Aplikasi Fuzzy Linear Programming untuk Produksi Bola Lampu di PT XYZ

PT XYZ merupakan Perusahaan yang memproduksi bola lampu. Permintaan pasar yang tinggi menyebabkan Perusahaan tidak dapat memenuhi permintaan tersebut dikarenakan perencanaan produksi yang tidak optimal. Dari data, diketahui bahwa Perusahaan tidak dapat memenuhi permintaan pasar pada produk bola lampu merek Stanlee Star G-20 sebesar 8% dan S-25 sebesar 18,32% sedangkan bola lampu merek Dai-Ichi G40 diproduksi melebihi permintaan pasar sebesar 9,1%. Hal ini menyebabkan Perusahaan kehilangan opportunity profit. Perencanaan produksi bola lampu diteliti dengan tujuan agar Perusahaan dapat memenuhi permintaan pasar sesuai dengan keterbatasan sumber daya yang tersedia. Metode perencanaan produksi yang digunakan adalah metode fuzzy linear programming dengan metode simpleks. Dengan menggunakan Fuzzy Linear Programming dapat diperoleh nilai optimum jumlah produk bola lampu yang diproduksi sesuai permintaan pasar dan sesuai dengan keterbatasan sumber daya produksi. Sumber daya yang diteliti adalah kapasitas produksi, waktu kerja, dan bahan baku. Nilai interval logika fuzzy yang digunakan adalah t = 0 dan t = 1. Penyelesaian metode simpleks dilakukan dengan menggunakan software LINGO 13. Hasil penilitian menunjukkan bahwa permintaan pasar terpenuhi untuk ketiga merek bola lampu. Kapasitas produksi mencukupi sehingga tidak diperlukan penambahan jumlah mesin, sedangkan waktu kerja dan bahan baku tidak mencukupi. Perusahaan dapat menentukan jumlah bahan baku dan waktu kerja yang diperlukan dengan menggunakan nilai λ yaitu sebesar 0,536. Nilai λ digunakan untuk menentukan skala terbesar nilai interval t untuk setiap kendala bahan baku dan waktu kerja yaitu 0,464. Aplikasi fuzzy linear programming meningkatkan keuntungan sebesar 7,39% dari konsep linear programming biasa

Aktivitas Antioksidan Ekstrak Etanol Buah, Daun, Batang Dan Rimpang Pada Tanaman Wualae (Etlingera Elatior (Jack) R.M Smith): Antioxidant Activity of Ethanol Extract of Fruits, Leaves, Stems and Rhizome of Wualae (Etlingera Elatior (Jack) R.M Smith)

Wualae (Etlingera elatior (Jack) R.M Smith) is one of the plants in the Zingiberaceae family, widely used in medicine ranging from rhizomes, fruits, and flowers. Empirically Wualae are usually used by people for treating skin diseases, flavoring food, a natural soap, and in Southeast Sulawesi, it is used to treat typhoid fever. This study aims to examine the antioxidant activity of Wualae (Etlingera elatior) plant. The plant extracts were extracted by maceration method, antioxidant activity test was performed by 2,2-Diphenyl-1-picrylhydrazyl (DPPH) method. The results showed that ethanol extracts of fruits, leaves, stems and rhizomes of Wualae (Etlingera elatior) has the potential antioxidant activity with the IC50 values of 72.518 mg/L, 99.890 mg/L, 52.345 mg/L and 58.638 mg/L, respectively. and Vitamin C has IC50 value of 3,787 mg/L

