5 research outputs found
Binding of rapamycin analogs to calcium channels and FKBP52 contributes to their neuroprotective activities
- Author
- A. Wood
- Augustine
- B. Ruan
- Baines
- Bito
- Bocquet
- Cameron
- Choi
- D. Liu
- D. von Schack
- E. I. Graziani
- F. Bennett
- F. E. Koehn
- F. Jow
- G. T. Carter
- Ghosh
- Gold
- Graef
- Harper
- Impey
- J. Skotnicki
- K. Pong
- Kissinger
- L. McDonald
- Liu
- Lyons
- M. Abou-Gharbia
- M. Bowlby
- M. L. Mercado
- M. M. Zaleska
- M. N. Pangalos
- Martin
- Norris
- Opatowsky
- P. H. Reinhart
- Pichler
- Platika
- R. A. Crozier
- R. L. Magolda
- S. Liang
- Sharkey
- Steiner
- Steiner
- Summers
- X. Feng
- Y. Chen
- Yasutsune
- Publication venue
- National Academy of Sciences
- Publication date
- Field of study
Rapamycin is an immunosuppressive immunophilin ligand reported as having neurotrophic activity. We show that modification of rapamycin at the mammalian target of rapamycin (mTOR) binding region yields immunophilin ligands, WYE-592 and ILS-920, with potent neurotrophic activities in cortical neuronal cultures, efficacy in a rodent model for ischemic stroke, and significantly reduced immunosuppressive activity. Surprisingly, both compounds showed higher binding selectivity for FKBP52 versus FKBP12, in contrast to previously reported immunophilin ligands. Affinity purification revealed two key binding proteins, the immunophilin FKBP52 and the β1-subunit of L-type voltage-dependent Ca2+ channels (CACNB1). Electrophysiological analysis indicated that both compounds can inhibit L-type Ca2+ channels in rat hippocampal neurons and F-11 dorsal root ganglia (DRG)/neuroblastoma cells. We propose that these immunophilin ligands can protect neurons from Ca2+-induced cell death by modulating Ca2+ channels and promote neurite outgrowth via FKBP52 binding
Oxidic Semiconductor Gas Sensors
- Author
- AM Stoneham
- B Bowker
- BC Tofield
- C Clement
- C Pijolat
- CT Au
- D Kohl
- DE Williams
- E Fresart de
- EW Thornton
- FA Cotton
- G Ghiotti
- G Heiland
- G Heiland
- G Tournier
- G.W. Wang
- GC Bond
- GC Bond
- H Dannetun
- H Jacobs
- H Jacobs
- J Lux
- J Zacheja
- J.F. McAleer
- JA Rodriguez
- JC Riviere
- JF McAleer
- JM Vohs
- JOW Norris
- K Stiles
- K Stiles
- K Takahata
- K Tamaru
- KD Schierbaum
- KH Kim
- M Egashira
- M Peukert
- ME Warwick
- N Murakami
- N Yamazoe
- N Yamazoe
- PB Weisz
- PG Harrison
- PG Harrison
- PG Harrison
- PG Harrison
- PG Harrison
- PG Harrison
- PG Harrison
- PG Harrison
- R Huck
- RG Egdell
- RG Egdell
- S Doniach
- S Munnix
- S Narayanan
- S Saito
- SJ Gentry
- SJ Gentry
- SR Morrison
- SR Morrison
- T Kobayashi
- T Seiyama
- U Böttger
- V Sommer
- W Bytyn
- W Göpel
- W Mokwa
- W Mokwa
- W Platen
- W Thoren
- W Thoren
- Y Matsuurka
- Y Nakamura
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1992
- Field of study
Semiconductor Gas Sensors Based on SnO2 Thick Films
- Author
- A Accorsi
- A Harkoma
- A Harkoma-Mattila
- A Ylinampa
- AA Saaman
- AM Stoneham
- AM Stoneham
- C Pijolat
- CG Fonstad
- D Kohl
- D Kohl
- DE Williams
- DE Williams
- DH Lee
- DJ Dwyer
- E Fresart de
- EI Levin
- EM Logothetis
- EM Logothetis
- FJ Arlinghaus
- G Heiland
- G Sberveglieri
- H Chon
- H Eicker
- H Jacobs
- H Torvela
- H Torvela
- H Torvela
- H Torvela
- H Windischman
- HD Vine Le
- J Bardeen
- J Huusko
- J Huusko
- J Mizsei
- J Mizsei
- J Mizsei
- J Robertson
- J Robertson.
