111 research outputs found
Gravitational field around a time-like current-carrying screwed cosmic string in scalar-tensor theories
In this paper we obtain the space-time generated by a time-like
current-carrying superconducting screwed cosmic string(TCSCS). This
gravitational field is obtained in a modified scalar-tensor theory in the sense
that torsion is taken into account. We show that this solution is comptible
with a torsion field generated by the scalar field . The analysis of
gravitational effects of a TCSCS shows up that the torsion effects that appear
in the physical frame of Jordan-Fierz can be described in a geometric form
given by contorsion term plus a symmetric part which contains the scalar
gradient. As an important application of this solution, we consider the linear
perturbation method developed by Zel'dovich, investigate the accretion of cold
dark matter due to the formation of wakes when a TCSCS moves with speed and
discuss the role played by torsion. Our results are compared with those
obtained for cosmic strings in the framework of scalar-tensor theories without
taking torsion into account.Comment: 21 pages, no figures, Revised Version, presented at the "XXIV-
Encontro Nacional de Fisica de Particulas e Campos ", Caxambu, MG, Brazil, to
appear in Phys. Rev.
Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTICâHF: baseline characteristics and comparison with contemporary clinical trials
Aims:
The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTICâHF) trial. Here we describe the baseline characteristics of participants in GALACTICâHF and how these compare with other contemporary trials.
Methods and Results:
Adults with established HFrEF, New York Heart Association functional class (NYHA)ââ„âII, EF â€35%, elevated natriuretic peptides and either current hospitalization for HF or history of hospitalization/ emergency department visit for HF within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokineticâguided dosing: 25, 37.5 or 50âmg bid). 8256 patients [male (79%), nonâwhite (22%), mean age 65âyears] were enrolled with a mean EF 27%, ischemic etiology in 54%, NYHA II 53% and III/IV 47%, and median NTâproBNP 1971âpg/mL. HF therapies at baseline were among the most effectively employed in contemporary HF trials. GALACTICâHF randomized patients representative of recent HF registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressureâ<â100âmmHg (n = 1127), estimated glomerular filtration rate <â30âmL/min/1.73 m2 (n = 528), and treated with sacubitrilâvalsartan at baseline (n = 1594).
Conclusions:
GALACTICâHF enrolled a wellâtreated, highârisk population from both inpatient and outpatient settings, which will provide a definitive evaluation of the efficacy and safety of this novel therapy, as well as informing its potential future implementation
Observations of the Sun at Vacuum-Ultraviolet Wavelengths from Space. Part II: Results and Interpretations
Untersuchungen zur Moeglichkeit der Reduzierung von Fegedampfverlusten bei der thermischen Entgasung von Kesselspeisewasser Abschlussbericht
SIGLEAvailable from TIB Hannover: F02B585 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDeutsche Bundesstiftung Umwelt, Osnabrueck (Germany)DEGerman
Interfacial layer development in hot-dip galvanneal coatings on interstitial free (IF) steel
Control of Perfusable Microvascular Network Morphology Using a Multiculture Microfluidic System
Mouse Small eye results from mutations in a paired-like homeobox-containing gene.
Small eye (Sey) in mouse is a semidominant mutation which in the homozygous condition results in the complete lack of eyes and nasal primordia. On the basis of comparative mapping studies and on phenotypic similarities, Sey has been suggested to be homologous to congenital aniridia (lack of iris) in human1,2. A candidate gene for the aniridia (AN) locus at 11p13 has been isolated by positional cloning3 and its sequence and that of the mouse homologue has been established (C.T., manuscript in preparation). This gene belongs to the paired-like class of developmental genes first described in Drosophila which contain two highly conserved motifs, the paired box and the homeobox 4,5. In vertebrates, genes which encode the single paired domain as well as those which express both motifs have been described as the Pax multigene family6-10. A Pax gene recently described as Pax-611,12 is identical to the mouse homologue of the candidate aniridia gene. Here we report the analysis of three independent Sey alleles and show that indeed this gene is mutated and that the mutations would predictably interrupt gene function
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