Twenty years of technology and strategic roadmapping research: A school of thought perspective

© 2020 Two decades ago the thirtieth-anniversary special issue of Technological Forecasting and Social Change correctly anticipated the widespread adoption of technology and strategic roadmapping at firm, sectoral and national levels. In this article, we explore the evolution of roadmapping studies since that time. Drawing on a mixed-methods approach (i.e. topic modelling, genealogical analysis, content analysis and interviews), we reveal the development of seven distinctive ‘schools of thought’: the Cambridge practical school, the Seoul school, the Portland and Bangkok schools, the Cambridge phenomenological school, the Beijing school and the Moscow school. We show that the schools differ in terms of (a) the research orientation, whether it be solution- or theory-oriented; (b) the research methods and data sources being used; and (c) the nature of contributions that each school seeks to achieve. The different areas of emphasis associated with each school are not competing but complementary, and together they develop the eclectic body of knowledge on roadmapping

Mediating and catalysing innovation: A framework for anticipating the standardisation needs of emerging technologies

The development of technology strategies are often supported by strategic frameworks. Although standards can be critical in fostering technological innovation, particularly by supporting knowledge diffusion, their importance is often neglected by commonly used strategic frameworks. This paper presents a framework which uses the knowledge that needs to transition between key anticipated innovation activities to anticipate potential standardisation needs for emerging technologies. The framework draws attention to strategic considerations and dimensions that might otherwise be overlooked, including different types of standards; standardisation stakeholders; the alignment, coordination, and sequencing of standards; and how these all change over time. A technology roadmapping based framework was used because it explicitly characterises the alignment, coordination, and sequencing of innovation activities (over time) and can be configured to draw out information against the other above strategic considerations and dimensions. The principles and utility of the framework are demonstrated in three contrasting case studies: synthetic biology, additive manufacturing, and smart grid. These show how standards mediate between innovation actors by codifying and diffusing knowledge and can enhance and catalyse innovation. The proposed framework can be used to reveal where standards might be used to support innovation, better characterise the types of standards needed, identify the stakeholders needed to develop them, and highlight any potential alignment, coordination, and sequencing issues related to standardisation activities.Thanks are due to colleagues in BIS, BSI, TSB and Innovate UK for insights, useful conversations and advice on technological domains, and to BIS, BSI and The Gatsby Charitable Foundation, United Kingdom (GA3230) for their financial support. Thanks also due to two anonymous reviewers who helped to refine and more clearly articulate the messages in the article.This is the author accepted manuscript. The final version is available from Elsevier via http://dx.doi.org/10.1016/j.technovation.2015.11.00

Deletions within the azoospermia factor subregions of the Y chromosome in Hong Kong Chinese men with severe male-factor infertility: controlled clinical study.

OBJECTIVE: To determine the patterns and the prevalence of microdeletions in the azoospermia factor subregions of the Y chromosome in Hong Kong Chinese men with severe male-factor infertility. DESIGN: Controlled clinical study. SETTING: Reproductive centre of a university teaching hospital, Hong Kong. PARTICIPANTS: Fifty-eight men with severe male-factor infertility who participated in the in vitro fertilisation programme from May 1998 through March 1999, and 46 male volunteers with proven fertility. MAIN OUTCOME MEASURES: Polymerase chain reaction analysis of DNA from peripheral blood lymphocytes using six loci spanning the AZFa, AZFb, and AZFc subregions of the Y chromosome. RESULTS. No microdeletions were detected in the fertile controls or in patients with obstructive azoospermia. Deletions within the AZFc subregion were found in 9% (4/44) of men with non-obstructive azoospermia or severe oligospermia. Neither AZFa nor AZFb deletions were detected in any participants. CONCLUSION: Deletions within the azoospermia factor subregions of the Y chromosome are associated with severe male-factor infertility in Hong Kong Chinese men.published_or_final_versio

Prevalence and awareness of lower urinary tract symptoms among males in the Outpatient Clinics of Universiti Kebangsaan Malaysia Medical Centre.

This study aims to determine the prevalence of lower urinary tract symptoms (LUTS) and level of awareness among male outpatients in Universiti Kebangsaan Malaysia Medical Centre (UKMMC). A questionnaire consisting of demographic data, questions related to knowledge, attitude and practice on BPH and the International Prostate Symptom Score (IPSS) was used for this study. Uroflowmetry and bladder scan were used to evaluate the function of the urinary tract and severity of BPH. Urine dipstick was done for glycosuria, proteinuria and haematuria. A total of 220 respondents were surveyed. The prevalence of moderately and severely symptomatic LUTS was 42.7%. The most commonly reported LUTS were nocturia (78.2%), frequency (58.2%) and incomplete emptying (44.6%). The prevalence of glycosuria, proteinuria and haematuria were 23.6%, 11.4% and 1.8% respectively. There was a significant association between increasing age with the severity of LUTS (p=0.005). Out of 102 respondents with voided urine volume greater than 150 mL, there was a significant decrease in maximum (Qmax) (p=0.039) and average (Qave) urine flow rates with every 10 years increase of age (p=0.001). The majority of respondents (59.5%) have heard of BPH before. Over 78.2% of the respondents would seek medical attention if they have LUTS with 15.9% saying they would seek traditional treatment. In conclusion, the prevalence of LUTS was high and the level of awareness was satisfactory

