1,484 research outputs found
Feasibility Test of the MedaCube
Poor adherence is a significant barrier to achieve better patient outcomes. Rates of non-adherence approach 40% resulting in 10% of all emergency department visits and 23% of admissions into skilled nursing facilities. Many factors contribute to medication non-adherence including psychological and memory disorders, aging and pill burden. The MedaCube is a medication management system intended to help solve unintentional medication non-adherence. The device is designed to dispense scheduled and as-needed oral medications. The MedaCube provides audio and visual prompts alerting subjects to administer their medications. Caregivers receive notification of missed doses, late doses and refill requests. The null hypothesis is that use of the MedaCube results in no difference in medication adherence when compared with six month prior adherence in individual subjects
Exploiting Machine Learning to Subvert Your Spam Filter
Using statistical machine learning for making security decisions introduces new vulnerabilities in large scale systems. This paper shows how an adversary can exploit statistical machine learning, as used in the SpamBayes spam filter, to render it useless—even if the adversary’s access is limited to only 1 % of the training messages. We further demonstrate a new class of focused attacks that successfully prevent victims from receiving specific email messages. Finally, we introduce two new types of defenses against these attacks.
Two-loop RGEs with Dirac gaugino masses
The set of renormalisation group equations to two loop order for general
supersymmetric theories broken by soft and supersoft operators is completed. As
an example, the explicit expressions for the RGEs in a Dirac gaugino extension
of the (N)MSSM are presented.Comment: 10 pages + 24 pages of RGEs in appendix; no figure
Metabolism of [p-180]-Phenacetin: The Mechanism of Activation of Phenacetin to Reactive Metabolites in Hamsters
Vortex wandering in a forest of splayed columnar defects
We investigate the scaling properties of single flux lines in a random
pinning landscape consisting of splayed columnar defects. Such correlated
defects can be injected into Type II superconductors by inducing nuclear
fission or via direct heavy ion irradiation. The result is often very efficient
pinning of the vortices which gives, e.g., a strongly enhanced critical
current. The wandering exponent \zeta and the free energy exponent \omega of a
single flux line in such a disordered environment are obtained analytically
from scaling arguments combined with extreme-value statistics. In contrast to
the case of point disorder, where these exponents are universal, we find a
dependence of the exponents on details in the probability distribution of the
low lying energies of the columnar defects. The analytical results show
excellent agreement with numerical transfer matrix calculations in two and
three dimensions.Comment: 11 pages, 9 figure
Sfermion masses in Nelson-Strassler type of models: SUSY standard models coupled with SCFTs
We study soft SUSY breaking parameters in the Nelson-Strassler type of
models: SUSY standard models coupled with SCFTs. In this type of models, soft
SUSY breaking parameters including sfermion masses can be suppressed around the
decoupling scale of SCFTs. We clarify the condition to derive exponential
suppression of sfermion masses within the framework of pure SCFTs. Such
behavior is favorable for degeneracy of sfermion masses. However, the realistic
sfermion masses are not quite degenerate due to the gauge couplings and the
gaugino masses in the SM sector. We show the sfermion mass spectrum obtained in
such models. The aspect of suppression for the soft SUSY breaking parameters is
also demonstrated in an explicit model. We also give a mechanism generating the
-term of the Electro-Weak scale by a singlet field coupled with the SCFT.Comment: 28 pages, 8 figures, LaTeX file; corrected typos and references adde
Virus shapes and buckling transitions in spherical shells
We show that the icosahedral packings of protein capsomeres proposed by
Caspar and Klug for spherical viruses become unstable to faceting for
sufficiently large virus size, in analogy with the buckling instability of
disclinations in two-dimensional crystals. Our model, based on the nonlinear
physics of thin elastic shells, produces excellent one parameter fits in real
space to the full three-dimensional shape of large spherical viruses. The
faceted shape depends only on the dimensionless Foppl-von Karman number
\gamma=YR^2/\kappa, where Y is the two-dimensional Young's modulus of the
protein shell, \kappa is its bending rigidity and R is the mean virus radius.
The shape can be parameterized more quantitatively in terms of a spherical
harmonic expansion. We also investigate elastic shell theory for extremely
large \gamma, 10^3 < \gamma < 10^8, and find results applicable to icosahedral
shapes of large vesicles studied with freeze fracture and electron microscopy.Comment: 11 pages, 12 figure
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