The Arab American experience with diabetes: Perceptions, myths and implications for culturally-specific interventions

Culturally-specific lifestyle diabetes prevention programs require an assessment of population disease perceptions and cultural influences on health beliefs and behaviors. The primary objectives were to assess Arab Americans’ knowledge and perceptions of diabetes and their preferences for a lifestyle intervention

Triple domestic heat recovery system: thermal modeling and parametric study

International audienc

Domestic thermoelectric cogeneration drying system: Thermal modeling and case study

The demand for reducing fuel consumption and mitigating exhaust fumes accountable for the greenhouse effect push toward developing efficient energy recovery systems. Optimizing the heat recovery process can be achieved by adding multi-recovery stages. In this frame, the present work suggests a new multi-stage recovery system for heating water and air and generating electricity. The concept of the system is applied to the exhaust gases of a chimney. A complete thermal modeling of the system is drawn. Then a case study is carried out for three different fed fuels (diesel, coal, wood). The results show that when diesel is used water temperature achieved 351 K and 240 W electric power is generated. Moreover, a 0.16 m2 heat recovery heat exchanger area is required to heat air to 363 K at an air flow rate of 0.0076 kg/s. Such system can recover up to 84% of the energy lost to the environment when wood is utilized as a fed fuel

Shedding light on the formation of the pre-biotic molecule formamide with ASAI

Formamide (NH2CHO) has been proposed as a pre-biotic precursor with a key role in the emergence of life on Earth. While this molecule has been observed in space, most of its detections correspond to high-mass star-forming regions. Motivated by this lack of investigation in the low-mass regime, we searched for formamide, as well as isocyanic acid (HNCO), in 10 low- and intermediate-mass pre-stellar and protostellar objects. The present work is part of the IRAM Large Programme ASAI (Astrochemical Surveys At IRAM), which makes use of unbiased broadband spectral surveys at millimetre wavelengths. We detected HNCO in all the sources and NH2CHO in five of them. We derived their abundances and analysed them together with those reported in the literature for high-mass sources. For those sources with formamide detection, we found a tight and almost linear correlation between HNCO and NH2CHO abundances, with their ratio being roughly constant -between 3 and 10- across 6 orders of magnitude in luminosity. This suggests the two species are chemically related. The sources without formamide detection, which are also the coldest and devoid of hot corinos, fall well off the correlation, displaying a much larger amount of HNCO relative to NH2CHO. Our results suggest that, while HNCO can be formed in the gas phase during the cold stages of star formation, NH2CHO forms most efficiently on the mantles of dust grains at these temperatures, where it remains frozen until the temperature rises enough to sublimate the icy grain mantles. We propose hydrogenation of HNCO as a likely formation route leading to NH2CHO.Comment: 26 pages, 9 figures. Accepted by Monthly Notices of the Royal Astronomical Societ

Investigation of correlations between clinical signs and pathological findings in cats and dogs with inflammatory bowel disease

This paper compares the correlation between the clinical signs and the histopathological observations of the entire intestine in cats and dogs with inflammatory bowel disease (IBD). To perform this study, hospital records of 53 dogs and 20 cats of different sex, ages, and breed diagnosed with IBD following the histopathological criteria of the World Small Animal Veterinary Association (WSAVA) were evaluated. The results obtained in this study did show correlations between some clinical signs and the histopathological assessment of dogs and cats with IBD. Therefore, a slight association between diarrhea and lacteal dilation in the small bowel, and diarrhea and desquamation in the large bowel of dogs with IBD was seen, but no other associations were found between the rest of the lesions and symptoms. In contrast, cats only showed a correlation between anorexia with villous stunting and villous epithelial injury, without correspondence among other clinical signs and lesions. The results of this study propose that the evaluation of IBD can be complicated, especially with the use of retrospective records of archived intestinal biopsies and subjective clinical and histopathologic decisions

Symbolic Implementation of Connectors in BIP

BIP is a component framework for constructing systems by superposing three layers of modeling: Behavior, Interaction, and Priority. Behavior is represented by labeled transition systems communicating through ports. Interactions are sets of ports. A synchronization between components is possible through the interactions specified by a set of connectors. When several interactions are possible, priorities allow to restrict the non-determinism by choosing an interaction, which is maximal according to some given strict partial order. The BIP component framework has been implemented in a language and a tool-set. The execution of a BIP program is driven by a dedicated engine, which has access to the set of connectors and priority model of the program. A key performance issue is the computation of the set of possible interactions of the BIP program from a given state. Currently, the choice of the interaction to be executed involves a costly exploration of enumerative representations for connectors. This leads to a considerable overhead in execution times. In this paper, we propose a symbolic implementation of the execution model of BIP, which drastically reduces this overhead. The symbolic implementation is based on computing boolean representation for components, connectors, and priorities with an existing BDD package

Relativistic Aharonov-Casher Phase in Spin One

The Aharonov-Casher (AC) phase is calculated in relativistic wave equations of spin one. The AC phase has previously been calculated from the Dirac-Pauli equation using a gauge-like technique \cite{MK1,MK2}. In the spin-one case, we use Kemmer theory (a Dirac-like particle theory) to calculate the phase in a similar manner. However the vector formalism, the Proca theory, is more widely known and used. In the presence of an electromagnetic field, the two theories are `equivalent' and may be transformed into one another. We adapt these transformations to show that the Kemmer theory results apply to the Proca theory. Then we calculate the Aharonov-Casher phase for spin-one particles directly in the Proca formalism.Comment: 12 page

Leaky ryanodine receptors contribute to diaphragmatic weakness during mechanical ventilation

Ventilator-induced diaphragmatic dysfunction (VIDD) refers to the diaphragm muscle weakness that occurs following prolonged controlled mechanical ventilation (MV). The presence of VIDD impedes recovery from respiratory failure. However, the pathophysiological mechanisms accounting for VIDD are still not fully understood. Here, we show in human subjects and a mouse model of VIDD that MV is associated with rapid remodeling of the sarcoplasmic reticulum (SR) Ca2+ release channel/ryanodine receptor (RyR1) in the diaphragm. The RyR1 macromolecular complex was oxidized, S-nitrosylated, Ser-2844 phosphorylated, and depleted of the stabilizing subunit calstabin1, following MV. These posttranslational modifications of RyR1 were mediated by both oxidative stress mediated by MV and stimulation of adrenergic signaling resulting from the anesthesia. We demonstrate in the murine model that such abnormal resting SR Ca2+ leak resulted in reduced contractile function and muscle fiber atrophy for longer duration of MV. Treatment with β-adrenergic antagonists or with S107, a small molecule drug that stabilizes the RyR1–calstabin1 interaction, prevented VIDD. Diaphragmatic dysfunction is common in MV patients and is a major cause of failure to wean patients from ventilator support. This study provides the first evidence to our knowledge of RyR1 alterations as a proximal mechanism underlying VIDD (i.e., loss of function, muscle atrophy) and identifies RyR1 as a potential target for therapeutic intervention