- J Sinkkonen
- JF McAleer
- JL Jacquemin
- JOW Norris
- K Takahata
- KD Schierbaum
- L Pirttiaho
- M Nagasawa
- M Nitta
- MC Carotta
- MJ Madou
- N Komori
- N Murakami
- N Yamazoe
- N Yamazoe
- N Yamazoe
- P Geloven Van
- P Romppainen
- P Romppainen
- P Romppainen
- P Romppainen
- P Romppainen
- PB Weisz
- PK Clifford
- PK Clifford
- PK Clifford
- PT Moseley
- R Beard
- R Lalauze
- R Lalauze
- R Lalauze
- RC Yeates
- S Morimoto
- S Munnix
- S Munnix
- S Munnix
- S Samson
- S Semancik
- S Semancik
- S Semancik
- S-C Chang
- SR Morrison
- SR Morrison
- SR Morrison
- SR Morrison
- SR Morrison
- SR Morrison
- T Agekyan
- T Wolkenstein
- V Lantto
- V Lantto
- V Lantto
- V Lantto
- V Lantto
- V Lantto
- V Lantto
- V Lantto
- VA Smyntyna
- W Göpel
- W Göpel
- W Göpel
- W Hagen
- YM Cross
- ZM Jarzebski
- ZM Jarzebski
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1992
- Field of study
Die Viruselemente
- Author
- A Borrel
- A Claude
- A Einstein
- A Gratia
- A Grollman
- A Köhler
- A Köhler
- A Köhler
- A Kühn
- A Schoep
- A Tiselius
- AG Biemond
- AH Eggerth
- AN Rao
- AP Keueger
- AP Krueger
- AP Krueger
- AP Krueger
- AP Krueger
- AS Lazarus
- AS Lazarus
- AW Turner
- BF Howitt
- BJ Krijgsman
- BK Johnson
- BM Duggar
- C Bakus
- C Levaditi
- C Levaditi
- C Levaditi
- C Levaditi
- C Levaditi
- C Levaditi
- C Levaditi
- C Levaditi
- C Levaditi
- C Levaditi
- C Levaditi
- C Levaditi
- C Prausnitz
- CE Clifton
- CH Andrewes
- CS Gibbs
- D Iwanowski
- D Krassnoff
- D MacClement
- D MacClement
- D Ruffilli
- DI Hitchcock
- DM Hetler
- E Abbé
- E Fränkel
- E Hatschek
- E Henriot
- E Henriot
- E Klieneberger
- E Klieneberger
- E Klieneberger
- E Manegold
- E Manegold
- E Paschen
- E Paschen
- E Wollman
- EG Pickels
- ER Norris
- EV Keogh
- EW Schultz
- F D’Herelle
- F Erbe
- F Gerlach
- F Gerlach
- F Gerlach
- F Gerlach
- F Gerlach
- F Gerlach
- F Himmelweit
- F Loeffler
- FC Bawden
- FC Bawden
- FC Bawden
- FE Bartell
- FE Bartell
- FF Lucas
- FF Lucas
- FF Tang
- FF Tang
- FF Tang
- FM Burnet
- FM Burnet
- FM Burnet
- FM Burnet
- FM Burnet
- FM Burnet
- FM Burnet
- FO Holmes
- FO Holmes
- G Busch
- G Eliava
- G Ettisch
- G Jung
- G Seiffert
- G Seiffert
- GG Jones
- GM Findlay
- GS Walpole
- H Bechhold
- H Bechhold
- H Bechhold
- H Bechhold
- H Bechhold
- H Bechhold
- H Bechhold
- H Bechhold
- H Bechhold
- H Bechhold
- H Helmholtz
- H Stassano
- H Wkighton
- H Yaoi
- H Yaoi
