Existential Foundherentism of Mulla Sadra in the Justification Element

The truth of knowledge was considered by western philosophers and epistemologists long time ago unclear sentence. They were mostly foundationalists or coherentists in the justification element. Muslim philosophers specifically paid attention to the problem of knowledge, and defined it as constant certainty corresponding reality. In consideration of ternary definition of knowledge, it can be deduced that Muslim philosophers accepted the corresponding theory in truth element, and accepted foundationalism in justification element. Though, epistemological model of Sadra is different from those of Muslim philosophers in consideration of different evaluations of statements, and emphasis on different role and place of proof and mystic intuition in reaching knowledge, and on the other hand, by accepting that knowledge is existential, and by reducing conceptual knowledge to immediate knowledge. Understanding of Mulla Sadra's theory requires examining his method of the justification element. Various aspects are indicated to distinguish between the Transcendent Philosophy and other philosophical schools. In this view, mystic intuition can play a justifying role. From viewpoint of Mulla Sadra, what should be followed are proof and mystic intuition. In the Sadra’s system, revelation is the criterion for evaluation of mystic intuition. So, reaching knowledge demands the existence of proof or mystic intuition, and the truth of the latter should be evaluated by the revelation. Epistemic system of Sadra is formed by three elements of proof, mystic intuition, and revelation being interrelated to each other. Explaining the epistemological role of proof, mystic intuition, and revelation addresses the context of justification, uncovering the theory of the Transcendent Philosophy about the knowledge. Methods  This study describes the problems, analyzes them, and in some cases, criticizes them using a literature review. Results and discussion After determination of the ternary epistemic elements, viz. proof, mystic intuition, and revelation, it can be concluded that real knowledge is gained through proof or mystic intuition. In an initial look, it seems that proof and mystic intuition are different, but since he believes that real knowledge is the immediate knowledge, it can be believed that proof and mystic intuition are single and the same, and that the reality of both is the existential encountering with non-material reality. Each of proof and mystic intuition is preparing a cause for encountering non-material existence and gaining knowledge. After considering the theories that set forth the justifying element in the Sadra’s system, and examining their faults according to this system, another theory is reached herein about justifying element, which is not just foundationalism or coherentism. Conclusion In our opinion, in consideration of epistemological foundations of the Transcendent Philosophy, one cannot believe that Mulla Sadra's theory of justification is the same as those of other Muslim epistemologists. Mulla Sadra's theory of justification is a compound one that authors named it as “existential foundherentism”. From the viewpoint of Mulla Sadra, proof and mystic intuition (purification of the soul) are the preparing causes for the existential encountering of non-material existence, and consequently, for justifying the beliefs. Coherentism of Mulla Sadra and his reliance on proof is the realm of conceptual knowledge. This means that in the realm of conceptual knowledge, he believes in two kinds of statements, i.e. foundational and non-foundational, and justifies the latter by the former. Mulla Sadra's cohrtentism implies his belief of conceptual knowledge to be compatible with immediate knowledge, the latter being compatible to the former. In consideration of Mulla Sadra's foundation, the reality of proof and mystic intuition is unique and the same, and that reality is immediate encountering the object of knowledge. This encountering, as a result, is a product of proof or purification of the soul, that is, both promote the existence of the knower and put him/her in the presence of object of the knowledge, and just here, object of the knowledge attends for the knower and the identity of knower and known occurs. The compound theory named “existential foundherentism”, pays attention both to the role of proof and the mystic intuition. Although in some of his works, Mulla Sadra only emphasizes the proof for justifying the statements, his final viewpoint is to follow proof or mystic intuition, and that proof proves, hence it cannot be incompatible with the mystic intuition, and real proof is not against to the mystic intuition

Data on prevalence of additive colors in local food and beverage products, Tehran, Iran

The quality check and determination of permitted and non-permitted additive colors in food products is very important for customer׳s right protection and health. This survey was undertaken to demonstrate the frequently use of additive colors and products targeted to color adulteration in Iranian foods and beverages. From the 1120 of the samples, 18.86% contained artificial colors, 11.89% contained natural colors and 69.25% of samples had no additive colors. Tartrazine (E102) was the only non-permitted artificial dye used in samples. Among products with additive colors, only 4.38% of samples failed to meet with national Iranian standard and 61.23% of non-compliance samples were from non-industrial sectors and mostly were saffron and food containing saffron such as saffron rock candy and saffron chicken. These places and products quality are main the concern to solve the color adulteration in Iranian food market. Keywords: Artificial additive colors, Natural additives colors, Permitted colors, Non-permitted color

Traumatic brain injury alters neuropsychiatric symptomatology in all-cause dementia.

