15 research outputs found
Spectrums of Black Hole in de Sitter Spacetime with Highly Damped Quasinormal Modes: High Overtone Case
Motivated by recent physical interpretation on quasinormal modes presented by
Maggiore, the adiabatic quantity method given by Kunstatter is used to
calculate the spectrums of a non-extremal Schwarzschild de Sitter black hole in
this paper, as well as electrically charged case. According to highly damped
Konoplya and Zhidenko's numerical observational results for high overtone
modes\cite{Konoplya}, we found that the asymptotic non-flat spacetime structure
leads two interesting facts as followings: (i) near inner event horizon, the
area and entropy spectrums, which are given by ,
, are equally spaced accurately. (ii) However, near
outer cosmological horizon the spectrums, which are in the form of , , are not
markedly equidistant. Finally, we also discuss the electrically charged case
and find the black holes in de Sitter spacetime have similar quantization
behavior no matter with or without charge.Comment: 12 pages, 2 firures, published versio
Cardiomyocyte-specific loss of neurofibromin promotes cardiac hypertrophy and dysfunction through activation of the fetal gene program
The neurofibromin GAP-related domain rescues endothelial but not neural crest development in Nf1(–/–) mice
Neurofibromatosis type I (NF1; also known as von Recklinghausen’s disease) is a common autosomal-dominant condition primarily affecting neural crest–derived tissues. The disease gene, NF1, encodes neurofibromin, a protein of over 2,800 amino acids that contains a 216–amino acid domain with Ras–GTPase-activating protein (Ras-GAP) activity. Potential therapies for NF1 currently in development and being tested in clinical trials are designed to modify NF1 Ras-GAP activity or target downstream effectors of Ras signaling. Mice lacking the murine homolog (Nf1) have mid-gestation lethal cardiovascular defects due to a requirement for neurofibromin in embryonic endothelium. We sought to determine whether the GAP activity of neurofibromin is sufficient to rescue complete loss of function or whether other as yet unidentified functions of neurofibromin might also exist. Using cre-inducible ubiquitous and tissue-specific expression, we demonstrate that the isolated GAP-related domain (GRD) rescued cardiovascular development in Nf1(–/–) embryos, but overgrowth of neural crest–derived tissues persisted, leading to perinatal lethality. These results suggest that neurofibromin may possess activities outside of the GRD that modulate neural crest homeostasis and that therapeutic approaches solely aimed at targeting Ras activity may not be sufficient to treat tumors of neural crest origin in NF1
Design of High-Performance and General-Purpose Satellite Management Unit Based on Rad-Hard Multi-Core SoCand Linux
Since deep space exploration tasks, such as space gravitational wave detection, put forward increasingly higher requirements for the satellite platform, the scale and complexity of the satellite management unit (SMU) software are also increasing, and the trend of intelligentization is showing. It is difficult for the traditional SMU based on single-core system on chip (SoC) to meet the various requirements brought by the above trends. This paper presents a high-performance general-purpose SMU design. Based on rad-hard multi-core SoC, we configure and tailor Linux, and design an SMU software architecture with three modes. It has the characteristics of high performance, high reliability, general purpose and scalability, which can meet the needs of the SMU of future complex satellites. Finally, through the application experiment in the background of the space gravitational wave detection project, the performance and application prospect of our proposed SMU are demonstrated