2 research outputs found
Incidence, determinants and consequences of delirium in older patients after transcatheter aortic valve implantation
Background: delirium is an event leading to negative health outcomes and increased mortality in patients. The aim of this
study is to investigate the incidence, determinants and consequences of post-operative delirium (POD) in older patients
undergoing transcatheter aortic valve implantation (TAVI).
Methods: The TAVI Care and Cure program is a prospective, observational registry in patients referred for TAVI at Erasmus
University Medical Centre. The presence of delirium was evaluated by daily clinical assessment by a geriatrician pre- and up
to 3 days post-TAVI. Mortality data were obtained from the Dutch Civil Registry.
Results: A total of 543 patients underwent TAVI between January 2014 and December 2017. Overall, the incidence of POD
was 14% (75/543 patients) but declined from 18% in 2014 to 7% in 2017 (P = 0.009). Patients who developed POD
were older (81.9 ± 5.8 versus 78.6 ± 8.3 years, P < 0.001), had higher prevalence of renal dysfunction and prior stroke (54%
versus 40%, P = 0.02; 31% versus 18%, P = 0.01) and were more often frail (32% versus 25%, P = 0.02). From a procedural
perspective, general anesthesia (odds ratios (OR), 2.31; 95% CI, 1.40–3.83; P = 0.001), non-transfemoral access (OR, 2.37;
95% CI, 1.20–4.70; P = 0.01) and longer procedural time (OR, 1.01; 95% CI, 1.01–1.02; P < 0.001) were significantly
associated with POD. One-year survival rate was 68% among patients who had suffered a POD and was 85% in patients
without a POD (hazard ratio’s 1.8 (95% CI 1.01–3.10), P = 0.045).
Conclusion: POD frequently occurs after TAVI and is associated with increased mortality. It might be speculated that patient
selection and the minimalistic approach of TAVI may reduce the frequency of delirium
Long-term follow-up of quality of life in high-risk patients undergoing transcatheter aortic valve implantation for symptomatic aortic valve stenosis
Background Transcatheter aortic valve implantation (TAVI) has become the standard treatment for patients with severe symptomatic aortic stenosis (AS) considered at very high risk for surgical aortic valve replacement. The purpose of this sub-study was to evaluate long-term (> 4 years) health-related quality of life (QoL) in octogenarians who underwent TAVI. Methods A single center observational registry in twenty patients who underwent frame analysis assessment = 4 years after TAVI. Health-related QoL was evaluated, using the Short Form-36 (SF-36), the EuroQoL-5D (EQ-5D) and the visual analogue score (EQ-VAS) questionnaires. Results The mean SF-36 subscale scores at follow-up were physical functioning 40.8 ± 26.3, role physical functioning 67.7 ± 34.9, vitality 54.6 ± 21.6, general health 52.1 ± 20.4, social functioning 63.8 ± 37.7, role emotional functioning 70.2 ± 36.0, mental health 73.2 ± 23.3 and bodily pain 80.9 ± 22.9. The mean EQ-VAS score > 4 years after TAVI was 64.7 ± 15.1. With respect to functional class, 80% of the patients were in NYHA class I/II at follow-up compared to 15% prior to TAVI. Conclusions This sub-study reports a significant improvement in functional class (NYHA) in a selected group of very elderly patients > 4 years after TAVI. Furthermore, all patients showed a satisfactory QoL despite their age and multiple comorbidities. In addition, our study reveals a lower QoL when compared with the general age matched Dutch population