3 research outputs found
Therapeutic percutaneous transluminal angioplasty with a stenting procedure of a stenosed great cardiac vein in a patient with dilated cardiomyopathy submitted to biventricular pacemaker implantation
AbstractCardiac resynchronization therapy (CRT) is recommended for select patients with dilated cardiomyopathy (DCM). Here, we describe the case of a 62-year-old patient with non-ischemic dilated cardiomyopathy, of functional class NYHA III, with left bundle branch block (LBBB) and 90% stenosis of the great cardiac vein (GCV), which was revealed as a result of coronary sinus venography during a CRT-P implantation procedure. A left-ventricular electrode was introduced to the posterolateral vein. Following CRT-P implantation a partial improvement was observed. In view of the patient's remaining apical segment contractility disorder and the coexistence of great cardiac vein stenosis, a hypothesis was put forward that the cause of these disorders was passive hyperemia of a portion of the left ventricle. Successful GCV angioplasty and BMS implantation was followed by clinical and echocardiographic improvement.Two months after the angioplasty, occlusion of the vein was detected, but repeated percutaneous treatment was unsuccessful
Post-dilatation intravascular brachytherapy trials on hypercholesterolemic rabbits using 32P-phosphate solutions in angioplasty balloons
Response of peripheral arteries to post-dilatation intravascular brachytherapy (IVBT) using 32P liquid sources was studied in a rabbit model. The applied sources were angioplasty balloons filled with aqueous solutions of Na2H32PO4, NaCl and iodinated contrast. Dose distribution was calibrated by thermoluminescence dosimetry. The uncertainty of in vitro determinations of the activity–dose dependence was ± 15–30%. The animal experiments were performed on rabbits with induced hypercholesterolemia. The 32P sources were introduced into a randomly chosen (left or right) iliac artery, immediately after balloon injury. Due to the low specific activity of the applied sources, the estimated 7–49 Gy doses on the internal artery surface required 30–100 min irradiations. A symmetric, balloon-occluded but non-irradiated artery of the same animal served as control. Radiation effects were evaluated by comparing the thicknesses of various components of irradiated versus untreated artery walls of each animal. The treatment was well tolerated by the animals. The effects of various dose ranges could be distinguished although differences in individual biological reactions were large. Only the 49 Gy dose at “zero” distance (16 Gy at 1.0 mm from the balloon surface) reduced hypertrophy in every active layer of the artery wall. The cross-sectional intimal thicknesses after 7, 12, 38 and 49 Gy doses were 0.277, 0.219, 0.357 and 0.196 mm2 respectively, versus 0.114, 0.155, 0.421 and 0.256 mm2 in controls (p < 0.05). The lowest radiation dose on the intima induced the opposite effect. Edge intimal hyperplasia was not avoided, which agrees with other reports. The edge restenosis and the variability of individual response to identical treatment conditions must be considered as limitations of the post-dilatation IVBT method. Only application of highest irradiation doses was effective. The irradiation dose should be planned and calculated for adventitia