Which rhizobia nodulate which legumes in New Zealand soils?

Recent work which genotypically characterised rhizobia of native, crop and weed legumes in New Zealand and examined their cross-nodulation ability is reviewed and related to earlier work with focus on New Zealand pasture systems. The New Zealand native legumes were exclusively effectively nodulated by novel strains of Mesorhizobium which did not nodulate crop or weed legumes. Clovers, lucerne, Lotus and grain legumes were effectively nodulated by different genera, species and biovars of rhizobia primarily originating from inoculum. Rhizobial symbionts of white clover have established over wide areas in New Zealand. Weed legumes are effectively nodulated by different genera/species of rhizobia depending on species. Bradyrhizobia that cross-nodulate lupins, gorse, European broom and tagasaste are widespread in New Zealand

Appropriateness of antibiotic prescribing in the Emergency Department

Background Antibiotics are some of the most commonly prescribed drugs in the Emergency Department (ED) and yet data describing the overall appropriateness of antibiotic prescribing in the ED is scarce. Objectives To describe the appropriateness of antibiotic prescribing in the ED. Methods A retrospective, observational study of current practice. All patients who presented to the ED during the study period and were prescribed at least one antibiotic were included. Specialists from Infectious Disease, Microbiology and Emergency Medicine and a Senior Pharmacist assessed antibiotic appropriateness against evidence-based guidelines. Results A total of 1019 (13.6%) of patient presentations involved the prescription of at least one antibiotic. Of these, 640 (62.8%) antibiotic prescriptions were assessed as appropriate, 333 (32.7%) were assessed as inappropriate and 46 (4.5%) were deemed to be not assessable. Adults were more likely to receive an inappropriate antibiotic prescription than children (36.9% versus 22.9%; difference 14.1%, 95% CI 7.2%–21.0%). Patients who met quick Sepsis-related Organ Failure Assessment (qSOFA) criteria were more likely to be prescribed inappropriate antibiotics (56.7% versus 36.1%; difference 20.5%, 95% CI, 2.4%–38.7%). There was no difference in the incidence of appropriate antibiotic prescribing based on patient gender, disposition (admitted/discharged), reason for antibiotic administration (treatment/prophylaxis) or time of shift (day/night). Conclusions Inappropriate administration of antibiotics can lead to unnecessary adverse events, treatment failure and antimicrobial resistance. With over one in three antibiotic prescriptions in the ED being assessed as inappropriate, there is a pressing need to develop initiatives to improve antibiotic prescribing to prevent antibiotic-associated patient and community harms.No Full Tex

Cosmological Shocks in Adaptive Mesh Refinement Simulations and the Acceleration of Cosmic Rays

We present new results characterizing cosmological shocks within adaptive mesh refinement N-Body/hydrodynamic simulations that are used to predict non-thermal components of large-scale structure. This represents the first study of shocks using adaptive mesh refinement. We propose a modified algorithm for finding shocks from those used on unigrid simulations that reduces the shock frequency of low Mach number shocks by a factor of ~3. We then apply our new technique to a large, (512 Mpc/h)^3, cosmological volume and study the shock Mach number (M) distribution as a function of pre-shock temperature, density, and redshift. Because of the large volume of the simulation, we have superb statistics that results from having thousands of galaxy clusters. We find that the Mach number evolution can be interpreted as a method to visualize large-scale structure formation. Shocks with Mach<5 typically trace mergers and complex flows, while 520 generally follow accretion onto filaments and galaxy clusters, respectively. By applying results from nonlinear diffusive shock acceleration models using the first-order Fermi process, we calculate the amount of kinetic energy that is converted into cosmic ray protons. The acceleration of cosmic ray protons is large enough that in order to use galaxy clusters as cosmological probes, the dynamic response of the gas to the cosmic rays must be included in future numerical simulations.Comment: 15 pages, 14 figures, Accepted to ApJ, minor changes mad