Petrogenesis of Rinjani Post-1257-Caldera-Forming-Eruption Lava Flows

DOI:10.17014/ijog.3.2.107-126After the catastrophic 1257 caldera-forming eruption, a new chapter of Old Rinjani volcanic activity beganwith the appearance of Rombongan and Barujari Volcanoes within the caldera. However, no published petrogeneticstudy focuses mainly on these products. The Rombongan eruption in 1944 and Barujari eruptions in pre-1944, 1966,1994, 2004, and 2009 produced basaltic andesite pyroclastic materials and lava flows. A total of thirty-one sampleswere analyzed, including six samples for each period of eruption except from 2004 (only one sample). The sampleswere used for petrography, whole-rock geochemistry, and trace and rare earth element analyses. The Rombonganand Barujari lavas are composed of calc-alkaline and high K calc-alkaline porphyritic basaltic andesite. The magmashows narrow variation of SiO2 content that implies small changes during its generation. The magma that formedRombongan and Barujari lavas is island-arc alkaline basalt. Generally, data show that the rocks are enriched in LargeIon Lithophile Elements (LILE: K, Rb, Ba, Sr, and Ba) and depleted in High Field Strength Elements (HFSE: Y, Ti,and Nb) which are typically a suite from a subduction zone. The pattern shows a medium enrichment in Light REEand relatively depleted in Heavy REE. The processes are dominantly controlled by fractional crystallization andmagma mixing. All of the Barujari and Rombongan lavas would have been produced by the same source of magmawith little variation in composition caused by host rock filter process. New flux of magma would likely have occurredfrom pre-1944 until 2009 period that indicates slightly decrease and increase of SiO2 content. The Rombongan andBarujari lava generations show an arc magma differentiation trend

Lowering virus attack with improved yield and fiber quality in different cotton genotypes by early sown cotton (Gossypium hirsutum L.)

A three year study with the objective of exploring the possible role of different sowing dates and cotton genotypes on seed cotton yield, fiber quality and virus attack was conducted at the Cotton Research Station (CRS), Multan, Pakistan during three consecutive years (2006, 2007 and 2008). Two cotton genotypes namely: MNH-6070 and CIM-496 were sown on five different sowing dates (15th April, 1st May, 15th May, 1st June and 15th June) during the three consecutive years (2006, 2007 and 2008). The analyzed data indicated that early sown cotton (15th April) resulted in low virus attack (21.06%) and enhanced seed cotton yield (1575%), together with yield components (number of bolls per plant and boll weight), and improved fiber quality (staple length and micronaire) during all the three years as compared with late sown crop (15th June). Likewise, MNH-6070 also resulted in low virus attack (45.79%) and higher seed cotton yield (117.19%), as well as yield components. Regarding fiber quality, MNH-6070 resulted in higher micronarie, while CIM-496 resulted in higher staple length. Early sowing and cotton genotype MNH-6070 also resulted in maximum ginning out turn (GOT). Nonetheless, seed cotton yield and fiber quality were both negatively affected due to late sowing (1st and 15th of June) in both cotton genotypes. In crux, early sowing enhanced seed cotton yield due to increased number of bolls per plant, boll weight and low virus attack. Similarly, cotton genotype MNH-6070 also resulted to higher seed cotton yield, GOT and more resistance against virus attack due to its better genetic makeup. In summary, cotton genotype MNH-6070 should be sown on 15th April in order to obtain maximum seed cotton yield under agro-climatic conditions of Multan, Pakistan.Key words: Sowing time, seed cotton yield, staple length, micronaire

The FGF-21 genetic variants rs838133 and rs838145 are associated with high salt intake in the Emirati population

Food predilection is linked to variants in the hepatokine “Fibroblast Growth Factor-21” gene (FGF21); with rs838133 linked to the sweet tooth in Caucasians. The effect of FGF21 variants on food intake is still unclear in other populations. A cohort of 196 healthy Emirati subjects was investigated [age: 30.34 ± 9.75yrs (44.4% males)]. The FGF21 rs838133 and rs838145 were genotyped. The daily intake was calculated based on a 61-item food frequency questionnaire. Multivariate analysis was performed using in house R script that implements two-way unsupervised hierarchical clustering to detect the association of the studied single-nucleotide polymorphisms (SNPs) and related SNPs in linkage disequilibrium, using data from the 1000 genome project. Both SNPs were in Hardy-Weinberg Equilaribium (HWE). BMI positively correlated with age (p = 0.002), but not with caloric intake. Salt intake was significantly higher in subjects homozygous (A: rs838133) and (G:rs838145),(p = 0.03 and 0.01, respectively). An interaction was observed between both SNPs; significantly associated with high salt intake. Using publicly available data, both SNPs fall within a region transmitted in Iberians which has a profile closely similar to Caucasians, but far from Chinese population. In conclusion, the minor alleles of FGF21 rs838145 and rs838133 are associated with high salt intake in Emiratis and may suggest neuro-metabolic link to dietary preference across different populations

