Transport-Controlling Nanoscale Multilayers for Biomedical Devices

Recent advances in multilayer self-assembly have enabled the precise construction of nanocomposite ultrathin films on a variety of substrates, from large-area planar surfaces to nanoparticles. As a result, a wide range of physico-chemical properties may be represented by selecting from an array of surface preparations, molecules, assembly conditions, and post-assembly treatments. Such multilayer nanofilm assemblies are particularly attractive for use as specialized membranes for selective transport, which have many applications for separations, sensors, and drug delivery systems. In this work, nanocomposite ultrathin films built with layer-by-layer (LbL) self-assembly methods have been applied to surface modification to control interfacial behavior, including diffusion, anti-fouling, and biomimetic membranes. Transport and interfacial properties of nanocomposite membranes constructed using LbL self-assembly with synthetic and/or bio-polymers were characterized, and permeability values of clinically relevant small molecules through the nanofilms were determined. Correlations between permeability and film properties were also examined. Nanofilm coatings around 100nm thickness decreased diffusion coefficients of glucose up to five orders of magnitude, and were found to greatly affect enzymatic glucose sensor responses. Surface modification on top of the nanofilms with poly(ethylene glycol) provided anti-fouling effects. However, weak-weak polyelectrolyte multilayers (PEMs) should not be used to control transport due to their susceptibility under normal physiological conditions. Natural/biological polymers also provided multilayer film structures at the specific conditions, but their transport-limiting properties were not significant compared to synthetic PEMs. Even when covalently crosslinked, biological PEMs did not reduce the permeability of a small molecule. Finally, the predicting model of projecting analyte permeation through multi-phase nanocomposite films comprised with known diffusion coefficients was theoretically and experimentally evaluated. The modeling was matched reasonably well to experimental data. The outcomes will be the key knowledge or engineering principles to support future efforts in research and development. It is anticipated that the system developed for determining transport properties will provide a general platform for assessing new candidate materials. The theory developed will be useful in estimating transport properties of novel nanocomposite materials that may be interesting in a broad array of chemical and biological systems, from analytical separations to implantable biomedical applications, and will provide useful design rules for materials and fabrication process selection

Cost Estimate Modeling of Transportation Management Plans for Highway Projects, Research Report 11-24

Highway rehabilitation and reconstruction projects frequently cause road congestion and increase safety concerns while limiting access for road users. State Transportation Agencies (STAs) are challenged to find safer and more efficient ways to renew deteriorating roadways in urban areas. To better address the work zone issues, the Federal Highway Administration published updates to the Work Zone Safety and Mobility Rule. All state and local governments receiving federal aid funding were required to comply with the provisions of the rule no later than October 12, 2007. One of the rule’s major elements is to develop and implement Transportation Management Plans (TMPs). Using well-developed TMP strategies, work zone safety and mobility can be enhanced while road user costs can be minimized. The cost of a TMP for a road project is generally considered a high-cost item and, therefore, must be quantified. However, no tools or systematic modeling methods are available to assist agency engineers with TMP cost estimating. This research included reviewing TMP reports for recent Caltrans projects regarding state-of-the-art TMP practices and input from the district TMP traffic engineers. The researchers collected Caltrans highway project data regarding TMP cost estimating. Then, using Construction Analysis for Pavement Rehabilitation Strategies (CA4PRS) software, the researchers performed case studies. Based on the CA4PRS outcomes of the case studies, a TMP strategy selection and cost estimate (STELCE) model for Caltrans highway projects was proposed. To validate the proposed model, the research demonstrated an application for selecting TMP strategies and estimating TMP costs. Regarding the model’s limitation, the proposed TMP STELCE model was developed based on Caltrans TMP practices and strategies. Therefore, other STAs might require adjustments and modifications, reflecting their TMP processes, before adopting this model. Finally, the authors recommended that a more detailed step-by-step TMP strategy selection and cost estimate process be included in the TMP guidelines to improve the accuracy of TMP cost estimates

