SYNTHESIS, CHARACTERIZATION AND EVALUATION OF ANTICANCER ACTIVITY OF SOME NEW SCHIFF BASES OF 1, 3, 4-THIADIAZOLE DERIVATIVES

Objective: N-benzylidene-5-phenyl-1, 3, 4-thiadiazol-2-amine derivatives: Synthesis and anticancer activity.Methods: In the present study five new derivatives of N-benzylidene-5-phenyl-1, 3, 4-thiadiazol-2-amine (Schiff bases containing 1, 3, 4-thiadiazole) were synthesized according to the literature methods and were characterized by FT-IR, 1H NMR spectroscopy and C, H, N analysis. Anticancer activity was evaluated in Male Swiss albino mice using Ehrlich's Ascites carcinoma cells. Compounds were administered at a dose of 25 mg/kg, body weight intraperitoneally.Results: The compounds were found to reduce tumor volume, viable cell count and increase the tumor weight (%) inhibition, ascites cells (%) inhibition, non-viable cell count and increase in life span (%ILS). All the compounds exhibited significant (P< 0.01) anticancer activity compared to control and the compound 2d & 4d was found to be most potent.Conclusion: It is concluded that synthesized Schiff bases of 2-amino-5-aryl-1, 3, 4-thiadiazoles derivatives are biologically active and developed into useful anticancer agents.Â

The Willingness to Accept Value of Statistical Life Relative to the Willingness to Pay Value: Evidence and Policy Implications

Large disparities between willingness to accept (WTA) and willingness to pay (WTP) based values of statistical life are commonly encountered in empirical studies. Standard economic theory suggests that if a public good is easily substitutable there should be no marked disparity between WTA and WTP values for the good, though the disparity increases with reduced substitutability. However, psychologists have shown that people often treat gains and losses asymmetrically and tend to require a substantially larger increase in wealth to compensate for a loss than the amount they would be willing to pay for an equivalent gain. Although most transport projects may aim to improve safety, situations arise when a relaxation of an existing regulation saves resources but increases the risk of death and injuries. A survey was recently carried out in New Zealand to determine people’s willingness to pay to reduce road risks and their willingness to accept compensation for an increase in risk. This paper reports the disparity observed between the two measures and considers some of the problems posed for policymakers. Copyright Springer 2005safety policy, willingness to accept disparity,

The value of mortality risk reductions in Delhi, India

Mortality risk valuation, Traffic safety,