3 research outputs found
Redox Chemistry and [Au(CN)2-] in the Formation of Gold Metabolites
The role of hypochlorite ion, which can be generated by the enzyme myleoperoxidase, in
the biochemistry of gold(I) anti-arthritic drugs was investigated. Sodium hypochlorite (OCl−)
directly and rapidly oxidizes AuSTm, Au(CN)2-, AuSTg (gold thioglucose) and auranofin
(Et3PAuSATg). The resulting gold(III) species were detected by an Ion Chromotography Ion-Pairing
technique that was developed to distinguish gold(I) and gold(III). Formation of Au(III) was also
demonstrated spectrophotometrically after the conversion to AuCl4−. The reactions of AuSTm,
AuSTg, and auranofin are complex and gold(III) appears only after the initial oxidation of the thiolate
(and phosphine) ligands