12 research outputs found
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Can a colonial flag become a banner for democracy? The Case of the Dragon and Lion flag and the 2019 Hong Kong protests
Why did Hong Kong protestors choose a symbol of former oppression – the old colonial flag – as a banner for their fight for democracy, rights and autonomy in 2019? We propose to answer this puzzle by studying the colonial-era flag as a displacement device. The waving of the colonial-era flag is shown to induce non-linear temporal and extraterritorial displacements, as well as contradictory interpretations of Hong Kong’s core values, national sovereignty and cultural identity. The flag’s displacements are amplified against the contested colonial history of the former British enclave. Conceptually, this pragmatic definition of the flag moves beyond approaches that study flags as representations of a structure of symbolic meaning. The flag is neither an unimportant prop nor is it a free-floating signifier; its materiality elicits significant political effects. Methodologically, this translates into an exploration of the flag’s second-order agency. The old colonial-era Hong Kong flag, in combination with discourse and institutional arrangements, is shown to be integral to contentious politics. The flag and its displacements shed new light on a city uneasy with its past, dissatisfied with its present and uncertain about its future. </jats:p
Low molecular weight heparins use in pregnancy: a practice survey from Greece and a review of the literature
Interchromosomal effect in carriers of translocations and inversions assessed by preimplantation genetic testing for structural rearrangements (PGT-SR)
Epigenetics in renal cell cancer: mechanisms and clinical applications
Renal cell carcinoma (RCC) is characterized by an infrequent number of somatic mutations. By contrast, epigenetic aberrations are commonly found in RCC, indicating that epigenetic reprogramming is an important event in RCC development. Epigenetic alterations comprise several different aberrations, such as changes in histone modifications, DNA methylation, and microRNA levels, and occur in the most important signalling pathways in RCC, such as the von Hippel-Lindau disease tumour suppressor (VHL)-hypoxia-inducible factor (HIF) pathway, the WNT-beta-catenin pathway, and pathways involved in epithelial-mesenchymal transition. Owing to their involvement in these pathways and frequent occurrence in RCC, epigenetic alterations are regarded as potential biomarkers for the early detection of disease and for prediction of prognosis and treatment response. In addition, most of these alterations are potentially reversible, so they also provide new targets for therapy. At the moment, epigenetic biomarkers for RCC are not being used in clinical practice, but targeted epigenetic therapies are under investigation. Understanding the extent of epigenetic changes occurring in RCC and the mechanisms by which they influence disease progression and treatment response, as well as knowledge of current research on biomarkers and treatments, is crucial to successful clinical translation of epigenetics in RCC