INTRODUCTION: Traumatic brain injury (TBI) may alter the course of neuropsychiatric symptom (NPS) onset during dementia development. The connection among TBI, NPS, and dementia progression is of increasing interest to researchers and clinicians. METHODS: Incidence of NPS was examined in participants with normal cognition who progressed to all-cause dementia based on whether TBI history was present (n = 130) or absent (n = 849). Survival analyses were used to examine NPS incidence across 7.6 ± 3.0 years of follow-up. RESULTS: Participants with TBI history had increased prevalence and incidence of apathy (44.7% vs 29.9%, P = .0062; HR DISCUSSION: History of TBI is associated with increased risk for and earlier onset of NPS in the trajectory of dementia development

History of traumatic brain injury interferes with accurate diagnosis of Alzheimer\u27s dementia: a nation-wide case-control study.

Traumatic brain injury (TBI) and Alzheimer\u27s disease (AD) bear a complex relationship, potentially increasing risk of one another reciprocally. However, recent evidence suggests post-TBI dementia exists as a distinct neurodegenerative syndrome, confounding AD diagnostic accuracy in clinical settings. This investigation sought to evaluate TBI\u27s impact on the accuracy of clinician-diagnosed AD using gold standard neuropathological criteria. In this preliminary analysis, data were acquired from the National Alzheimer\u27s Coordinating Centre (NACC), which aggregates clinical and neuropathologic information from Alzheimer\u27s disease centres across the United States. Modified National Institute on Aging-Reagan criteria were applied to confirm AD by neuropathology. Among participants with clinician-diagnosed AD, TBI history was associated with misdiagnosis (false positives) (OR = 1.351 [95% CI: 1.091-1.674]

Effect of Weight Class on Regional Brain Volume, Cognition, and Other Neuropsychiatric Outcomes among Professional Fighters.

Traumatic brain injury (TBI) is a common source of functional impairment among athletes, military personnel, and the general population. Professional fighters in both boxing and mixed martial arts (MMA) are at particular risk for repetitive TBI and may provide valuable insight into both the pathophysiology of TBI and its consequences. Currently, effects of fighter weight class on brain volumetrics (regional and total) and functional outcomes are unknown. Fifty-three boxers and 103 MMA fighters participating in the Professional Fighters Brain Health Study (PRBHS) underwent volumetric magnetic resonance imaging (MRI) and neuropsychological testing. Fighters were divided into lightweight (≤139.9 lb), middleweight (140.0-178.5 lb), and heavyweight (\u3e178.5 lb). Compared with lightweight fighters, heavyweights displayed greater yearly reductions in regional brain volume (boxers: bilateral thalami; MMA: left thalamus, right putamen) and functional performance (boxers: processing speed, simple and choice reaction; MMA: Trails A and B tests). Lightweights suffered greater reductions in regional brain volume on a per-fight basis (boxers: left thalamus; MMA: right putamen). Heavyweight fighters bore greater yearly burden of regional brain volume and functional decrements, possibly related to differing fight dynamics and force of strikes in this division. Lightweights demonstrated greater volumetric decrements on a per-fight basis. Although more research is needed, greater per-fight decrements in lightweights may be related to practices of weight-cutting, which may increase vulnerability to neurodegeneration post-TBI. Observed decrements associated with weight class may result in progressive impairments in fighter performance, suggesting interventions mitigating the burden of TBI in professional fighters may both improve brain health and increase professional longevity

Effect of traumatic brain injury on mild behavioral impairment domains prior to all‐cause dementia diagnosis and throughout disease progression

Abstract Introduction Traumatic brain injury (TBI) may alter dementia progression, although co‐occurring neuropsychiatric symptoms (NPS) have received less attention. Originally designed to evaluate behavioral disruption prior to dementia diagnosis, the mild behavioral impairment (MBI) construct relates NPS to underlying neural circuit disruptions, with probable relevance across the progression of neurodegenerative disease. Therefore, the MBI construct may represent a valuable tool to identify and evaluate related NPS both preceding diagnosis of all‐cause dementia throughout the progression of disease, representing an important area of inquiry regarding TBI and dementia. This investigation sought to evaluate the effect of TBI on NPS related by the MBI construct in participants progressing from normal cognitive status to all‐cause dementia. Methods Using National Alzheimer's Coordinating Center data, individuals progressing from normal cognition to all‐cause dementia (clinician diagnosed) over 7.6 ± 3.0 years were studied to estimate prevalence of MBI domains in 124 participants with prior TBI history (57 with loss of consciousness [LOC] 5 min, 45 unknown severity) compared to 822 without. MBI domain prevalence was evaluated (1) prior to dementia onset (including only time points preceding time at dementia diagnosis, as per MBI's original definition) and (2) throughout dementia progression (evaluating all available time points, including both before and after dementia diagnosis). Results More severe TBI (LOC >5 minutes) was associated with the social inappropriateness MBI domain (adjusted odds ratio = 4.034; P = 0.024) prior to dementia onset, and the abnormal perception/thought content domain looking across dementia progression (adjusted hazard ratio [HRadj] = 3.703; P = 0.005). TBI (all severities) was associated with the decreased motivation domain looking throughout dementia progression (HRadj. = 1.546; P = 0.014). Discussion TBI history is associated with particular MBI profiles prior to onset and throughout progression of dementia. Understanding TBI's impact on inter‐related NPS may help elucidate underlying neuropathology with implications for surveillance, detection, and treatment of behavioral concerns in aging TBI survivors. Highlights The mild behavioral impairment (MBI) construct links related neuropsychiatric symptoms (NPS) by probable underlying neural network dysfunction. Traumatic brain injury (TBI) with loss of consciousness (LOC) > 5 minutes was associated with pre‐dementia social inappropriateness. TBI was associated with decreased motivation looking across dementia progression. TBI with LOC > 5 minutes was associated with abnormal perception/thought content. The MBI construct may be useful for examining related NPS across dementia progression

