17 research outputs found
Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases
- Author
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- The Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group
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- ZZ Chong
- Publication venue
- Publication date
- 09/08/2008
- Field of study
The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular "reactive oxygen species" (ROSs)
can exhibit a number of biological effects, they are not of themselves
excessively reactive and thus they are not especially damaging at physiological
concentrations. However, their reactions with poorly liganded iron species can
lead to the catalytic production of the very reactive and dangerous hydroxyl
radical, which is exceptionally damaging, and a major cause of chronic
inflammation. We review the considerable and wide-ranging evidence for the
involvement of this combination of (su)peroxide and poorly liganded iron in a
large number of physiological and indeed pathological processes and
inflammatory disorders, especially those involving the progressive degradation
of cellular and organismal performance. These diseases share a great many
similarities and thus might be considered to have a common cause (i.e.
iron-catalysed free radical and especially hydroxyl radical generation). The
studies reviewed include those focused on a series of cardiovascular, metabolic
and neurological diseases, where iron can be found at the sites of plaques and
lesions, as well as studies showing the significance of iron to aging and
longevity. The effective chelation of iron by natural or synthetic ligands is
thus of major physiological (and potentially therapeutic) importance. As
systems properties, we need to recognise that physiological observables have
multiple molecular causes, and studying them in isolation leads to inconsistent
patterns of apparent causality when it is the simultaneous combination of
multiple factors that is responsible. This explains, for instance, the
decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference
Hiatal Hernia Repair by Restoration and Stabilization of Normal Anatomy An Evaluation in Four Dogs and One Cat
- Author
- Alexander JW
- Alibibi R.
- Allison PR.
- Baue AE
- Castell D.
- Dhein CRM
- Dodds WJ
- Eliska O.
- Ellis FH
- Ellison GW
- Frye FL.
- Gaskell CJ
- Harvey CE
- Henderson RD
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- Higgs RH
- Iwasaki M.
- Jamieson GG
- Kluth GA
- Meester TR
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- Parks JL
- Patrikios J.
- Payne WS
- Peterson SL.
- Pope CE.
- Richter JE
- Robotham GR.
- Rogers WA
- Teunissen GHB
- Woodward ER.
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Acute Renal Failure in the ITU: The Nephrologist’s View
- Author
- A Baue
- A Heidland
- AN Minuth
- B Jennett
- C Giordano
- C Pru
- CH Espinel
- CP Stoutenbeek
- D Bihari
- DE Butkus
- DE Fry
- EA Elebute
- F Epstein
- F Liano
- HH Rasmussen
- HL Corwin
- IMA Ledingham
- J Lien
- J-D Baumgartner
- JH Silas
- JI Shapiro
- JM Boulton-Jones
- JR Gall Le
- JS Cameron
- JS Cameron
- JS Cameron
- JW Lohr
- M Ball
- M Hilberman
- M Smithies
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- MAB Thomas
- ML Bullock
- N Wardle
- P Noone
