A successful history: probiotics and their potential as antimicrobials,

Introduction: Probiotics are living, non-pathogenic microorganisms (bacteria) that enter through diet in the human body, live during their passage through the gastrointestinal (GI) tract and are beneficial to health. They have become popular in recent years as a way of improving human health through nutrition. This review aims to discuss the efficacy of probiotics for the supportive therapy of certain clinical conditions, especially infectious diseases, as reported in a number of studies, even though some concerns about their safety still remain. Areas covered: This paper will review the history of probiotics, from ancient ages to date, and the evolution of their use in clinical practice. The study is based on both personal professional experience of the authors and a comprehensive literature analysis, including old documents from libraries, searching the related biological and clinical data on Scopus, Web of Science, PubMed, EMBASE, also using the “cited by” and “similar articles” options available in PubMed. Expert opinion: Not all researchers agree about the safety and real efficacy of probiotics in common conditions, especially infective diseases. However, the use of probiotics for clinical conditions that may be improved by consumption of these dietary supplements should be considered as a possible supportive therapy in select patients

Conversações sobre a "boa morte": o debate bioético acerca da eutanásia Conversations on the "good death": the bioethical debate on euthanasia

A despeito das grandes discussões hodiernas sobre a eutanásia, permanecem ainda muitos pontos em aberto, aparentemente insolúveis, aguardando que um melhor tratamento conceitual seja desenvolvido. Neste âmbito podem ser incluídos os "preconceitos e fundamentalismos" em relação ao tema — a eutanásia ainda é vista como tabu em boa parte da sociedade, especificamente no caso do Brasil —, as imprecisões semânticas do vocábulo e as acérrimas tensões argumentativas em torno do tema — levando-se em consideração os princípios da sacralidade da vida, da qualidade de vida e da autonomia e o argumento da assim chamada "ladeira escorregadia" ou slippery slope. Compor o horizonte de indagação acerca da eutanásia, partindo dos antecedentes históricos em direção a um melhor equacionamento do problema — e delimitação de perspectivas vindouras necessárias à sua melhor compreensão — é, pois, o objetivo do presente ensaio.<br>Despite extensive current debate on euthanasia, many open and apparently unsolvable issues persist, awaiting a better conceptual treatment. The area includes "prejudices and fundamentalisms" in relation to the theme, still viewed as taboo by a major share of society, specifically in the case of Brazil, while semantic imprecision in the term and argumentative tensions surround the issue, focusing on the principles of sacredness of life, quality of life, and autonomy and the so-called "slippery slope" argument. The purpose of the current essay is thus to serve as a sphere of inquiry concerning euthanasia, moving from historical antecedents towards a better solution to the problem and the demarcation of necessary future perspectives for enhanced understanding of the issue