Neuroimaging Correlates of Syndromal Anxiety Following Traumatic Brain Injury: A Systematic Review of the Literature.

BACKGROUND: Traumatic brain injury (TBI) can precipitate new-onset psychiatric symptoms or worsen existing psychiatric conditions. To elucidate specific mechanisms for this interaction, neuroimaging is often used to study both psychiatric conditions and TBI. This systematic review aims to synthesize the existing literature of neuroimaging findings among patients with anxiety after TBI. METHODS: We conducted a Preferred Reporting Items for Systematic Review and Meta-Analyses-compliant literature search via PubMed (MEDLINE), PsychINFO, EMBASE, and Scopus databases before May, 2019. We included studies that clearly defined TBI, measured syndromal anxiety as a primary outcome, and statistically analyzed the relationship between neuroimaging findings and anxiety symptoms. RESULTS: A total of 5982 articles were retrieved from the systematic search, of which 65 studied anxiety and 13 met eligibility criteria. These studies were published between 2004 and 2017, collectively analyzing 764 participants comprised of 470 patients with TBI and 294 non-TBI controls. Imaging modalities used included magnetic resonance imaging, functional magnetic resonance imaging, diffusion tensor imaging, electroencephalogram, magnetic resonance spectrometry, and magnetoencephalography. Eight of 13 studies presented at least one significant finding and together reflect a complex set of changes that lead to anxiety in the setting of TBI. The left cingulate gyrus in particular was found to be significant in 2 studies using different imaging modalities. Two studies also revealed perturbances in functional connectivity within the default mode network. CONCLUSIONS: This is the first systemic review of neuroimaging changes associated with anxiety after TBI, which implicated multiple brain structures and circuits, such as the default mode network. Future research with consistent, rigorous measurements of TBI and syndromal anxiety, as well as attention to control groups, previous TBIs, and time interval between TBI and neuroimaging, are warranted. By understanding neuroimaging correlates of psychiatric symptoms, this work could inform future post-TBI screening and surveillance, preventative efforts, and early interventions to improve neuropsychiatric outcomes

Behavioral and Emotional Dyscontrol Following Traumatic Brain Injury: A Systematic Review of Neuroimaging and Electrophysiological Correlates.

BACKGROUND: Behavioral and emotional dyscontrol commonly occur following traumatic brain injury (TBI). Neuroimaging and electrophysiological correlates of dyscontrol have not been systematically summarized in the literature to date. OBJECTIVE: To complete a systematic review of the literature examining neuroimaging and electrophysiological findings related to behavioral and emotional dyscontrol due to TBI. METHODS: A Preferred Reporting Items for Systematic Reviews and Meta-Analyses-compliant literature search was conducted in PubMed (MEDLINE), PsycINFO, EMBASE, and Scopus databases prior to May 2019. The database query yielded 4392 unique articles. These articles were narrowed based on specific inclusion criteria (e.g., clear TBI definition, statistical analysis of the relationship between neuroimaging and dyscontrol). RESULTS: A final cohort of 24 articles resulted, comprising findings from 1552 patients with TBI. Studies included civilian (n = 12), military (n = 10), and sport (n = 2) samples with significant variation in the severity of TBI incorporated. Global and region-based structural imaging was more frequently used to study dyscontrol than functional imaging or diffusion tensor imaging. The prefrontal cortex was the most common neuroanatomical region associated with behavioral and emotional dyscontrol, followed by other frontal and temporal lobe findings. CONCLUSIONS: Frontal and temporal lesions are most strongly implicated in the development of postinjury dyscontrol symptoms although they are also the most frequently investigated regions of the brain for these symptom categories. Future studies can make valuable contributions to the field by (1) emphasizing consistent definitions of behavioral and emotional dyscontrol, (2) assessing premorbid dyscontrol symptoms in subjects, (3) utilizing functional or structural connectivity-based imaging techniques, or (4) restricting analyses to more focused brain regions