- RG Bunney
- RJ Anderson
- RW Pine
- RWS Chang
- S Lemeshow
- SL Milligan
- WA Knaus
- WA Knaus
- WG Cioffi
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1990
- Field of study
Endogenous endotoxemia of intestinal origin during cardiopulmonary bypass
- Author
- A. E. Martinez-Pellús
- AE Baue
- AE Martinez-Pellüs
- BO Meyrick
- CP Stoutenbeek
- DA Rocke
- DW Riddington
- E Abraham
- EA Deitch
- EJ Ziegler
- G. Seller
- HM Oudemans-van Straaten
- HR Michie
- J. Canovas
- J. Moro
- J. Sapiña
- JJM Saene Van
- JM Browin
- JW Alexander
- KM Taylor
- LG Thijs
- LM Andersen
- LM Colleti
- LW Andersen
- M Basha
- M. Bru
- MA Fox
- MM Camp De
- MR Pinsky
- P. Merino
- RG Fiddian-Green
- RL Danner
- SDD trialist collaborative group
- SK Ohri
- SO Heard
- T. Fuentes
- WF Casey
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Involvement of Bacteria/Endotoxin Translocation in the Development of Multiple Organ Failure
- Author
- A Ayala
- A Ayala
- A Cabie
- A Peitzman
- A Petros
- AE Baue
- AG Plaut
- AM Munster
- B Zingarelli
- BFJ Rush
- BFJ Rush
- BFJ Rush
- C Thiemermann
- CEM Brathwaite
- CJ Cahill
- CJ Carrico
- CM Ryan
- CP Stoutenbeek
- D Nitsche
- D Payne
- DC Savage
- DE Fry
- DJ Burke
- DL Topping
- DT Garidis
- DW Wilmore
- E Faist
- EA Carter
- EA Deitch
- EA Deitch
- EA Deitch
- EA Deitch
- EA Deitch
- EA Deitch
- EA Deitch
- EA Deitch
- EA Deitch
- EA Deitch
- EA Deitch
- EA Deitch
- EA Deitch
- EA Deitch
- EA Deitch
- F Moore
- FE Padova Di
- G Scannell
- G Schlag
- G Schlag
- G Schlag
- G Spaeth
- H Gans
- H Liehr
- H Redl
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- HC Polk
- HM Dijkstra
- I Marzi
- IH Chaudry
- IH Chaudry
- J Fine
- JC Marshall
- JM Hammond
- JM Koziol
- JW Alexander
- JW Alexander
- JW Alexander
- JW Baker
- JX Jiang
- K Maejima
- L Bertok
- M Machnicki
- M Marzi
- MG Caty
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- MK Donohoe
- N Cruz
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- P Rhee
- PAM Leeuwen Van
- PJ Sanderson
- R Foulkes
- R Shenkar
- R Tokyay
- RA Winchurch
- RJ Goris
- RM Roumen
- RN Garrison
- S Bahrami
- S Bahrami
- S Bahrami
- S Endo
- S Stylianos
- SE Morris
- SR Zapata
- ST Zeigler
- TB Tomasi
- TR Ziegler
- U Haglund
- W Ertel
- W Ertel
- WG Jones
- WG Jones
- WR Culbertson
- Y Haskel
- Y Yao
- Y Yao
- YM Yao
- YM Yao
- YM Yao
- ZY Sheng
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1996
- Field of study
Die Therapie der Sepsis
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- A Bernstein
- A Cerami
- AD Mason
- AE Baue
- AE Baue
- B Eiseman
- B Schlüter
- B Schlüter
- B Wagenknecht
- BE Kreger
- BG MacMillan
- CJ Carrico
- CL Sprung
- CL Sprung
- CL Sprung
- CP Stouenbeek
- DA Jordan
- DE Fry
- E Abraham
- E Erdmann
- E Faist
- E Moyer
- EA Deitch
- EJ Ziegler
- EN Wardle
- FB Cerra
- FD Daschner
- FD Daschner
- G Germann
- G Gutierrez
- G Pilz
- GD Martich
- GE Vogel
- GHA Clowes
- H Neuhof
- H Redl
- H Schottmüller
- H Yuesheng
- HF Carvajal
- HJ Gramm
- HP Schuster
- HP Schuster
- I Schedel
- JA Goris
- JA Weigel
- JC Marshall
- JD Baumgartner
- JE Parillo
- JF Hesselvik
- JJ Zimmermann
- JKS Nuytinck
- JM Watters
- JN Sheagren
- JO Basadre
- JR Border
- JW Holaday
- K Byrne
- K MeBmer
- K Reinhart
- K Schultze-Osthoff
