Stability of an electron beam injected into space

Stability of electron beam injected into spac

Professor DS Kotharis Reflections on the Parallelism between Epistemological Foundations of Modern Physics and Philosophical Thought Part I: The Gita and Modern Physics

My first meeting with Dadaji, as Professor DS Kothari was dearly known to us, began with a question. I was engaged to his grandson (Ranjan) and after the engagement ceremony we went to him to get his blessings. Dadaji asked me: "Whowas Shri Rama's father?" I was taken aback at the question but when I replied that it was Dashrath, he was very happy and blessed us both. I soon learnt that he had this habit of asking simple questions to people to evoke interest in our ancient culture and heritage, especially the Bhagvad Gita

Apoptotic cell death in the lactating mammary gland is enhanced by a folding variant of α-lactalbumin

Apoptosis is essential to eliminate secretory epithelial cells during the involution of the mammary gland. The environmental regulation of this process is however, poorly understood. This study tested the effect of HAMLET (human α-lactalbumin made lethal to tumor cells) on mammary cells. Plastic pellets containing HAMLET were implanted into the fourth inguinal mammary gland of lactating mice for 3 days. Exposure of mammary tissue to HAMLET resulted in morphological changes typical for apoptosis and in a stimulation of caspase-3 activity in alveolar epithelial cells near the HAMLET pellets but not more distant to the pellet or in contralateral glands. The effect was specific for HAMLET and no effects were observed when mammary glands were exposed to native a-lactalbumin or fatty acid alone. HAMLET also induced cell death in vitro in a mouse mammary epithelial cell line. The results suggest that HAMLET can mediate apoptotic cell death in mammary gland tissu

General Scheme for Perfect Quantum Network Coding with Free Classical Communication

This paper considers the problem of efficiently transmitting quantum states through a network. It has been known for some time that without additional assumptions it is impossible to achieve this task perfectly in general -- indeed, it is impossible even for the simple butterfly network. As additional resource we allow free classical communication between any pair of network nodes. It is shown that perfect quantum network coding is achievable in this model whenever classical network coding is possible over the same network when replacing all quantum capacities by classical capacities. More precisely, it is proved that perfect quantum network coding using free classical communication is possible over a network with $k$ source-target pairs if there exists a classical linear (or even vector linear) coding scheme over a finite ring. Our proof is constructive in that we give explicit quantum coding operations for each network node. This paper also gives an upper bound on the number of classical communication required in terms of $k$, the maximal fan-in of any network node, and the size of the network.Comment: 12 pages, 2 figures, generalizes some of the results in arXiv:0902.1299 to the k-pair problem and codes over rings. Appeared in the Proceedings of the 36th International Colloquium on Automata, Languages and Programming (ICALP'09), LNCS 5555, pp. 622-633, 200

Professor DS Kotharis Reflections on the Parallelism between Epistemological Foundations of Modern Physics and Indian Philosophical Thought Part II: The Principle of complementarity and Syadvada

A favourite theme in Prof Kothari's talks and writings during his later years was the close parallelism between Bohr's principle of complementarity and Indian philosophical thought, in particular, the  Syadvada of J ain philosophy 1-6. In this part of the article , we have tried to summarize Prof Kothari's views on the subject

Neighbor Balanced Block Designs for Two Factors

The concept of Neighbor Balanced Block (NBB) designs is defined for the experimental situation where the treatments are combinations of levels of two factors and only one of the factors exhibits a neighbor effect. Methods of constructing complete NBB designs for two factors in a plot that is strongly neighbor balanced for one factor are obtained. These designs are variance balanced for estimating the direct effects of contrasts pertaining to combinations of levels of both the factors. An incomplete NBB design for two factors is also presented and is found to be partially variance balanced with three associate classes

Collaborative care model versus usual care for the management of musculoskeletal and co-existing mental health conditions: a randomised feasibility mixed-methods study.

This study aimed to assess the feasibility of a future trial comparing the collaborative care model with usual care for patients with musculoskeletal conditions and co-existing symptoms of anxiety and depression. A single-centre, parallel-arm, one-to-one, randomised controlled trial design using a mixed-methods approach was used. semistructured interviews and focus groups were conducted post intervention with all participants and staff respectively to explore acceptability towards the model and identify recommendations for improvements. An orthopaedic rehabilitation outpatient tertiary hospital. Adult patients with musculoskeletal conditions and co-existing moderate or severe symptoms of anxiety and depression attending outpatient therapy appointments. The collaborative care model consisted of a tailored management programme to facilitate the integration of care provided by physical and mental healthcare professionals. A case manager screened and coordinated targeted mental health support for participants. Participants allocated to usual care had no support from the case manager. Feasibility indicators (rates of recruitment, randomisation and retention), acceptability of clinical outcome measures, usage of additional resources and cost of intervention implementation. Of the 89 patients who provided consent to take part, 40 participants who matched the eligibility criteria were randomised to either the intervention (n=20) or usual care arm (n=20). Overall adherence to the intervention was 58.82%, while the withdrawal rate was 37.5% at 6 months. All of the 27 participants who were retained completed self-reported outcomes. Qualitative data highlighted that integrated mental health support was favourably perceived. In addition to prenegotiating protected psychology time, the need for operationalised communication between the case manager and clinicians was identified as a recommendation for a future trial. The trial and intervention were acceptable to patients and healthcare professionals. While the findings demonstrate the feasibility of trial recruitment, a future trial will require optimised retention strategies to improve adherence and withdrawal rates. NCT05018039. [Abstract copyright: © Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