- H Yaoi
- H Yaoi
- H Zinsser
- HC Allisbaugh
- HF Pierce
- HH Thornberry
- HH Thornberry
- HK Ward
- HM Shoetensack
- HM Shoetensack
- HO Halvorson
- HR Cox
- HS Loring
- I Eriksson-Quensel
- I Modrow
- IA Galloway
- IA Galloway
- IA Galloway
- IA Galloway
- IA Galloway
- IJ Kligler
- IN Asheshov
- IN Asheshov
- J Biscoe
- J Bronfenbrenner
- J Craigie
- J Craigie
- J Duclaux
- J Furth
- J Loeb
- J Marchal
- J McIntosh
- J McIntosh
- J Smiles
- J Smiles
- JC Broom
- JC Broom
- JCG Ledingham
- JCG Ledingham
- JD Ferry
- JD Ferry
- JE Barnard
- JE Barnard
- JE Barnard
- JE Barnard
- JE Barnard
- JE Barnard
- JE Barnard
- JE Barnard
- JE Barnard
- JH Bauer
- JH Bauer
- JH Bauer
- JH Bauer
- JH Bauer
- JH Bauer
- JH Bauer
- JH Bauer
- JH Northrop
- JJ Quigley
- JM Nelson
- JOW Bland
- JR Perdrait
- JW Beams
- JW Beard
- JW Beard
- JW Beard
- JW McBain
- JW McBain
- JW McBain
- JW McBain
- K Herzberg
- K Herzberg
- K Ono
- KH Tadxerman
- KM Smith
- KM Smith
- L Nattan-Larrier
- LC Martin
- LC Martin
- LC Martin
- LC Martin
- M Guerout
- M Schlesinger
- M Schlesinger
- M Schlesinger
- M Schlesinger
- M Schlesinger
- M Schlesinger
- M Schlesinger
- M Schlesinger
- M Theiler
- N Bjerrum
- N Brown
- O Risse
- O Risse
- O Teutschlaender
- P Andriewsky
- P Fildes
- P Frosch
- P Frosch
- P Frosch
- P Girard
- P Grabar
- P Grabar
- P Grabar
- P Haktley
- P Mutzenbecher von
- P Mutzenbecher von
- P Thygeson
- P Thygeson
- P Thygeson
- PK Olitsky
- PKH Hagemann
- PKH Hagemann
- PP Laidlaw
- R Brinkman
- R Daubney
- R Zsigmondy
- RA Gesell
- Rayleigh
- RS Vichélessky
- RT Parker
- RWG Wyckoff
- RWG Wyckoff
- RWG Wyckoff
- RWG Wyckoff
- RWG Wyckoff
- S Strugger
- SAP Ederer
- SJ Folley
- SL Bigelow
- SL Bigelow
- SP Bedson
- SW Cole
- T Svedberg
- T Svedberg
- T Svedberg
- T Svedberg
- T Svedberg
- UE Shope
- W Levinthal
- W Mendelsohn
- WG MacCallum
- WJ Elford
- WJ Elford
- WJ Elford
- WJ Elford
- WJ Elford
- WJ Elford
- WJ Elford
- WJ Elford
- WJ Elford
- WJ Elford
- WJ Elford
- WJ Elford
- WJ Elford
- WJ Elford
- WJ Elford
- WJ Elford
- WJ Elford
- WJ Elford
- WJ Elford
- WJ Elford
- WJ Elford
- WJ Elford
- WJ Elford
- WJ Elford
- WJ Elford
- WM Stanley
- WM Stanley
- WM Stanley
- WM Stanley
- WM Stanley
- WM Stanley
- Y Miyagawa
- ZW Jermoljewa
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1938
- Field of study
Germ Cell Tumors of the Ovary
- Author
- A Gonzalez-Angulo
