two disorders share not only overlapping symptoms, but also genetic diathesis. The aim of this study was to investigate the potential role of single nucleotide polymorphisms (SNPs) of the two serotonergic candidate genes 5-hydroxytryptamine receptor 1A (HTR1A) and tryptophan hydroxylase 2 (TPH2) in the pathogenesis of PTSD and comorbid psychopathology. Subjects and methods: 719 (487 males, 232 females) participants who had experienced war-related trauma between 1991 and 1999 in Bosnia and Herzegovina, Kosovo and Croatia were included in the study. The Sociodemographic questionnaire, Mini International Neuropsychiatric Interview (M.I.N.I.), Clinician Administered PTSD Scale (CAPS) and Brief Symptom Inventory (BSI) were used to collect clinical data. The SNPs rs6295 (HTR1A), rs11178997 and rs1386494 (TPH2) were investigated for their association with PTSD and comorbid psychopathology. Results: A nominal significant association was found between the BSI total score in Lifetime PTSD with the SNP rs6295 of the HTR1A gene. The best result was seen in the dominant model (P=0.018), with the minor allele (C) being the risk allele. Several BSI subscores were also associated with the minor (C) allele in Lifetime PTSD. No association was found for the TPH2 SNPs rs11178997 and rs1386494 in relation to PTSD or comorbid psychopathology. Conclusions: Our findings suggest that rs6295 in the HTR1A gene may contribute to the psychopathology of PTSD