An algorithm for the estimation of bounds on the emissivity and temperatures from thermal multispectral airborne remotely sensed data

The effective flux incident upon the detectors of a thermal sensor, after it has been corrected for atmospheric effects, is a function of a non-linear combination of the emissivity of the target for that channel and the temperature of the target. The sensor system cannot separate the contribution from the emissivity and the temperature that constitute the flux value. A method that estimates the bounds on these temperatures and emissivities from thermal data is described. This method is then tested with remotely sensed data obtained from NASA's Thermal Infrared Multispectral Scanner (TIMS) - a 6 channel thermal sensor. Since this is an under-determined set of equations i.e. there are 7 unknowns (6 emissivities and 1 temperature) and 6 equations (corresponding to the 6 channel fluxes), there exist theoretically an infinite combination of values of emissivities and temperature that can satisfy these equations. Using some realistic bounds on the emissivities, bounds on the temperature are calculated. These bounds on the temperature are refined to estimate a tighter bound on the emissivity of the source. An error analysis is also carried out to quantitatively determine the extent of uncertainty introduced in the estimate of these parameters. This method is useful only when a realistic set of bounds can be obtained for the emissivities of the data. In the case of water the lower and upper bounds were set at 0.97 and 1.00 respectively. Five flights were flown in succession at altitudes of 2 km (low), 6 km (mid), 12 km (high), and then back again at 6 km and 2 km. The area selected with the Ross Barnett reservoir near Jackson, Mississippi. The mission was flown during the predawn hours of 1 Feb. 1992. Radiosonde data was collected for that duration to profile the characteristics of the atmosphere. Ground truth temperatures using thermometers and radiometers were also obtained over an area of the reservoir. The results of two independent runs of the radiometer data averaged 7.03 plus or minus .70 for the first run and 7.31 plus or minus .88 for the second run. The results of the algorithm yield a temperature of 7.68 for the low altitude data to 8.73 for the high altitude data

Collaborative care model versus usual care for people with musculoskeletal conditions and co-existing anxiety and depression: protocol for a feasibility mixed-methods randomised controlled trial.

In the UK 17.8 million people have musculoskeletal pathophysiology, which becomes universal with age. Levels of discomfort and incapability correlate with symptoms of anxiety and depression. People with sufficient symptoms who seek care can benefit from collaborative diagnosis and treatment of mental and physical health organised by a case manager. This paper presents the protocol for a feasibility trial of collaborative care in an orthopaedic setting. To determine the feasibility and acceptability of providing collaborative care for patients with musculoskeletal conditions and co-existing symptoms of anxiety and depression identified on a screening tool in a physical and occupational therapy out-patient setting. A two-arm parallel-group randomised controlled trial will recruit 40 adult out-patients with at least moderate anxiety and depression, who have been referred for physiotherapy and occupational therapy. Participants will be allocated on a 1:1 ratio to collaborative care or to usual care. Co-primary outcomes will be key feasibility indicators collected at baseline and at 6 months. A qualitative study will be conducted post-intervention to explore the acceptability and potential improvements to the collaborative care model. This study will investigate the use of the collaborative care model for patients with musculoskeletal and co-existing moderate or severe levels of anxiety or depression. The results will provide important evidence to determine a future trial

Use of virtual consultations in an orthopaedic rehabilitation setting: how do changes in the work of being a patient influence patient preferences? A systematic review and qualitative synthesis.

OBJECTIVES: To systematically review qualitative studies reporting the use of virtual consultations within an orthopaedic rehabilitation setting and to understand how its use changes the work required of patients. METHODS: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis statement, we conducted a systematic review of papers to answer the research question 'How do changes in the work of being a patient when using communication technology influence patient preferences?' Electronic databases were searched for studies meeting the inclusion criteria in April 2020. RESULTS: The search strategy identified 2057 research articles from the database search. A review of titles and abstracts using the inclusion criteria yielded 21 articles for full-text review. Nine studies were included in the final analysis. Six studies explored real-time video conferencing and three explored telephone consultations. The use of communication technology changes the work required of patients. Such changes will impact on expectations for care, resources required of patients, the environment of receiving care and patient-clinician interactions. This adjustment of the work required of patients who access orthopaedic rehabilitation using communication technology will impact on their experience of receiving care. It is proposed that changes in the work of being a patient will influence preferences for or against the use of communication technology consultations for orthopaedic rehabilitation. CONCLUSION: We found that the use of communication technology changes the work of being a patient. The change in work required of patients can be both burdensome (it makes it harder for patients to access their care) and beneficial (it makes it easier for patients to access their care). This change will likely to influence preferences. Keeping the concept of patient work at the heart of pathway redesign is likely to be a key consideration to ensure successful implementation. PROSPERO REGISTRATION NUMBER: CRD42018100896