Leukotrienes provide an NFAT-dependent signal that synergizes with IL-33 to activate ILC2s.

Group 2 innate lymphoid cells (ILC2s) and type 2 helper T cells (Th2 cells) are the primary source of interleukin 5 (IL-5) and IL-13 during type 2 (allergic) inflammation in the lung. In Th2 cells, T cell receptor (TCR) signaling activates the transcription factors nuclear factor of activated T cells (NFAT), nuclear factor κB (NF-κB), and activator protein 1 (AP-1) to induce type 2 cytokines. ILC2s lack a TCR and respond instead to locally produced cytokines such as IL-33. Although IL-33 induces AP-1 and NF-κB, NFAT signaling has not been described in ILC2s. In this study, we report a nonredundant NFAT-dependent role for lipid-derived leukotrienes (LTs) in the activation of lung ILC2s. Using cytokine reporter and LT-deficient mice, we find that complete disruption of LT signaling markedly diminishes ILC2 activation and downstream responses during type 2 inflammation. Type 2 responses are equivalently attenuated in IL-33- and LT-deficient mice, and optimal ILC2 activation reflects potent synergy between these pathways. These findings expand our understanding of ILC2 regulation and may have important implications for the treatment of airways disease

Inertial amplification of continuous structures: Large band gaps from small masses

Wave motion in a continuous elastic rod with a periodically attached inertial-amplification mechanism is investigated. The mechanism has properties similar to an "inerter" typically used in vehicle suspensions, however here it is constructed and utilized in a manner that alters the intrinsic properties of a continuous structure. The elastodynamic band structure of the hybrid rod-mechanism structure yields band gaps that are exceedingly wide and deep when compared to what can be obtained using standard local resonators, while still being low in frequency. With this concept, a large band gap may be realized with as much as twenty times less added mass compared to what is needed in a standard local resonator configuration. The emerging inertially enhanced continuous structure also exhibits unique qualitative features in its dispersion curves. These include the existence of a characteristic double-peak in the attenuation constant profile within gaps and the possibility of coalescence of two neighbouring gaps creating a large contiguous gap.Comment: Manuscript is under review for journal publicatio

Effect of Aqueous Ozone on the NF-κB System

Ozone has been proposed as an alternative oral antiseptic in dentistry, due to its antimicrobial power reported for gaseous and aqueous forms, the latter showing a high biocompatibility with mammalian cells. New therapeutic strategies for the treatment of periodontal disease and apical periodontitis should consider not only antibacterial effects, but also their influence on the host immune response. Therefore, our aim was to investigate the effect of aqueous ozone on the NF-κB system, a paradigm for inflammationassociated signaling/transcription. We showed that NF-κB activity in oral cells stimulated with TNF, and in periodontal ligament tissue from root surfaces of periodontally damaged teeth, was inhibited following incubation with ozonized medium. Under this treatment, IκBalpah proteolysis, cytokine expression, and κB-dependent transcription were prevented. Specific ozonized amino acids were shown to represent major inhibitory components of ozonized medium. In summary, our study establishes a condition under which aqueous ozone exerts inhibitory effects on the NF-κB system, suggesting that it has an antiinflammatory capacity

Energy and Vorticity in Fast Rotating Bose-Einstein Condensates

We study a rapidly rotating Bose-Einstein condensate confined to a finite trap in the framework of two-dimensional Gross-Pitaevskii theory in the strong coupling (Thomas-Fermi) limit. Denoting the coupling parameter by 1/\eps^2 and the rotational velocity by $\Omega$, we evaluate exactly the next to leading order contribution to the ground state energy in the parameter regime |\log\eps|\ll \Omega\ll 1/(\eps^2|\log\eps|) with \eps\to 0. While the TF energy includes only the contribution of the centrifugal forces the next order corresponds to a lattice of vortices whose density is proportional to the rotational velocity.Comment: 19 pages, LaTeX; typos corrected, clarifying remarks added, some rearrangements in the tex

Does continuous renal replacement therapy favourably influence the outcome of the patients?

Continuous haemodialysis and continuous haemofiltration are efficient and safe techniques for the treatment of acute renal failure. Theoretical advantages are improved haemodynamic stability and easier fluid removal. All 15 available studies comparing intermittent (522 patients) with continuous (651 patients) renal replacement therapy have been reviewed. From these studies it cannot be established, whether the use of a continuous instead of an intermittent treatment modality improves the outcome in patients with acute renal failure. Reviewing all 67 published studies dealing with continuous renal replacement therapy revealed a trend to a decreasing mortality rate (P<0.08) over the last 11 years, whereas the mean age and the severity of illness of the patients, measured by the APACHE II score, did not change. In order to establish whether the quality of treatment has improved as a function of time, two quality factors (QF) were created, i.e. QF for age (mean age/mean mortality rate of the patients treated) and QF for severity of diseases (mean APACHE II/mean mortality rate). Both QF improved from 1984 until 1994, when analyzed for continuous (P<0.001) or intermittent (P<0.001) treatment modality. Thus the quality of treatment of patients with acute renal failure improved during the last decade. However, there is no evidence with respect to survival rate that a continuous renal replacement therapy is superior to an intermittent on

Long-run commodity prices, economic growth and interest rates: 17th century to the present day

A significant proportion of the trade basket of many developing countries is comprised of primary commodities. This implies relative price movements in commodities may have important consequences for economic growth and poverty reduction. Taking a long-run perspective, we examine the historical relation between a new aggregate index of commodity prices, economic activity and interest rates. Initial empirical tests show that commodity prices present a downward trend with breaks over the entire industrial age, providing clear support for the Prebisch-Singer hypothesis. It would also appear that this trend has declined at a faster rate since the 1870s. Conversely, several GDP series such as World, Chile, China, UK and US, trend upwards with breaks. Such trending behaviour in both commodity prices and economic activity suggests a latent common factor like technological innovation. To assess the relationships between economic series, we apply a stationary VAR (Vector Autoregression) to model movements around trends. Strikingly, there is evidence that commodity prices Granger cause income and interest rates, whilst interest rates Granger cause commodity prices. From these results and the related impulse response function analysis, the historical perspective provides some useful information for contemporary policy makers. For example, loose monetary policy has tended to support higher commodity prices. More-over, commodity price movements have an asymmetric country effect on economic activity; periods of falling commodity prices will support GDP growth for com-modity importers like the US but depress growth for commodity exporters such as Chile

Justification of c-Number Substitutions in Bosonic Hamiltonians

The validity of substituting a c-number $z$ for the $k=0$ mode operator $a_0$ is established rigorously in full generality, thereby verifying one aspect of Bogoliubov's 1947 theory. This substitution not only yields the correct value of thermodynamic quantities like the pressure or ground state energy, but also the value of $|z|^2$ that maximizes the partition function equals the true amount of condensation in the presence of a gauge-symmetry breaking term -- a point that had previously been elusive.Comment: RevTeX4, 4pages; minor modifications in the text; final version, to appear in Phys. Rev. Let