Competing states for the fractional quantum Hall effect in the 1/3-filled second Landau level

In this work, we investigate the nature of the fractional quantum Hall state in the 1/3-filled second Landau level (SLL) at filling factor $\nu=7/3$ (and 8/3 in the presence of the particle-hole symmetry) via exact diagonalization in both torus and spherical geometries. Specifically, we compute the overlap between the exact 7/3 ground state and various competing states including (i) the Laughlin state, (ii) the fermionic Haffnian state, (iii) the antisymmetrized product state of two composite fermion seas at 1/6 filling, and (iv) the particle-hole (PH) conjugate of the $Z_4$ parafermion state. All these trial states are constructed according to a guiding principle called the bilayer mapping approach, where a trial state is obtained as the antisymmetrized projection of a bilayer quantum Hall state with interlayer distance $d$ as a variational parameter. Under the proper understanding of the ground-state degeneracy in the torus geometry, the $Z_4$ parafermion state can be obtained as the antisymmetrized projection of the Halperin (330) state. Similarly, it is proved in this work that the fermionic Haffnian state can be obtained as the antisymmetrized projection of the Halperin (551) state. It is shown that, while extremely accurate at sufficiently large positive Haldane pseudopotential variation $\delta V_1^{(1)}$, the Laughlin state loses its overlap with the exact 7/3 ground state significantly at $\delta V_1^{(1)} \simeq 0$. At slightly negative $\delta V_1^{(1)}$, it is shown that the PH-conjugated $Z_4$ parafermion state has a substantial overlap with the exact 7/3 ground state, which is the highest among the above four trial states.Comment: 22 pages, 5 figure

Fabrication and characterization of silicon wire solar cells having ZnO nanorod antireflection coating on Al-doped ZnO seed layer

In this study, we have fabricated and characterized the silicon [Si] wire solar cells with conformal ZnO nanorod antireflection coating [ARC] grown on a Al-doped ZnO [AZO] seed layer. Vertically aligned Si wire arrays were fabricated by electrochemical etching and, the pn junction was prepared by spin-on dopant diffusion method. Hydrothermal growth of the ZnO nanorods was followed by AZO film deposition on high aspect ratio Si microwire arrays by atomic layer deposition [ALD]. The introduction of an ALD-deposited AZO film on Si wire arrays not only helps to create the ZnO nanorod arrays, but also has a strong impact on the reduction of surface recombination. The reflectance spectra show that ZnO nanorods were used as an efficient ARC to enhance light absorption by multiple scattering. Also, from the current-voltage results, we found that the combination of the AZO film and ZnO nanorods on Si wire solar cells leads to an increased power conversion efficiency by more than 27% compared to the cells without it. © 2012 Baek et al.1

Association between work-related health problems and job insecurity in permanent and temporary employees

OBJECTIVES: This research was conducted with an aim of determining the correlation between job insecurity and an employee’s work-related health problems among permanent and temporary workers. METHODS: Using the data from the First Korean Working Conditions Survey conducted in 2006, a total of 7,071 workers, excluding employers and the self-employed, were analyzed. Work-related health problems were categorized as backache, headache, abdominal pain, muscular pain, stress, fatigue, insomnia, anxiety or depression. Each problem was then analyzed for its relationship to job insecurity through logistic regression analysis. RESULTS: Among the 7,071 workers, 5,294 (74.9%) were permanent workers and 1,777 (25.1%) were temporary workers. For the permanent workers, presence of high or moderate job insecurity appeared more closely linked to backache, headache, abdominal pain, muscular pain, stress, fatigue, insomnia, anxiety, and depression compared to absence of job insecurity. However, for the temporary workers, only depression appeared to be associated with the presence of high job insecurity. CONCLUSION: The study showed that the presence of job insecurity is correlated with work-related health problems. The deleterious effects of job insecurity appeared to be stronger in permanent than temporary workers. Additional research should investigate ways to effectively reduce job insecurity