A Gaussian Bayesian model to identify spatio-temporal causalities for air pollution based on urban big data

Identifying the causalities for air pollutants and answering questions, such as, where do Beijing's air pollutants come from, are crucial to inform government decision-making. In this paper, we identify the spatio-temporal (ST) causalities among air pollutants at different locations by mining the urban big data. This is challenging for two reasons: 1) since air pollutants can be generated locally or dispersed from the neighborhood, we need to discover the causes in the ST space from many candidate locations with time efficiency; 2) the cause-and-effect relations between air pollutants are further affected by confounding variables like meteorology. To tackle these problems, we propose a coupled Gaussian Bayesian model with two components: 1) a Gaussian Bayesian Network (GBN) to represent the cause-and-effect relations among air pollutants, with an entropy-based algorithm to efficiently locate the causes in the ST space; 2) a coupled model that combines cause-and-effect relations with meteorology to better learn the parameters while eliminating the impact of confounding. The proposed model is verified using air quality and meteorological data from 52 cities over the period Jun 1st 2013 to May 1st 2015. Results show superiority of our model beyond baseline causality learning methods, in both time efficiency and prediction accuracy. © 2016 IEEE.postprintLink_to_subscribed_fulltex

Weaker land–climate feedbacks from nutrient uptake during photosynthesis-inactive periods

Terrestrial carbon–climate feedbacks depend on two large and opposing fluxes—soil organic matter decomposition and photosynthesis—that are tightly regulated by nutrients . Earth system models (ESMs) participating in the Coupled Model Intercomparison Project Phase 5 represented nutrient dynamics poorly , rendering predictions of twenty-first century carbon–climate feedbacks highly uncertain. Here, we use a new land model to quantify the effects of observed plant nutrient uptake mechanisms missing in most other ESMs. In particular, we estimate the global role of root nutrient competition with microbes and abiotic processes during periods without photosynthesis. Nitrogen and phosphorus uptake during these periods account for 45 and 43%, respectively, of annual uptake, with large latitudinal variation. Globally, night-time nutrient uptake dominates this signal. Simulations show that ignoring this plant uptake, as is done when applying an instantaneous relative demand approach, leads to large positive biases in annual nitrogen leaching (96%) and N O emissions (44%). This N O emission bias has a GWP equivalent of ~2.4 PgCO yr , which is substantial compared to the current terrestrial CO sink. Such large biases will lead to predictions of overly open terrestrial nutrient cycles and lower carbon sequestration capacity. Both factors imply over-prediction of positive terrestrial feedbacks with climate in current ESMs. 1,2 1,3 −1 2 2 2

Penetration Enhancement Effect of Turpentine Oil on Transdermal Film of Ketorolac

Purpose: To prepare transdermal films of ketorolac tromethamine (KT) and study the effect of turpentine oil as a penetration enhancer for the drug.Methods: Transdermal films of KT were prepared with Carbopol-934 and ethyl cellulose, with turpentine oil as the penetration enhancer, using solvent evaporation method. The films were characterized for physicochemical properties, ex vivo permeation, as well as in vivo anti-inflammatory and analgesic activities in Wistar rats. Results: The transdermal films were uniform in weight and thickness, flat, with high drug content (93.9 to 98.5 %) and of high folding endurance (134.0 to 180.0). Drug permeation through excised rat abdominal skin was prolonged, with the total drug release ranging from 58.88 to 88.98 % in 24 h. The films containing penetration enhancer showed higher drug permeation than the one without the enhancer; furthermore, drug permeation increased with increase in the concentration of the enhancer. The films were non-irritant to the skin. The transdermal films prepared with permeation enhancers showed greater anti-inflammatory activity (87.55 ± 2.50 and 83.24 ± 2.29 % inhibition of rat paw edema at the end of 12 h for formulations F2 and F3, respectively, compared to that of the formulation without enhancer with 69.99 %) as well as greater analgesic activity (quicker onset of analgesia in 1.5 h with longer duration of 10 to 12 h).Conclusion: Transdermal films of ketorolac have a potential for use in the treatment of pain andinflammation. Incorporation of turpentine oil in the films enhances not only drug flux but also analgesic and anti-inflammatory activities in rats