- K Waxman
- KJ Gorelick
- M Hersh
- M Jochum
- M Köller
- MC Vespasiano
- MM DeCamp
- MM Parker
- MP Fink
- MS Cain
- MT Haupt
- NI Wedel
- PG Horgan
- PM Suter
- PQ Eickacker
- R Seitz
- R Stuttmann
- R Stuttmann
- RC Bone
- RC Bone
- RF Wilson
- RG Fiddian-Green
- RH Demling
- RJA Goris
- RJA Goris
- RL Danner
- RP Wenzel
- S Berg
- SM Ayres
- SM Cain
- SW Merrell
- T Mitsuo
- The Veterans Administration systemic sepsis cooperative study group
- TL Higgins
- U Bergmann
- U Hartenauer
- U Müller
- W Oettinger
- WA Knaus
- WC Shoemaker
- WC Shoemaker
- WC Shoemaker
- WG Marshall
- WJ Sibbald
- WJ Sibbald
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1993
- Field of study
Sialyltransferase and Neuraminidase Levels/Ratios and Sialic Acid Levels in Peripheral Blood B Cells Correlate with Measures of Disease Activity in Patients with Systemic Lupus Erythematosus and Rheumatoid Arthritis: A Pilot Study
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- A Lateef
- A Mondal
- AH Kao
- AH Lepers
- AW Barb
- B Stypiñsa
- C Castro-Villegas
- C Costa-Nogueira
- C Fabrizio
- CC Liu
- Che-ching Huang
- CS Crowson
- D Anand
- D Kidder
- DD Gladman
- E Klime
- G Picco
- GG ILLei
- J Jenner
- JC Crispín
- Jose Crispin
- JR Cutis
- JW Baue
- K Fuushima
- L Rajasehar
- LA Cerezo
- LB Liou
- LB Liou
- Lieh-bang Liou
- MB Jones
- MF Bakker
- MF Smith
- MF Smith
- MJ Podolska
- MLL Prevoo
- P Riboldi
- PA Videira
- RM Anthony
- S Lehoux
- SJ Van Dyken
- SR Greisen
- T Hennet
- T Pincus
- V Seyrantepe
- VR Naraparaju
- W Gorczyca
- XP Chen
- Y Kaneo
- Y Urata
- Y Wang
- YJ Ha
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
The Liver as Modulator of the Host-Defense Response: Host-Defense Failure Disease as a Manifestation of Hepatic Decompensation
- Author
- A DelMaschio
- A Koj
- A Yuo
- AE Baue
- AI Rivkind
- AL Goldberg
- AM Turnstall
- AP Kaplan
- AP Osmand
- B Beutler
- B Beutler
- B Turchen
- BA Baldo
- BF Rush
- BM Babior
- C Chiarla
- C Mold
- CA Dinarello
- CA Dinarello
- CA Dinarello
- CJ Horvath
- CM Dunham
- D Bernuau
- DE Staunton
- E Faist
- E Faist
- E Flores
- EA Newsholme
- FB Cerra
- FB Cerra
- FE Gump
- G Deby-Dupont
- G Goldman
- G Nanni
- G Sganga
- GHA Clowes Jr.
- GHA Clowes Jr.
- GJ Darlington
- H Baumann
- HKS Nuytinck
- HS Earp
- I Kushner
- I Kushner
- IM Goldstein
- J MacLouf
- JB Smith
- JC Smith
- JD McGarry
- JD Meyer
- JE Volanakis
- JH Siegel
- JH Siegel
- JH Siegel
- JH Siegel
- JH Siegel
- JJ Pomposelli
- JM Harlan
- JM Walters
- JW Crowell
- K James
- K Ohlsson
- LL Moldawer
- M Elia
- M Pittiruti
- M Pittiruti
- MA West
- ME Lanser
- MI Cybulsky
- MM Mayer
- NB Vedder
- P Braquet
- P Damas
- P Felig
- PG Canonico
- PO Hasselgren
- PO Hasselgren
- PZ Sobocinski
- R Rothlein
- RA Robey
- RB Johnson
- RD Curran
- RF Mortensen
- RF Mortensen
- RG Rupp
- RL Hoover
- RR Wolfe
- S Goldstein
- SE Dahlen
- SJ Weiss
- T Timonen
- TC Vary
- TC Vary
- TC Vary
- TC Vary
- TC Vary
- TE Hugli
- TF O’Donnell
- TJ Abernethy
- TJ Abernethy
- TM McIntyre
- VR Young
- WL Thompson
- WS Tillett
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1991
- Field of study
Sepsis, Disseminated Intravascular Coagulation and Multiorgan Failure: Catastrophic Events in Severe Burns
