Biomaktens gisseltak på kroppene

I denne oppgaven skal jeg argumentere for hvorfor biomaktbegrepet til Foucault undergraver autonomi. Dette skal jeg sette opp mot et liberalistisk maktsyn for å vise forskjellene mellom de og sette de opp mot hverandre og hvordan begge håndterer autonomi. Jeg går gjennom Foucault sitt maktbegrep, redegjør for biomakt, governmentality og teknologier om selvet for å underbygge argumentasjonen om hvordan biomakten undergraver autonomi.In this thesis, I will argue why Foucault's concept of biopower undermines autonomy. I will contrast this with a liberal view of power to show the differences between them and pit them against each other and how both deal with autonomy. I go through Foucault's concept of power, explaining biopower, governmentality and technologies about the self to support the argument about how biopower undermines autonomy

The Shear Stress-Induced Transcription Factor KLF2 Affects Dynamics and Angiopoietin-2 Content of Weibel-Palade Bodies

BACKGROUND: The shear-stress induced transcription factor KLF2 has been shown to induce an atheroprotective phenotype in endothelial cells (EC) that are exposed to prolonged laminar shear. In this study we characterized the effect of the shear stress-induced transcription factor KLF2 on regulation and composition of Weibel-Palade bodies (WPBs) using peripheral blood derived ECs. METHODOLOGY AND PRINCIPAL FINDINGS: Lentiviral expression of KLF2 resulted in a 4.5 fold increase in the number of WPBs per cell when compared to mock-transduced endothelial cells. Unexpectedly, the average length of WPBs was significantly reduced: in mock-transduced endothelial cells WPBs had an average length of 1.7 µm versus 1.3 µm in KLF2 expressing cells. Expression of KLF2 abolished the perinuclear clustering of WPBs observed following stimulation with cAMP-raising agonists such as epinephrine. Immunocytochemistry revealed that WPBs of KLF2 expressing ECs were positive for IL-6 and IL-8 (after their upregulation with IL-1β) but lacked angiopoietin-2 (Ang2), a regular component of WPBs. Stimulus-induced secretion of Ang2 in KLF2 expressing ECs was greatly reduced and IL-8 secretion was significantly lower. CONCLUSIONS AND SIGNIFICANCE: These data suggest that KLF2 expression leads to a change in size and composition of the regulated secretory compartment of endothelial cells and alters its response to physiological stimuli