11 research outputs found
Comparative studies of urolithins and their phase II metabolites on macrophage and neutrophil functions
Contribution of C-glucosidic ellagitannins to Lythrum salicaria L. influence on pro-inflammatory functions of human neutrophils
A Bayesian Framework for XML Information Retrieval: Searching and Learning with the INEX Collection
Stability and transformations of raspberry (Rubus idaeus L.) ellagitannins in aqueous solutions
Antimicrobial and antioxidant potential of different solvent extracts of the medicinal plant Geum urbanum L.
Measuring sustainable development in the education area using multi-criteria methods: a case study
Profile of bioactive compounds in Nymphaea alba L. leaves growing in Egypt: hepatoprotective, antioxidant and anti-inflammatory activity
Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents
The biological effects of urolithins remain poorly characterized, despite wide-spread human exposure via the dietary consumption of their metabolic precursors, the ellagitannins, which are found in the pomegranate fruit, as well as in nuts and berries. We identified urolithin A (UA) as a first-in-class natural compound that induces mitophagy both in vitro and in vivo following oral consumption. In C. elegans, UA prevented the accumulation of dysfunctional mitochondria with age and extended lifespan. Likewise, UA prolonged normal activity during aging in C. elegans, including mobility and pharyngeal pumping, while maintaining mitochondrial respiratory capacity. These effects translated to rodents, where UA improved exercise capacity in two different mouse models of age-related decline of muscle function, as well as in young rats. Our findings highlight the health benefits of urolithin A and its potential application in strategies to improve mitochondrial and muscle function