Associação das estratégias de coping com a ocorrência de lesões desportivas: revisão bibliográfica

Projeto de Graduação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Licenciado em FisioterapiaIntrodução: todos os atletas em geral, independentemente da modalidade e nível desportivo, experienciam vários tipos de stress, podendo influenciar o seu rendimento, e/ou ser causador do aparecimento de lesões. Objetivo: analisar a existência de estratégias de Coping que possam interferir com a ocorrência de lesões desportivas. Metodologia: a pesquisa foi realizada nas bases de dados Pubmed, Cohrane e PEDro. A análise da qualidade metodológica foi efetuada com o checklist Strengthening the Reporting of Observational Studies in Epidemiology (STROBE). Resultados: foram selecionados 5 artigos observacionais, respeitando os critérios de elegibilidade. Da totalidade da amostra de 934 atletas, 843 integraram os estudos. Estes atletas, de ambos os géneros eram praticantes de dança, Rugby e futebol, com idades compreendidas entre 12 e 28 anos. As estratégias de coping, avaliadas pelo Athletic Coping Skills Inventory–28 (ACSI-28), reduziram significativamente a probabilidade de ocorrer lesões desportivas quando ajustadas a outras variáveis. Diversos constructos do inventário Brief- COPE têm influência no risco ou na proteção de ocorrência de lesões. E, os scores de stress, avaliados com a Escala Visual analógica (EVA), são distintos aquando da presença de lesões. Conclusão: a utilização de estratégias de coping poderá ser uma mais-valia nos momentos lesivos.Background: all athletes in general, regardless of the modality and sport level, experience various types of stress, which can influence their performance, and/or cause the appearance of injuries.Objective: to analyze the existence of Coping strategies that may interfere with the occurrence of sports injuries Methodology: the search was carried out in Pubmed, Cohrane and PEDro databases. Methodological quality analysis was performed using the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) checklist.Results: 5 observational articles were selected, respecting the eligibility criteria. Of the total sample of 934 athletes, 843 participated in the studies. These athletes, of both genders, practiced dance, rugby, and football, aged between 12 and 28 years. Coping strategies, evaluated by the Athletic Coping Skills Inventory–28 (ACSI-28), significantly reduced the likelihood of sports injuries occurring when adjusted for other variables. Several constructs of the Brief-COPE inventory have an influence on the risk or protection of the occurrence of injuries. And, the stress scores, evaluated with the Visual Analog Scale (VAS), are different in the presence of injuries Conclusion: the use of coping strategies can be an asset in harmful moments.N/

Genome-wide identification of splicing quantitative trait loci (sQTLs) in diverse ecotypes of Arabidopsis thaliana

Alternative splicing (AS) of pre-mRNAs contributes to transcriptome diversity and enables plants to generate different protein isoforms from a single gene and/or fine-tune gene expression during different development stages and environmental changes. Although AS is pervasive, the genetic basis for differential isoform usage in plants is still emerging. In this study, we performed genome-wide analysis in 666 geographically distributed diverse ecotypes of Arabidopsis thaliana to identify genomic regions [splicing quantitative trait loci (sQTLs)] that may regulate differential AS. These ecotypes belong to different microclimatic conditions and are part of the relict and non-relict populations. Although sQTLs were spread across the genome, we observed enrichment for trans-sQTL (trans-sQTLs hotspots) on chromosome one. Furthermore, we identified several sQTL (911) that co-localized with trait-linked single nucleotide polymorphisms (SNP) identified in the Arabidopsis genome-wide association studies (AraGWAS). Many sQTLs were enriched among circadian clock, flowering, and stress-responsive genes, suggesting a role for differential isoform usage in regulating these important processes in diverse ecotypes of Arabidopsis. In conclusion, the current study provides a deep insight into SNPs affecting isoform ratios/genes and facilitates a better mechanistic understanding of trait-associated SNPs in GWAS studies. To the best of our knowledge, this is the first report of sQTL analysis in a large set of Arabidopsis ecotypes and can be used as a reference to perform sQTL analysis in the Brassicaceae family. Since whole genome and transcriptome datasets are available for these diverse ecotypes, it could serve as a powerful resource for the biological interpretation of trait-associated loci, splice isoform ratios, and their phenotypic consequences to help produce more resilient and high yield crop varieties

New drugs and technologies, intravenous anaesthesia is on the move (again).

Although well established in clinical practice, both propofol and midazolam have limitations. New hypnotics with different and potentially superior pharmacokinetics and pharmacodynamics are under development. These include the benzodiazepine receptor agonists CNS7056 and JM-1232 (-), the etomidate-based methoxycarbonyl-etomidate and carboetomidate, the propofol-related structures PF0713 and fospropofol, and THRX-918661/AZD3043. The basic pharmacology and the initial anaesthesia studies for each of these agents are reviewed. Several of the agents (CNS7056, THRX-918661/AZD3043, and fospropofol) have reached the stage of clinical trials. To be successful, novel compounds need to establish clear clinical advantages over existing agents and where possible the new agents are discussed in this context. Computer-controlled drug administration offers the ability to automatically implement infusion schemes too complex for manual use and the possibility of linking patient monitoring to administration to enhance patient safety