22 research outputs found

    Ov2 is a modulator of OvHV-2 RTA mediated gene expression

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    Searching for vector dark matter with an optomechanical accelerometer

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    We consider using optomechanical accelerometers as resonant detectors for ultralight dark matter. As a concrete example, we describe a detector based on a silicon nitride membrane fixed to a beryllium mirror, forming an optical cavity. The use of different materials gives access to forces proportional to baryon (B) and lepton (L) charge, which are believed to be coupling channels for vector dark matter particles ("dark photons"). The cavity meanwhile provides access to quantum-limited displacement measurements. For a centimeter-scale membrane pre-cooled to 10 mK, we argue that sensitivity to vector B-L dark matter can exceed that of the E\"{o}t-Wash experiment in integration times of minutes, over a fractional bandwidth of ∼0.1%\sim 0.1\% near 10 kHz (corresponding to a particle mass of 10−1010^{-10}eV/c2^2). Our analysis can be translated to alternative systems such as levitated particles, and suggests the possibility of a new generation of table-top experiments

    The Lantern Vol. 45, No. 1, November 1978

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    • Here is the Dance • To V.E.H. • The Hard Fist of the North • Early Ridicule • Spectrum - October 6, 1978 • Finally Someone Looks • Windjammer • Bereft • Waiting • Solitary Season • Drifting Downstream • The Dirtiest Joke • The Mannequin Factory • Me • When I am Famous • A Letter to John Hansen • Who Said the Sound of Laughter is Nice? • Throwing Back Her Hair • Don\u27t Let the Cold Become You • Sister • Marxist Drama • Fleeting Love • Music of Spain • (A Selection of Happy Poems) • Sterling St. Jacques • Winter, Verse II • Aventure Chez Le Psychiatre • For Marya • The Night Train • A Rude Awakeninghttps://digitalcommons.ursinus.edu/lantern/1113/thumbnail.jp

    The Lantern Vol. 46, No. 1, December 1979

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    • Visions in Chains • The Bean • Who Can We Watch Tonite? • Night Glider • The Hurricane • Crisp New Paper • Compassion • Loneliness • 301 • Ode to Man • Unsteady Hands • The Beachcomber • The Pounce • Graveyard Shift • Houston Refineries • Haiku • The End of the Game • A Rose • Ode to a Ziffle • To Carson McCullers • In the May Month • Ghostly Chanting • Travel Excerpts • Face in the Crowd • Waiting in an Airport • A Taste of Winter\u27s Embracehttps://digitalcommons.ursinus.edu/lantern/1115/thumbnail.jp

    The Lantern Vol. 46, No. 2, April 1980

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    • The Voyage to Man\u27s Destiny • If I Could Keep the Times • Barstool Blues • I Didn\u27t Know • Felonious, Friend • Cool Ride • Georgia • Let Us Eat and Drink • In a Field • New Born Foal • Union to Freedom • In the Woods • Anthropomorphism • Runner • C.C. • Lake Attempt • A Fuzzy Blue Line • Trust Me • Haven\u27t We Met Before? • Rationality • Expecting Me • Short Storyhttps://digitalcommons.ursinus.edu/lantern/1116/thumbnail.jp

    Comprehensive Risk Assessment of Heavy Metal Accumulation in Surface Sediment of Lake Tortum Based on Ecological Indices

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    In this study, ecological risks arising from the accumulation of some heavy metals in surface sediments of Lake Tortum are discussed based on the use of ecological indices, such as enrichment factor (EF), contamination factor (CF), pollution load index (PLI), potential ecological risk index (PER) and the mean probable effect concentration quotient (mPEC-Q). Sediment samples were collected from six different sites using Van Veen grab and heavy metal and organic carbon content of sediments were determined. Results testify to the existence of minimal to moderate contamination in lake sediment. The highest value for the enrichment factor pertains to Cd caused by the use of fossil fuels in settlement areas in the lake catchment. PLI and PER estimations, on the other hand, reveals the presence of low heavy metals-induced ecological risk in lake sediments. Ranging between 15% and 29%, mPEC-Q values are indicative of the fact that Lake Tortum is a low-moderate priority site in terms of toxicity level caused by heavy metals

    Structural basis of nucleotide sugar transport across the Golgi membrane

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    Glycosylation is a fundamental cellular process that, in eukaryotes, occurs in the lumen of both the Golgi apparatus and the endoplasmic reticulum1. Nucleotide sugar transporters (NSTs) are an essential component of the glycosylation pathway, providing the diverse range of substrates required for the glycosyltransferases2,3. NSTs are linked to several developmental and immune disorders in humans, and in pathogenic microbes they have an important role in virulence4,5,6,7,8. How NSTs recognize and transport activated monosaccharides, however, is currently unclear. Here we present the crystal structure of an NST, the GDP–mannose transporter Vrg4, in both the substrate-free and the bound states. A hitherto unobserved requirement of short-chain lipids in activating the transporter supports a model for regulation within the highly dynamic membranes of the Golgi apparatus. Our results provide a structural basis for understanding nucleotide sugar recognition, and provide insights into the transport and regulatory mechanism of this family of intracellular transporters
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