Triple-Mode Cavity Bandpass Filter on Doublet with Controllable Transmission Zeros

© 2013 IEEE. On the basis of doublet and its properties, a class of multiple-mode narrow band bandpasss filter is designed and fabricated by simultaneously exploiting the three resonant modes in a single rectangular cavity: TE101, TE011, and TM110 modes. The input/output ports of the proposed filter are fed by coupling a microstrip line to a slot on the side wall of a rectangular cavity. Different modes are excited by changing the position and shape of the two slots at input and output of the rectangular cavity without any intra-cavity coupling. Besides three poles within the passband, a pair of transmission zeros (TZs) is achieved, which can be controlled independently by setting the positions of the two TZs at the lower and/or upper stopband. High stopband attenuation and high filtering selectivity are achieved by considerably allocating three transmission poles and two zeros. In order to verify the proposed theory, two filter prototypes are fabricated and measured

Individually Frequency Tunable Dual- and Triple-band Filters in a Single Cavity

© 2013 IEEE. This paper presents a new class of second-order individually and continuously tunable dual- and triple-band bandpass filters in a single metal cavity. Each passband is realized by two identical metal posts. These dual- and triple-band tunable filters are achieved by putting two or three identical sets of metal-post pair in a single metal cavity. Metal screws are co-designed as a part of the metal posts to control their insertion depth inside the cavity. In this way, the resonant frequencies can be continuously controlled and designed at the desired frequency bands. Moreover, the distance between the two metal posts in a post pair can be freely tuned. Thus, the external quality factor (Qe) and coupling coefficient (k) between the adjacent modes can be easily adjusted to meet the specified requirement in synthesis design. At the bottom of the cavity, some grooves are used to extend the tunable frequency range and make the resonant frequency linearly varied with the height of the metal post. The center frequency of each passband can be independently tuned with a frequency range of 0.8-3.2 GHz and tunable ratio of 4. Finally, the continuously tunable dual- and triple-band bandpass filters prototypes with second order response are designed and fabricated, of which each passband can be individually tuned with a large tuning range

Wideband Filtering Out-of-Phase Power Dividers Using Slotline Resonators and Microstrip-to-Slotline Transitions

© 2019 IEEE. Two wideband filtering out-of-phase power dividers are designed and analyzed. The initial design is composed of a quarter-wavelength slotline resonator and two microstrip-to-slotline transitions. Three transmission poles are produced to form the passband. Excellent matching and isolation are achieved using extra matching network. Based on the initial design, a pair of stepped-impedance open stubs are shunted at the output ports to improve the passband selectivity. The designs have been verified through experiment. The tested results show that the proposed devices have achieved 60% operating bandwidth, 1.8 dB insertion loss, 1.2° phase error and excellent in-band matching and isolation

Histamine increases neuronal excitability and sensitivity of the lateral vestibular nucleus and promotes motor behaviors via HCN channel coupled to H2 receptor

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Podoplanin-positive cancer cells at the edge of esophageal squamous cell carcinomas are involved in invasion

Podoplanin (PDPN) is a well established lymphatic endothelial marker and has frequently been observed in cancer cells at the edge of cancer masses. Previous studies investigating the association between PDPN expression and patient prognosis have had contradictory results. In the present study, it was hypothesized that the different locations of PDPNpositive cells may explain these varying results. The present study aimed to focus on PDPN expression at the edge of esophageal cancer cell nests. In order to analyze the clinical significance of this PDPN expression, immunohistochemistry was performed using esophageal cancer tissue microarrays. PDPN expression at the edge of the cancer cell nest was found to be significantly associated with invasion (P<0.05) and poor prognosis (P<0.001) in patients with cancer. To further investigate the role of PDPN expression in cancer cells, the PDPN gene was cloned and transfected into esophageal squamous cell carcinoma (ESCC) cell lines. PDPN expression was also knocked down using small interfering RNA. PDPNpositive cancer cells were found to exhibit invasion characteristics. Thus, PDPN expression at the edge of a cancer cell nest may indicate invasion and represent a poor prognostic factor for ESCCs.published_or_final_versio

Coating for fabrics with nano tube-panis and the properties of conducting and shielding microwave

2005-2006 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe