Formulation and Evaluation of Extended Release Floating Matrix Tablet of Eperisone Hydrochloride by Direct Compression Method

Increased complications and costs of marketing of innovative drugs focused greater attention to the development of sustained release (SR) or controlled release (CR) drug delivery systems. Delivery systems extended release or controlled release rate can achieve predictable and reproducible, the extended duration of activity for the short time of life - drugs, reduced toxicity and dose reduction request, the optimized therapy and better patient compliance. It is controlled primarily by the type and the proportion of the polymers used in the preparation. Eperisone hydrochloride is a centrally acting muscle relaxant acting through poly and mono-synaptic reflexes in the spinal cord, exhibits vasodilator effect, increases blood flow and inhibits the pain reflex pathway. The objective of present work was to develop and evaluated oral extended release floating matrix tablet of eperisone HCl prepared by the method of direct compression, using hydroxy propyl methyl cellulose (HPMC K15, HPMC K4) and PVP K30 as matrix formation polymers. Sodium bicarbonate and citric acid was used as gas generating agents. The FTIR spectra of the eperisone HCl and other excipients alone and in combination show the compatibility of the drug and excipients. Nine formulations of different polymer percentages were formulated (F1-F9). Pre-compression parameters were evaluated. The influence of matrix forming agents and binary mixtures of them on eperisone HCl release was investigated. The formulated tablets were characterized by thickness and diameter, drug content, hardness, friability, uniformity of weight, In vitro buoyancy studies and dissolution rate studies. The formulated tablets had acceptable physicochemical characters. The data obtained from the in-vitro dissolution studies of optimized batch F7 were fitted in different models. The optimized formulation F7 showed 99.45±0.45% drug content and floating lag times of 65±4 sec. Drug release mechanism was found to be first order kinetics. Eperisone HCl floating tablets exhibited increased gastric residence time, there by improved bioavailability and therapeutic effect of the drug. Keywords: Sustained release, Eperisone hydrochloride, Direct compression, Pre and post compression parameter

Formulation and Evaluation of Sustained Release Matrix Tablets of Isoxsuprine Hydrochloride by Direct Compression Method

A sustained-release tablet formulation should ideally have a proper release profile insensitive to moderate changes in tablet hardness that is usually encountered in manufacturing. Isoxsuprine hydrochloride is structurally a novel vasodilator. The short biological half-life (5±2 hr) and the fast clearance make the drug, a suitable candidate for the development of modified release formulation. A novel oral controlled delivery system for isoxsuprine hydrochloride was developed and optimized. Matrix tablets of isoxsuprine hydrochloride were prepared by using hydroxypropylmethylcellulose (HPMC K15), Gaur Gum and PVP K 30 as polymer substance to achieve required sustained release profile. The matrix tablets were prepared by direct compression method which is now days considered a cost effective and simple method of manufacturing. It is considered as an appropriate method for hygroscopic and thermolabile substances. Six formulations of different polymer percentages were formulated (F1-F6). Pre-compression parameters were evaluated. The influence of matrix forming agents and binary mixtures of them on isoxsuprine hydrochloride release was investigated. The formulated tablets were characterized by hardness, friability, thickness, weight variation and in vitro drug release. The formulated tablets had acceptable physicochemical characters. There was no chemical interaction found between the drug and excipients throughout FT-IR and UV study thought of in the present investigation. The quantity of isoxsuprine hydrochloride present in the tablets and the release medium were estimated by a simple, rapid and validated UV method. The dissolution results show that increased amount of polymer resulted in reduced and extended drug release. F4 formulation is the optimum formulation due to its better targeting profile in terms of release. First order kinetic profiles were achieved. This formulation may provide an alternative for oral controlled delivery of isoxsuprine hydrochloride and be helpful in the future treatment of   peripheral vascular disease. Keywords: Isoxsuprine hydrochloride, HPMC K15, Gaur Gum, PVP K30, Direct compression method, Dissolutio

Coplanar Wave Guide Fed Dual Band Notched MIMO Antenna

A coplanar wave guide fed of semicircle monopole antenna is designed in this work to overcome polarization diversity mimo technique is implemented in this paper. The proposed antenna is designed to notch a particular band of frequencies in UWB range. The designed model is notching the first band from 2 to 5 GHz & the second band from 7 to 11 GHz. The proposed antenna has been fabricated on FR4 substrate with di electric constant 4.4 & tested for its reliability on ZNB20 vector network analyzer. The operating bands will come under WLAN, KU band, satellite communication applications. A peak realized gain of 4.3 dB with radiation efficiency 90% is attained at the operating bands of the designed antenna. At notch band significant gain reduction is observed from the current design. The antenna is showing omnidirectional radiation pattern in the pass band & disturbed radiation pattern in the notch band. Antenna is fabricated with dimensions of 40x68x1.6 mm & simulation works are carried with finite element method based HFSS tool