STUDIES ON THE REGULATORY ROLES OF MICRORNA-27A AND MICRORNA-200B IN ACTIVATED RODENT MICROGLIA

Ph.DDOCTOR OF PHILOSOPH

Breast Cancer: From Transcriptional Control to Clinical Outcome

Breast cancer is the most common malignancy in women worldwide. The risk of breast cancer in women increases with age, and this is partly attributable to the accumulation of genetic lesions. Growing evidence demonstrates the role played by epigenetic modifiers and the tumor microenvironment in contributing to the increased risk of breast cancer. This chapter provides a comprehensive overview of the epigenetic regulatory signatures that impact the well-studied signaling pathways in breast tissues. Additionally, we will also delve into the therapeutic and diagnostic potential of noncoding RNAs in breast cancer