1 research outputs found
Recent incidence of type 1 diabetes mellitus in children 0β14 years in Newfoundland and Labrador, Canada climbs to over 45/100,000: a retrospective time trend study
Background: To study and update the provincial incidence of type 1 diabetes mellitus (T1DM) in Newfoundland
and Labrador (NL), a province of Canada with a very high incidence previously reported in 2006, and one of
the highest incidences reported worldwide. This is a retrospective time trend study of the incidence of T1DM,
in children aged 0β14 years from 1987β2010 inclusive.
Findings: Over the study period 931 children aged 0β14 years were diagnosed with T1DM. The incidence of
T1DM in this population over the period 1987 β 2010 inclusive was 37.7 per 100,000 per year (95% CI 35. 3, 40.2)
The incidence from 2007β2010 was 49.9 per 100,000 per year (95% CI 42.2, 57.6). The incidence over this 24 year
period increased by a factor of 1.03 per 100,000 per year.
Conclusion: NL has one of the highest incidences of T1DM reported worldwide. Potential reasons for the very high
incidence could be related to the unique genetic background of the population, northern latitude and vitamin D
insufficiency, low breastfeeding rates, and high rates of cesarean section