- A Gonzalez-Licea
- A Gordon
- A Peyron
- A Plaut
- A Sell
- A Sjovall
- A Takeda
- A Talerman
- A Talerman
- A Talerman
- A Talerman
- A Talerman
- A Talerman
- A Talerman
- A Talerman
- A Talerman
- A Talerman
- A Talerman
- A Talerman
- A Talerman
- A Talerman
- A Talerman
- A Talerman
- A Talerman
- A Talerman
- A Talerman
- A Talerman
- A Talerman
- A Talerman
- AF Jatoi
- AF Strauss
- AG Lacson
- AH Qizilbash
- AJ Garvin
- AJ Jacobs
- AJ Tiltman
- AM Hain
- AM Mackay
- AM Saunders
- AR Climie
- AT Hertig
- AT Hertig
- B Gans
- B Gondos
- B Norgaard-Pedersen
- B Sporrong
- BS Cutler
- C Nystrom
- C Toker
- C Zaloudek
- CD McCullough
- CG Bergstrand
- CG Moertel
- CH Lingeman
- CI Goldsmith
- CM Weldon-Linne
- CT Anderson Jr
- CW Bardin
- CW Mueller
- CW Taylor
- D Bernstein
- D Bhatena
- D Gitlin
- D Gitlin
- D Gitlin
- D Linder
- D Linder
- D Linder
- D Payne
- DA Bell
- DB Rulon
- DG McKay
- DG McKay
- DH Collins
- DJ Bartlett
- DJ Jenkyn
- DM Burkons
- DM Gershenson
- DM Gershenson
- DM Gershenson
- DP Goldstein
- E Alenghat
- E Bergher Bacalao de
- E Bjorkholm
- E Novak
- E Novak
- E Novak
- E Pantoja
- E Pantoja
- E Witschi
- EA Theiss
- ED Williams
- ED Williams
- EF Schmitz
- EJ Livnat
- EJ Wilkinson
- ER Novak
- ER Novak
- F Cabanne
- F Flamant
- F Gonzalez-Crussi
- F Kommoss
- F Kommoss
- FA Tavassoli
- FF Nogales Jr
- FF Nogales Jr
- FG Smith
- FJ Ansfield
- FJ Dixon
- FT Serratoni
- G Krepart
- G Marrubini
- G Teilum
- G Teilum
- G Teilum
- G Teilum
- G Teilum
- G Teilum
- G Teilum
- G Teilum
- G Teilum
- G Ueda
- G Ueda
- GA Awais
- GB Pierce Jr
- GB Pierce Jr
- GB Pierce Jr
- GB Pierce Jr
- GB Pierce Jr
- GB Pierce Jr
- GB Pierce Jr
- GB Pierce Jr
- GD Levine
- GD Malkasian Jr
- GD Malkasian Jr
- GD Malkasian Jr
- GE Seegar
- GF Vawter
- GK Jacobsen
- GK Jimerson
- GK Jimerson
- GM Kleiman
- GM Thomas
- GO Malkasian Jr
- GWH Stamp
- H Battifora
- H Braunstein
- H Fox
- H Fox
- H Gallion
- H Jedberg
- H Kawahara
- H Uzisima
- HA Zondag
- HB Turner
- HF Bettinger
- HF Schellhas
- HF Schellhas
- HF Schellhas
- HJ Bagg
- HJ Norris
- HJ Norris
- HJ Ramsey
- HL Judd
- HM Oliver
- HO Williamson
- HR Pratt-Thomas
- HS Galager
- HZ Klein
- I Damjanov
- I Neigus
- I Nieminen
- I Teilmann
- IJ Park
- J Bestie
- J Died
- J Ewing
- J Gillman
- J Mathieu
- J Prat
- J Salet
- J Solomon
- J Teter
- J Teter
- J Teter
- J Teter
- JA Lynn
- JA Whelton
- JA Wider
- JA Wider