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- A Takeuchi
- AE Baue
- AN Neely
- AP Fishman
- B Fredholm
- BJ Pardy
- BM Wagner
- C Ahren
- C Teplitz
- C Teplitz
- CL Wells
- DA Parks
- DE Fry
- DJ Effeney
- DW Swank
- E Elias
- EA Deitch
- EA Deitch
- EA Deitch
- EA Deitch
- FP Ognibene
- FW Blaisdell
- G Bounous
- G Dupuytren
- G Kakis
- G Schlag
- G Yi-sheng
- GHA Clowes
- H Redl
- H Wolochow
- HA Linares
- HA Linares
- HB Hechtman
- HKS Nuytinck
- HS Jacob
- I Popiel
- J Delarue
- J Graf
- J Long
- J Marshall
- J Orth
- J Reichen
- JB Wiles
- JL Boyer
- JL Meakins
- JR Border
- JW Baker
- K Eurenius
- K Maejima
- L Arnold
- L Ma
- MJ Phillips
- MJ Phillips
- MJ Phillips
- MM DeCamp
- N Aikawa
- N Alkjaersig
- N Cano
- N Mohan
- NB Vedder
- P Olsson
- P Petroff
- PB Neame
- PJ Hamilton
- PM Henson
- PR Craddock
- PR Craddock
- PW Curreri
- R Berringer
- R Carmona
- RD Berg
- RD Berg
- RD Berg
- RH Bartlett
- RH Demling
- RH Demling
- RH Demling
- RH Demling
- RJA Goris
- RL Bick
- RM Hardaway
- RS Cotran
- RS Sprague
- RV Argamaso
- S Erlinger
- S Hosea
- S Inoue
- S Sevitt
- S Sevitt
- SM Karyoute
- T Hurd
- T Watanabe
- TJ Zimmerman
- TM Hyers
- TR Franson
- W Cumin
- WB Wartman
- WF McManus
- WJ Schirmer
- WW Ford
- Z Horakova
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1991
- Field of study
Shock States and Nitric Oxide
- Author
- A Billiau
- A Levitzki
- A Novogrodsky
- A Petros
- A Petros
- A Salzman
- A Vanichikin
- AB Groeneveld
- AE Baue
- AG Doyle
- AJ Wicken
- AK Nussler
- AM Leone
- AR Nogare
- AS Cross
- B Beutler
- C Estrada
- C Nathan
- C Szabo
- C Szabo
- C Thiemermann
- C Thiemermann
- C Thiemermann
- C Thiemermann
- CA Dinarello
- CA Schott
- CC Wu
- CC Wu
- CE Walder
- CE Wright
- CJ Fisher Jr
- CJ Fisher Jr
- CL Sprung
- D Dunn
- D Edelstein
- D Kunz
- D Paya
- D Watson
- DD Rees
- DS Fletcher
- E Abraham
- EA Deitsch
- EE Douzinas
- EP Garvey
- EP Garvey
- ET Rietschel
- F Stuber
- FM Robertson
- FP Heinzel
- G Julou-Schaeffer
- G Kwon
- G Nabel
- G Wakabayashi
- GA Joly
- GJ Southan
- GJ Southan
- H Ruetten
- H Ruetten
- H Ruetten
- H Ruetten
- H Ruetten
- HG Seo
- J Assreuy
- J Cohen
- J Hirahashi
- J Schilling
- JA Corbett
- JA Lorente
- JC Preiser
- JC Preiser
- JD Macmicking
- JE Parrillo
- JF Dhainaut
- JM Griscavage
- JPM Evans
- JW Lowenthal
- K Reinhart
- KJ Tracey
- KJ Tracey
- L Young
- LA Doughty
- LE Lambert
- M Kohno
- M Koide
- M Parker
- M Saura
- M Testa
- MA Marletta
- MJ Diaz-Guerra
- Morbidity and Mortality Weekly Report
- MP Sherman
- MS Arkovitz
- MW Radomski
- MW Radomski
- N Arima
- N Seiler
- P Ou
- PA Baeuerle
- PA Baeuerle
- PF Barnes
- PJ Barnes
- PJ Barnes
- PJ Shultz
- PL Feldman
- PL Feldman
- Q Xie
- Q Xie
- R Grover
- R Latini
- R Sen
- RC Sprong
- RG Kilbourn
- RM Mckenna
- RM Palmer
- RM Roumen
- S Grimm
- S Miyamoto
- S Moncada
- S Okusawa
- SC Sun
- SF Green
- SJ Kimpe
- SL Weinstein
- SM Morris Jr
- SM Morris Jr
- SM Opal
- SR Smith
- SS Gross
- T Bieganski
- T Henkel
- T Mozes
- T Nishiya
- T Saetre
- T Tetsuka
- T Yokoo
- TA Springer
- TM Mahon
- TR Billiar
- U Forstermann
- U Siebenlist
- UF Schade
- V Bulut
- V Imbert
- VB Schini
- WA Knaus
- WR Tracey
- XQ Wei
- Y Geng
- YC Lin
- Z Dong
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2000
- Field of study