Association of time to prostate-specific antigen nadir and logarithm of prostate-specific antigen velocity after progression in metastatic prostate cancer with prior primary androgen deprivation therapy

published_or_final_versio

Antimicrobial resistance among uropathogens that cause acute uncomplicated cystitis in women in Hong Kong: a prospective multicenter study in 2006 to 2008

A prospective multicenter study was conducted to assess the epidemiology of antimicrobial resistance among uropathogens causing uncomplicated cystitis. Adult women with clinical diagnosis of uncomplicated cystitis were enrolled from 54 participating centers distributed all over Hong Kong during 2006 to 2008. A positive urine culture was found in 59.5% (352/592) patients. The patients had mean age of 44.9 years, and most (89.2%) were otherwise healthy. The most prevalent causative organism was Escherichia coli (77%), followed by other Enterobacteriaceae (14.2%), staphylococci (5.1%), and other Gram-positive bacteria (3.7%). The resistance rates of E. coli to co-trimoxazole and ciprofloxacin were 29.5% and 12.9%, respectively, and 14 isolates (5.2%) were confirmed as extended-spectrum β-lactamase (ESBL) producers. Of the ESBL producers, molecular studies showed CTX-M-14, CTX-M-24, or CTX-M-9. Nitrofurantoin and fosfomycin were active against >90% of the isolates, regardless of resistance phenotypes for other drugs. Pulsed-field gel electrophoresis of representative isolates showed that the antibiotic-resistant strains were genetically diverse. Patients with history of recent antibiotic use were significantly more likely to have infection by E. coli with co-trimoxazole resistance (odds ratio [OR], 2.8; 95% confidence interval [CI], 1.4-5.7; P = 0.003) and ciprofloxacin resistance (OR, 2.5; 95% CI, 1.1-5.8; P = 0.03). Knowledge of the resistance data and risk factors could inform better use of antibiotics for empiric therapy for acute uncomplicated cystitis. © 2010 Elsevier Inc. All rights reserved.link_to_subscribed_fulltex

Usefulness of magnetic resonance imaging volume-adjusted serum prostate-specific antigen in predicting pathological outcome of prostate cancer

Poster Presentation10th World Chinese Urological Society (WCUS) Meeting, 16 May 2015 NOMCC: 356-35

The optimal prostate-specific antigen and prostate-specific antigen density cut-off levels for Chinese men to consider transrectal ultrasound-guided prostate biopsy

Poster Presentation10th World Chinese Urological Society (WCUS) Meeting, 16 May 2015 NOMCC : 356-35

Incidence of thromboembolic and bleeding events in patients with newly diagnosed nonvalvular atrial fibrillation: An Asian multicenter retrospective cohort study in Singapore

Clinical Cardiolog

Risk factors for community-associated methicillin-resistant Staphylococcus aureus infection in Hong Kong

OBJECTIVES: The risk factors for community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infection were not well understood. The objective of this study was to identify risk factors associated with CA-MRSA infection in Hong Kong. METHODS: We carried out a matched case control study. Cases and controls were recruited from 14 acute public hospitals in Hong Kong. One control was individually matched to one case based on sex, age, admission date and ward location. We interviewed each case and control by telephone using a standard questionnaire. We used a conditional logistic regression model for multivariate analysis. RESULTS: We successfully recruited 127 pairs of matched case and control. We found that sharing of personal items with other persons had a higher risk of CA-MRSA infection (Adjusted matched odds ratio [aOR]: 4.71, 95% confidence interval [CI] 1.43-15.59). On the other hand, patients who had frequent hand washing practice (aOR: 0.21, 95%CI 0.06-0.72) and those who reported history of acne (aOR: 0.12, 95%CI 0.02-0.74) had a lower risk of CA-MRSA infection. CONCLUSIONS: We concluded that sharing of personal items with other persons is a risk factor for CA-MRSA infection while frequent hand washing is a protective factor against the infection.link_to_subscribed_fulltex

Effect of sequential kidney transplants from deceased donors on early graft function – an audit of the Hong Kong shared kidney program Hong Kong West Cluster arm

Poster PresentationConference Theme: Improving Functional Outcomes and Quality of Life after Surger

Prognostic significance of time to prostate-specific antigen (PSA) nadir and its relationship to survival beyond time to PSA nadir for prostate cancer patients with bone metastases after primary androgen deprivation therapy

BACKGROUND: This study investigated the prognostic significance of time to the prostate-specific antigen nadir (TTPN) and its relationship to survival beyond TTPN in metastatic prostate cancer after primary androgen-deprivation therapy (ADT). METHODS: All metastatic prostate cancer patients treated with primary ADT from 2000 to 2009 were reviewed. The prognostic significance of TTPN in predicting progression-free survival (PFS) beyond TTPN and overall survival (OS) beyond TTPN was analyzed using the Cox regression model. The median PFS and OS were plotted against TTPN on a monthly interval. The PFS beyond TTPN and the OS beyond TTPN with reference to TTPN were calculated and presented. RESULTS: The study enrolled 419 patients with a median follow-up period of 38 months. The findings showed that TTPN was a significant prognostic indicator for both PFS beyond TTPN (hazard ratio [HR] 0.72, 95 % confidence interval [CI] 0.52-0.99, p = 0.04) and OS beyond TTPN (HR 0.65, 95 % CI 0.47-0.90, p = 0.01) according to Cox regression analyses. The relationship between TTPN and survival beyond TTPN consisted of three phases. In the first phase (17 months for PFS and >20 months for OS), the survival beyond TTPN increased exponentially with TTPN. CONCLUSIONS: In this study, TTPN was a good prognostic indicator for PFS beyond TTPN and OS beyond TTPN in metastatic prostate cancer cases after primary ADT. Different TTPNs had different implications for predicting survival beyond TTPN

Management of child abuse in Hong Kong: Results of a territory-wide interhospital prospective surveillance study

Objectives. To study suspected child abuse among children in hospital in terms of clinical characteristics and the outcome of multidisciplinary case conferences. Design. Prospective observational study. Setting. All public hospitals in Hong Kong with a paediatric department. Methods. Anonymous data were prospectively collected from July 1997 to June 1999 using a standard report form for each case of suspected child abuse. The characteristics of the incidents and factors influencing the conclusion at the multidisciplinary case conference were studied. Results. Data for 592 cases of suspected child abuse were evaluated. Two hundred and eighty-seven of the children were boys and 305 were girls. The mean age was 7.3 years (range, 0-16.7 years). Physical abuse, alone or in combination with other forms of maltreatment, accounted for 277 (86.6%) of the 320 substantiated cases. Either, or both, biological parents comprised 71.3% of the perpetrators. Seven (1.2%) children died. Of the 540 children about whom a multidisciplinary case conference was held, abuse was established for 281 (52.0%) children. Abuse was more likely to be established if the victim had been known to a childcare agency (odds ratio=2.2; 95% confidence interval, 1.4-3.5), the abuse was not sexual (odds ratio=2.7; 95% confidence interval, 1.4-5.0), or if the child was seen at a hospital that handled more than 100 cases of suspected abuse during the study period (odds ratio=3.6; 95% confidence interval, 2.4-5.4). Conclusion. Child abuse identified in the hospital setting is predominantly physical in nature and death is not uncommon. Appraisal of suspected child abuse by multidisciplinary case conference appears to be influenced by the region of Hong Kong in which the case was handled.link_to_subscribed_fulltex