IMPACT OF COVID-19 AND ONLINE EDUCATION ON THE MENTAL HEALTH OF MEMBERS OF EDUCATIONAL SPHERE-A CASE STUDY

Coronavirus disease 2019(COVID-19), the enormously transmissible disease resulting due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as the causative agent, instigated a dreadful outcome ensuing worldwide emergency with its rapid spread and greater mortality rate resulting in grievous disruptions. It arose as the greatest substantial world-wide health catastrophe ever since the period of influenza pandemic of 1918, causing more than 3.7 million deaths worldwide. The influence of this pandemic was ascertained in every arena of life on a worldwide level. COVID-19 has devastated many countries, thrashing our health care system besides having a major impact on the academic sector encompassing an enormous number of students, teachers along with staff members. With the implementation of the lock-down the offline classes were substituted for the online mode not only in India but globally. This has chiefly prompted an effect on the mental health of people apart from their physical health. Mental well-being has a vital significance and the spread of pandemic has accelerated a series of mental disorders ranging from anxiety, stress to depressive disorders. This review, based on questionnaires prepared using the perceived stress scale method compiles the response data of how COVID-19 has affected the mental health of students and members of the educational sphere. Not only this but it shows a contrast between the offline and the new tech-friendly online classes. Thus, this survey study reflects on creating a framework for the academic sector to aid in resolving and helping people manifested with mental health issues so as to lead a normal healthy lifestyle

Intelligent or Smart Polymers: Advance in Novel Drug Delivery

Novel drug delivery system utilizing smart polymer to get significant and attracting changes in the targeting of drugs, increasing the bioavailability of drugs, enhancement patient compliance  and gene therapy. The scientific community tries to mimic nature in the way that living organisms adopt their behavior as a function of environmental conditions to improve survival. In this sense, smart polymers offer materials that respond to numerous stimuli (temperature, pH, electric and magnetic fields, light intensity, biological molecules, etc.), and scientists must devise the best way to apply them in all research areas. Smart polymers are representing promising means for targeted drug delivery, enhanced drug delivery, gene therapy, actuator stimuli and protein folders. Smart polymers are very promising applicants in drug delivery, tissue engineering, cell culture, gene carriers, textile engineering, oil recovery, radioactive wastage and protein purification. The study is focused on the entire features of smart polymers and their most recent and relevant applications. Keywords: Smart polymer, Novel drug delivery system, Stimuli, Gene therap

Pathways of Targeted Therapy for Colorectal Cancer

One of the most common and deadly cancers in the world, colorectal cancer (CRC) caused around 881,000 melanoma deaths in 2018. The third most frequent cause overall cancer-related death worldwide is colorectal cancer (CRC). A difficult issue related to chemotherapy is the subsequent adverse effects brought on by the toxicity of conventional medications. Location-specific/targeted distribution of chemotherapeutic medicines precisely to the afflicted site of something like the colon in a foreseeable and reliable way is obviously of concern. For many years, cancer sufferers' initial choices have been surgery and chemotherapy. The prognosis for CRC, particularly for those with metastatic tumours, has never been satisfactory. A recent optional strategy called targeted therapy has been effective in extending patients with CRC's overall survival. Following achievements with the anti-EGFR (epidermal growth factor receptor) agent cetuximab and the anti-angiogenesis agent bevacizumab, new drugs that inhibit several important pathways and immune checkpoints are being developed at an unheard-of rate. The growing number of high-quality clinical trials is being used as a basis for updating guidelines worldwide regarding the recommended targeted medications. An overview of current CRC-targeted drugs and their underlying processes is given in this review, along with a discussion of their drawbacks and potential directions. Keywords: Colorectal cancer, Chemotherapeutic medicines, Bevacizumab, Cetuximab

Disruptions, restorations and adaptations to health and nutrition service delivery in multiple states across India over the course of the COVID-19 pandemic in 2020: An observational study.

BackgroundModeling studies estimated severe impacts of potential service delivery disruptions due to COVID-19 pandemic on maternal and child nutrition outcomes. Although anecdotal evidence exists on disruptions, little is known about the actual state of service delivery at scale. We studied disruptions and restorations, challenges and adaptations in health and nutrition service delivery by frontline workers (FLWs) in India during COVID-19 in 2020.MethodsWe conducted phone surveys with 5500 FLWs (among them 3118 Anganwadi Workers) in seven states between August-October 2020, asking about service delivery during April 2020 (T1) and in August-October (T2), and analyzed changes between T1 and T2. We also analyzed health systems administrative data from 704 districts on disruptions and restoration of services between pre-pandemic (December 2019, T0), T1 and T2.ResultsIn April 2020 (T1), village centers, fixed day events, child growth monitoring, and immunization were provided by ConclusionsServices to mothers and children were disrupted during stringent lockdown but restored thereafter, albeit not to pre-pandemic levels. Rapid policy guidance and adaptations by FLWs enabled restoration but little remains known about uptake by client populations. As COVID-19 continues to surge in India, focused attention to ensuring essential services is critical to mitigate these major indirect impacts of the pandemic

Abstracts of Scientifica 2022

This book contains the abstracts of the papers presented at Scientifica 2022, Organized by the Sancheti Institute College of Physiotherapy, Pune, Maharashtra, India, held on 12–13 March 2022. This conference helps bring researchers together across the globe on one platform to help benefit the young researchers. There were six invited talks from different fields of Physiotherapy and seven panel discussions including over thirty speakers across the globe which made the conference interesting due to the diversity of topics covered during the conference. Conference Title:  Scientifica 2022Conference Date: 12–13 March 2022Conference Location: Sancheti Institute College of PhysiotherapyConference Organizer: Sancheti Institute College of Physiotherapy, Pune, Maharashtra, Indi