Reaching out to the poorest of the poor - a 4-week outreach programme at the Missionaries of Charity : a pilot outreach service programme to enable professionalism development in medical students

Poster Presentation: no. PP21Conference Theme: Learner Wellbeing Across the ContinuumINTRODUCTION: Service learning allows medical students to integrate course material with meaningful community services, which in turn enriches their learning experience and social responsibility. This study explored attitudes towards service learning of medical students who participated in a 4-week elective attachment to a shelter home in Hong Kong …published_or_final_versio

Association of EP2 receptor and SLC19A3 in regulating breast cancer metastasis

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Bidirectional signaling of neuregulin-2 mediates formation of GABAergic synapses and maturation of glutamatergic synapses in newborn granule cells of postnatal hippocampus

Expression of neuregulin-2 (NRG2) is intense in a few regions of the adult brain where neurogenesis persists; however, little is understood about its role in developments of newborn neurons. To study the role of NRG2 in synaptogenesis at different developmental stages, newborn granule cells in rat hippocampal slice cultures were labeled with retrovirus encoding tetracycline-inducible microRNA targeting NRG2 and treated with doxycycline (Dox) at the fourth or seventh postinfection day (dpi). The developmental increase of GABAergic postsynaptic currents (GPSCs) was suppressed by the early Dox treatment (4 dpi), but not by late treatment (7 dpi). The late Dox treatment was used to study the effect of NRG2 depletion specific to excitatory synaptogenesis. The Dox effect on EPSCs emerged 4 d after the impairment in dendritic outgrowth became evident (10 dpi). Notably, Dox treatment abolished the developmental increases of AMPA-receptor mediated EPSCs and the AMPA/NMDA ratio, indicating impaired maturation of glutamatergic synapses. In contrast to GPSCs, Dox effects on EPSCs and dendritic growth were independent of ErbB4 and rescued by concurrent overexpression of NRG2 intracellular domain. These results suggest that forward signaling of NRG2 mediates GABAergic synaptogenesis and its reverse signaling contributes to dendritic outgrowth and maturation of glutamatergic synapses.117Ysciescopu

Targeting quiescent leukemic stem cells using second generation autophagy inhibitors

In chronic myeloid leukemia (CML), tyrosine kinase inhibitor (TKI) treatment induces autophagy that promotes survival and TKI-resistance in leukemic stem cells (LSCs). In clinical studies hydroxychloroquine (HCQ), the only clinically approved autophagy inhibitor, does not consistently inhibit autophagy in cancer patients, so more potent autophagy inhibitors are needed. We generated a murine model of CML in which autophagic flux can be measured in bone marrow-located LSCs. In parallel, we use cell division tracing, phenotyping of primary CML cells, and a robust xenotransplantation model of human CML, to investigate the effect of Lys05, a highly potent lysosomotropic agent, and PIK-III, a selective inhibitor of VPS34, on the survival and function of LSCs. We demonstrate that long-term haematopoietic stem cells (LT-HSCs: Lin−Sca-1+c-kit+CD48−CD150+) isolated from leukemic mice have higher basal autophagy levels compared with non-leukemic LT-HSCs and more mature leukemic cells. Additionally, we present that while HCQ is ineffective, Lys05-mediated autophagy inhibition reduces LSCs quiescence and drives myeloid cell expansion. Furthermore, Lys05 and PIK-III reduced the number of primary CML LSCs and target xenografted LSCs when used in combination with TKI treatment, providing a strong rationale for clinical use of second generation autophagy inhibitors as a novel treatment for CML patients with LSC persistence

Plasma high sensitivity troponin T levels in adult survivors of childhood leukaemias: determinants and associations with cardiac function

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Spatially-resolved electronic and vibronic properties of single diamondoid molecules

Diamondoids are a unique form of carbon nanostructure best described as hydrogen-terminated diamond molecules. Their diamond-cage structures and tetrahedral sp3 hybrid bonding create new possibilities for tuning electronic band gaps, optical properties, thermal transport, and mechanical strength at the nanoscale. The recently-discovered higher diamondoids (each containing more than three diamond cells) have thus generated much excitement in regards to their potential versatility as nanoscale devices. Despite this excitement, however, very little is known about the properties of isolated diamondoids on metal surfaces, a very relevant system for molecular electronics. Here we report the first molecular scale study of individual tetramantane diamondoids on Au(111) using scanning tunneling microscopy and spectroscopy. We find that both the diamondoid electronic structure and electron-vibrational coupling exhibit unique spatial distributions characterized by pronounced line nodes across the molecular surfaces. Ab-initio pseudopotential density functional calculations reveal that the observed dominant electronic and vibronic properties of diamondoids are determined by surface hydrogen terminations, a feature having important implications for designing diamondoid-based molecular devices.Comment: 16 pages, 4 figures. to appear in Nature Material