Whole-organism phenotypic screening methods used in early-phase anthelmintic drug discovery

Diseases caused by parasitic helminths (worms) represent a major global health burden in both humans and animals. As vaccines against helminths have yet to achieve a prominent role in worm control, anthelmintics are the primary tool to limit production losses and disease due to helminth infections in both human and veterinary medicine. However, the excessive and often uncontrolled use of these drugs has led to widespread anthelmintic resistance in these worms - particularly of animals - to almost all commercially available anthelmintics, severely compromising control. Thus, there is a major demand for the discovery and development of new classes of anthelmintics. A key component of the discovery process is screening libraries of compounds for anthelmintic activity. Given the need for, and major interest by the pharmaceutical industry in, novel anthelmintics, we considered it both timely and appropriate to re-examine screening methods used for anthelmintic discovery. Thus, we reviewed current literature (1977-2021) on whole-worm phenotypic screening assays developed and used in academic laboratories, with a particular focus on those employed to discover nematocides. This review reveals that at least 50 distinct phenotypic assays with low-, medium- or high-throughput capacity were developed over this period, with more recently developed methods being quantitative, semi-automated and higher throughput. The main features assessed or measured in these assays include worm motility, growth/development, morphological changes, viability/lethality, pharyngeal pumping, egg hatching, larval migration, CO2- or ATP-production and/or enzyme activity. Recent progress in assay development has led to the routine application of practical, cost-effective, medium- to high-throughput whole-worm screening assays in academic or public-private partnership (PPP) contexts, and major potential for novel high-content, high-throughput platforms in the near future. Complementing this progress are major advances in the molecular data sciences, computational biology and informatics, which are likely to further enable and accelerate anthelmintic drug discovery and development

Dynamic Clustering and Management of Mobile Wireless Sensor Networks

In Wireless Sensor Networks (WSNs), routing data towards the sink leads to unbalanced energy consumption among intermediate nodes resulting in high data loss rate. The use of multiple Mobile Data Collectors (MDCs) has been proposed in the literature to mitigate such problems. MDCs help to achieve uniform energy-consumption across the network, fill coverage gaps, and reduce end-to-end communication delays, amongst others. However, mechanisms to support MDCs such as location advertisement and route maintenance introduce significant overhead in terms of energy consumption and packet delays. In this paper, we propose a self-organizing and adaptive Dynamic Clustering (DCMDC) solution to maintain MDC-relay networks. This solution is based on dividing the network into well-delimited clusters called Service Zones (SZs). Localizing mobility management traffic to a SZ reduces signaling overhead, route setup delay and bandwidth utilization. Network clustering also helps to achieve scalability and load balancing. Smaller network clusters make buffer overflows and energy depletion less of a problem. These performance gains are expected to support achieving higher information completeness and availability as well as maximizing the network lifetime. Moreover, maintaining continuous connectivity between the MDC and sensor nodes increases information availability and validity. Performance experiments show that DCMDC outperforms its rival in the literature. Besides the improved quality of information, the proposed approach improves the packet delivery ratio by up to 10%, end-to-end delay by up to 15%, energy consumption by up to 53%, energy balancing by up to 51%, and prolongs the network lifetime by up to 53%

