Cellular therapies for treating pain associated with spinal cord injury

Spinal cord injury leads to immense disability and loss of quality of life in human with no satisfactory clinical cure. Cell-based or cell-related therapies have emerged as promising therapeutic potentials both in regeneration of spinal cord and mitigation of neuropathic pain due to spinal cord injury. This article reviews the various options and their latest developments with an update on their therapeutic potentials and clinical trialing

Developing a Model of Associations Between Chronic Pain, Depressive Mood, Chronic Fatigue, and Self-Efficacy in People With Spinal Cord Injury

Chronic pain, chronic fatigue, and depressive mood are prevalent conditions in people with spinal cord injury (SCI). The objective of this research was to investigate the relationship between these conditions in adults with SCI. Multivariate analysis o

Increasing Australian-Indonesian monsoon rainfall linked to early Holocene sea-level rise

The Australian–Indonesian summer monsoon affects rainfall variability and hence terrestrial productivity in the densely populated tropical Indo–Pacific region. It has been proposed that the main control of summer monsoon precipitation on millennial timescales is local insolation, but unravelling the mechanisms that have influenced monsoon variability and teleconnections has proven difficult, owing to the lack of high-resolution records of past monsoon behaviour. Here we present a precisely dated reconstruction of monsoon rainfall over the past 12,000 years, based on oxygen isotope measurements from two stalagmites collected in southeast Indonesia. We show that the summer monsoon precipitation increased during the Younger Dryas cooling event, when Atlantic meridional overturning circulation was relatively weak. Monsoon precipitation intensified even more rapidly from 11,000 to 7,000 years ago, when the Indonesian continental shelf was flooded by global sea-level rise. We suggest that the intensification during the Younger Dryas cooling was caused by enhanced winter monsoon outflow from Asia and a related southward migration of the intertropical convergence zone. However, the early Holocene intensification of monsoon precipitation was driven by sea-level rise, which increased the supply of moisture to the Indonesian archipelago