- JB Dalgaard
- JB Smith
- JC Chumas
- JC Chumas
- JD Woodruff
- JD Woodruff
- JD Woodruff
- JE Bradof
- JH Freel
- JL Breen
- JL Breen
- JL Breen
- JL Grosfeld
- JL Rutgers
- JL Rutgers
- JM Lord
- JM Parrington
- JM Parrington
- JOW Beilby
- JP Forney
- JP Smith
- JP Smith
- JR Brown
- JS Beck
- JT Duhig
- JW Berg
- K Boczkowski
- K Griffiths
- K Hameed
- K Higuchi
- K Hou-Jensen
- K Liebert
- K Nomura
- K Wurster
- KD Shah
- KG Barry
- L Lien
- L Overbeck
- L Santesson
- L Santesson
- LA Asadourian
- LA Emge
- LB Felmus
- LC Simard
- LC Stevens
- LC Stevens
- LC Stevens
- LH Einhorn
- LI Rose
- LR Cooperman
- LS Hirschfield
- M Bailas
- M Bailas
- M Duval
- M Galton
- M Marin-Padilla
- M Miettinen
- M Miettinen
- M Nakashima
- M Ranchod
- M Szokol
- M Wisniewski
- MA Afridi
- MA Dawson
- MA Greco
- MA Sens
- MB Cohen
- MB Cohen
- MC Anderson
- ME King
- ME King
- ME King
- MH Matz
- MH Rashad
- MH Taylor
- MK Senterman
- ML Samuels
- MM Abitol
- MM Melicow
- MR Abell
- MS Krumerman
- MT Mazur
- NA Janovski
- NB Atkin
- NB Atkin
- NB Atkin
- NB Friedman
- NB Friedman
- NE Larson
- NR Rao
- O Koller
- P Aguirre
- P Masson
- P Pedowitz
- PA Caruso
- PA Corfman
- PA Stagno
- PB Chretien
- PB Clement
- PE Hughesdon
- PE Hughesdon
- PE Palmer
- PE Schwartz
- PG McDonough
- PG McDonough
- PH Lange
- QC Haan De
- R Albrechtsen
- R Dekmezian
- R Meyer
- RA Marcial-Rojas
- RB Arhelger
- RC Ulirsch
- RD Neubecker
- RE Scully
- RE Scully
- RE Scully
- RE Scully
- RE Scully
- RE Scully
- RE Scully
- RG Wieland
- RH Thoeny
- RH Young
- RH Young
- RH Young
- RJ Kurman
- RJ Kurman
- RJ Kurman
- RL Carleton
- RL Warkel
- RP Vance
- RR Kelley
- RR Snyder
- RS Azoury
- RW Evans
- RW Evans
- RW Huntington Jr
- RW Huntington Jr
- RW Huntington Jr
- S Allard
- S Borushek
- S Brody
- S Fujii
- S Kay
- S Sailer
- S Sailer
- S Tokuoka
- SB Gusberg
- SD Dandia
- SD Frazier
- SE Erez
- SF Serov
- SG Subbuswamy
- SH Dikman
- SJ Robboy
- SJ Robboy
- SJ Robboy
- SJ Robboy
- SJ Robboy
- SK Patel
- SM Jackson
- SNJ Nielsen
- T Engel
- T Ishida
- T Itoh
- T Shirai
- TM Abbot
- TM Ulbright
- TM Ulbright
- TR Kazancigil
- V Hingorani
- VR Wheatley
- W Schiller
- W Schiller
- WF Peterson
- WF Peterson
- WF Peterson
- WH Sternberg
- WJ Blackwell
- WM Thurlbeck
- WR Hart
- WR Hart
- Y Dayal
- Y Erhan
- Y Tsuchida
- Z Gibas
- Z Gibas
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1994
- Field of study