4 research outputs found
The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance
INTRODUCTION
Investment in Africa over the past year with regard to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing has led to a massive increase in the number of sequences, which, to date, exceeds 100,000 sequences generated to track the pandemic on the continent. These sequences have profoundly affected how public health officials in Africa have navigated the COVID-19 pandemic.
RATIONALE
We demonstrate how the first 100,000 SARS-CoV-2 sequences from Africa have helped monitor the epidemic on the continent, how genomic surveillance expanded over the course of the pandemic, and how we adapted our sequencing methods to deal with an evolving virus. Finally, we also examine how viral lineages have spread across the continent in a phylogeographic framework to gain insights into the underlying temporal and spatial transmission dynamics for several variants of concern (VOCs).
RESULTS
Our results indicate that the number of countries in Africa that can sequence the virus within their own borders is growing and that this is coupled with a shorter turnaround time from the time of sampling to sequence submission. Ongoing evolution necessitated the continual updating of primer sets, and, as a result, eight primer sets were designed in tandem with viral evolution and used to ensure effective sequencing of the virus. The pandemic unfolded through multiple waves of infection that were each driven by distinct genetic lineages, with B.1-like ancestral strains associated with the first pandemic wave of infections in 2020. Successive waves on the continent were fueled by different VOCs, with Alpha and Beta cocirculating in distinct spatial patterns during the second wave and Delta and Omicron affecting the whole continent during the third and fourth waves, respectively. Phylogeographic reconstruction points toward distinct differences in viral importation and exportation patterns associated with the Alpha, Beta, Delta, and Omicron variants and subvariants, when considering both Africa versus the rest of the world and viral dissemination within the continent. Our epidemiological and phylogenetic inferences therefore underscore the heterogeneous nature of the pandemic on the continent and highlight key insights and challenges, for instance, recognizing the limitations of low testing proportions. We also highlight the early warning capacity that genomic surveillance in Africa has had for the rest of the world with the detection of new lineages and variants, the most recent being the characterization of various Omicron subvariants.
CONCLUSION
Sustained investment for diagnostics and genomic surveillance in Africa is needed as the virus continues to evolve. This is important not only to help combat SARS-CoV-2 on the continent but also because it can be used as a platform to help address the many emerging and reemerging infectious disease threats in Africa. In particular, capacity building for local sequencing within countries or within the continent should be prioritized because this is generally associated with shorter turnaround times, providing the most benefit to local public health authorities tasked with pandemic response and mitigation and allowing for the fastest reaction to localized outbreaks. These investments are crucial for pandemic preparedness and response and will serve the health of the continent well into the 21st century
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PRELIMINARY BIBLIOMETRICS OF PLANT-DERIVED HEALTH FOODS OVER THE LAST DECADE IN THE SCOPUS DATABASE
A growing interest in the medicinal values of foods can be assessed by the rapidity of research publications on foods that exert health benefits. Many foods that are of health benefit to humans, irrespective of their origin (plants, animals) and subjected level of processing (fermentation, cooking, warming, freezing, vacuumpackaging), are variously designated in scientific literature based on their biofunction. Plant-based foodsâ application vagaries, momentum, and research orientation regarding their health functionality awareness are scarcely studied by bibliometrics from a global perspective. Therefore, a bibliometric search was performed on the Scopus database from 2011 (January) to 2021 (April) using a range of search keys covering reports of conceptualized consumable plant-derived foods with health-promoting potential. A total of 362,309 documents on medicinal foods of plant origin were obtained from the database. The data were obtained in comma-separated values (CSV) format and analyzed with Microsoft Excel tools. Of the total documents from the Scopus database on the study, 8.01% (29,036) were contributed by African researchers. Comparatively, lead contributors (global; Africa) by group disciplines include biochemistry, genetics, and molecular biology (118,896; 8,236); pharmacology, toxicology, and pharmaceutics (104,530; 8,581); agricultural and biological sciences (99,053; 9,610), respectively. Similarly, lead contributors by country include China (73,977), India (44,898), USA (44,582), and Nigeria (4,680). This observation shows a higher research propensity towards plant-derived medicinal foods in populous nations due to factors like dietary culture, an increase in vegan and health-nutrition enthusiast populations, and the emergent concerns with the therapeutic use of synthetic pharmaceuticals. The analyzed results gave insights into the research orientation of plant-based foods that promote human health on a global stage and provide future research directions. Knowledge of the various application of plant-based foods may potentiate the United Nations Sustainable Goals initiative on responsible consumption (SDG 12), and health and wellbeing (SDG 3) among the global population