Quantum Tricritical Points in NbFe2_2

Quantum critical points (QCPs) emerge when a 2nd order phase transition is suppressed to zero temperature. In metals the quantum fluctuations at such a QCP can give rise to new phases including unconventional superconductivity. Whereas antiferromagnetic QCPs have been studied in considerable detail ferromagnetic (FM) QCPs are much harder to access. In almost all metals FM QCPs are avoided through either a change to 1st order transitions or through an intervening spin-density-wave (SDW) phase. Here, we study the prototype of the second case, NbFe$_2$. We demonstrate that the phase diagram can be modelled using a two-order-parameter theory in which the putative FM QCP is buried within a SDW phase. We establish the presence of quantum tricritical points (QTCPs) at which both the uniform and finite $q$ susceptibility diverge. The universal nature of our model suggests that such QTCPs arise naturally from the interplay between SDW and FM order and exist generally near a buried FM QCP of this type. Our results promote NbFe$_2$ as the first example of a QTCP, which has been proposed as a key concept in a range of narrow-band metals, including the prominent heavy-fermion compound YbRh$_2$Si$_2$.Comment: 21 pages including S

Antigenic Peptide Prediction From E6 and E7 Oncoproteins of HPV Types 16 and 18 for Therapeutic Vaccine Design Using Immunoinformatics and MD Simulation Analysis

Human papillomavirus (HPV) induced cervical cancer is the second most common cause of death, after breast cancer, in females. Three prophylactic vaccines by Merck Sharp & Dohme (MSD) and GlaxoSmithKline (GSK) have been confirmed to prevent high-risk HPV strains but these vaccines have been shown to be effective only in girls who have not been exposed to HPV previously. The constitutively expressed HPV oncoproteins E6 and E7 are usually used as target antigens for HPV therapeutic vaccines. These early (E) proteins are involved, for example, in maintaining the malignant phenotype of the cells. In this study, we predicted antigenic peptides of HPV types 16 and 18, encoded by E6 and E7 genes, using an immunoinformatics approach. To further evaluate the immunogenic potential of the predicted peptides, we studied their ability to bind to class I major histocompatibility complex (MHC-I) molecules in a computational docking study that was supported by molecular dynamics (MD) simulations and estimation of the free energies of binding of the peptides at the MHC-I binding cleft. Some of the predicted peptides exhibited comparable binding free energies and/or pattern of binding to experimentally verified MHC-I-binding epitopes that we used as references in MD simulations. Such peptides with good predicted affinity may serve as candidate epitopes for the development of therapeutic HPV peptide vaccines

Persistence and Effectiveness of Non-Biologic Systemic Therapies for Moderate-Severe Psoriasis in Adults: a Systematic Review

BACKGROUND: The persistence and effectiveness of systemic therapies for moderate-to-severe psoriasis in current clinical practice are poorly characterized. OBJECTIVES: To systematically review observational studies investigating the persistence and effectiveness of acitretin, ciclosporin, fumaric acid esters (FAE) and methotrexate, involving at least 100 adult patients with moderate-to-severe psoriasis, exposed to therapy for ≥ 3 months. METHODS: MEDLINE, Embase, the Cochrane Library and PubMed were searched from 1 January 2007 to 1 November 2017 for observational studies reporting on persistence (therapy duration or the proportion of patients discontinuing therapy during follow-up) or effectiveness [improvements in Psoriasis Area and Severity Index (PASI) or Physician's Global Assessment (PGA)]. This review was registered with PROSPERO, number CRD42018099771. RESULTS: Of 411 identified studies, eight involving 4624 patients with psoriasis were included. Variations in the definitions and analyses of persistence and effectiveness outcomes prevented a meta-analysis from being conducted. One prospective multicentre study reported drug survival probabilities of 23% (ciclosporin), 42% (acitretin) and 50% (methotrexate) at 1 year. Effectiveness outcomes were not reported for either acitretin or ciclosporin. The persistence and effectiveness of FAE and methotrexate were better characterized, but mean discontinuation times ranged from 28 to 50 months for FAE and 7·7 to 22·3 months for methotrexate. At 12 months of follow-up, three studies reported that 76% (FAE), 53% (methotrexate) and 59% (methotrexate) of patients achieved ≥ 75% reduction in PASI, and one reported that 76% of FAE-exposed patients achieved a markedly improved or clear PGA. CONCLUSIONS: The comparative persistence and effectiveness of acitretin, ciclosporin, FAE and methotrexate in real-world clinical practice in the past decade cannot be well described due to the inconsistency of the methods used