KiDS+VIKING-450: Cosmic shear tomography with optical+infrared data

We present a tomographic cosmic shear analysis of the Kilo-Degree Survey (KiDS) combined with the VISTA Kilo-Degree Infrared Galaxy Survey. This is the first time that a full optical to near-infrared data set has been used for a wide-field cosmological weak lensing experiment. This unprecedented data, spanning 450 deg2, allows us to significantly improve the estimation of photometric redshifts, such that we are able to include robustly higher-redshift sources for the lensing measurement, and – most importantly – to solidify our knowledge of the redshift distributions of the sources. Based on a flat ΛCDM model we find S8 ≡ σ8 Ωm/0.3 = 0.737+0.040−0.036 in a blind analysis from cosmic shear alone. The tension between KiDS cosmic shear and the Planck-Legacy CMB measurements remains in this systematically more robust analysis, with S8 differing by 2.3σ. This result is insensitive to changes in the priors on nuisance parameters for intrinsic alignment, baryon feedback, and neutrino mass. KiDS shear measurements are calibrated with a new, more realistic set of image simulations and no significant B-modes are detected in the survey, indicating that systematic errors are under control. When calibrating our redshift distributions by assuming the 30-band COSMOS-2015 photometric redshifts are correct (following the Dark Energy Survey and the Hyper Suprime-Cam Survey), we find the tension with Planck is alleviated. The robust determination of source redshift distributions remains one of the most challenging aspects for future cosmic shear surveys

KiDS-1000 catalogue: Redshift distributions and their calibration

We present redshift distribution estimates of galaxies selected from the fourth data release of the Kilo-Degree Survey over an area of ∼1000 deg2 (KiDS-1000). These redshift distributions represent one of the crucial ingredients for weak gravitational lensing measurements with the KiDS-1000 data. The primary estimate is based on deep spectroscopic reference catalogues that are re-weighted with the help of a self-organising map (SOM) to closely resemble the KiDS-1000 sources, split into five tomographic redshift bins in the photometric redshift range 0.1 < zB ≤ 1.2. Sources are selected such that they only occupy that volume of nine-dimensional magnitude-space that is also covered by the reference samples (‘gold’ selection). Residual biases in the mean redshifts determined from this calibration are estimated from mock catalogues to be ≲0.01 for all five bins with uncertainties of ∼0.01. This primary SOM estimate of the KiDS-1000 redshift distributions is complemented with an independent clustering redshift approach. After validation of the clustering-z on the same mock catalogues and a careful assessment of systematic errors, we find no significant bias of the SOM redshift distributions with respect to the clustering-z measurements. The SOM redshift distributions re-calibrated by the clustering-z represent an alternative calibration of the redshift distributions with only slightly larger uncertainties in the mean redshifts of ∼0.01 − 0.02 to be used in KiDS-1000 cosmological weak lensing analyses. As this includes the SOM uncertainty, clustering-z are shown to be fully competitive on KiDS-1000 data

Testing KiDS cross-correlation redshifts with simulations

Measuring cosmic shear in wide-field imaging surveys requires accurate knowledge of the redshift distribution of all sources. The clustering-redshift technique exploits the angular cross-correlation of a target galaxy sample with unknown redshifts and a reference sample with known redshifts. It represents an attractive alternative to colour-based methods of redshift calibration. Here we test the performance of such clustering redshift measurements using mock catalogues that resemble the Kilo-Degree Survey (KiDS). These mocks are created from the MICE simulation and closely mimic the properties of the KiDS source sample and the overlapping spectroscopic reference samples. We quantify the performance of the clustering redshifts by comparing the cross-correlation results with the true redshift distributions in each of the five KiDS photometric redshift bins. Such a comparison to an informative model is necessary due to the incompleteness of the reference samples at high redshifts. Clustering mean redshifts are unbiased at |Δz|< 0.006 under these conditions. The redshift evolution of the galaxy bias of the reference and target samples represents one of the most important systematic errors when estimating clustering redshifts. It can be reliably mitigated at this level of precision using auto-correlation measurements and self-consistency relations, and will not become a dominant source of systematic error until the arrival of Stage-IV cosmic shear surveys. Using redshift distributions from a direct colour-based estimate instead of the true redshift distributions as a model for comparison with the clustering redshifts increases the biases in the mean to up to |Δz|∼0.04. This indicates that the interpretation of clustering redshifts in real-world applications will require more sophisticated (parameterised) models of the redshift distribution in the future. If such better models are available, the clustering-redshift technique promises to be a highly complementary alternative to other methods of redshift calibration

KiDS-1000: Cross-correlation with Planck cosmic microwave background lensing and intrinsic alignment removal with self-calibration

CONTEXT: Galaxy shear and cosmic microwave background (CMB) lensing convergence cross-correlations contain additional information on cosmology with respect to auto-correlations. While remaining immune to certain systemic effects, these cross-correlations are nonetheless affected by the galaxy's intrinsic alignments (IA). These effects may, in fact, be responsible for the reported low lensing amplitude of the galaxy shear × CMB convergence cross-correlations, compared to the standard Planck ACDM (cosmological constant and cold dark matter) cosmology predictions. AIMS: In this work, we investigate how IA affects the Kilo-Degree Survey (KiDS) galaxy lensing shear and Planck CMB lensing convergence cross-correlation and we compare it to previous treatments, both with and without IA taken into consideration. METHODS: We compared the marginalization over IA parameters and the IA self-calibration (SC) method (with additional observables defined only from the source galaxies) to demonstrate that SC can efficiently break the degeneracy between the CMB lensing amplitude, Alens, and the IA amplitude, AIA. We further investigated how different systematics affect the resulting AIA and Alens and we validated our results with the MICE2 simulation. RESULTS: We find that by including the SC method to constrain IA, the information loss due to the degeneracy between CMB lensing and IA is strongly reduced. The best-fit values are Alens = 0.84-0.22+0.22 and AIA = 0.60-1.03+1.03, while different angular scale cuts can affect Alens by ~10%. We show that an appropriate treatment of the boost factor, cosmic magnification, and photometric redshift modeling is important for obtaining the correct IA and cosmological results

Ectopic A-lattice seams destabilize microtubules

Natural microtubules typically include one A-lattice seam within an otherwise helically symmetric B-lattice tube. It is currently unclear how A-lattice seams influence microtubule dynamic instability. Here we find that including extra A-lattice seams in GMPCPP microtubules, structural analogues of the GTP caps of dynamic microtubules, destabilizes them, enhancing their median shrinkage rate by >20-fold. Dynamic microtubules nucleated by seeds containing extra A-lattice seams have growth rates similar to microtubules nucleated by B-lattice seeds, yet have increased catastrophe frequencies at both ends. Furthermore, binding B-lattice GDP microtubules to a rigor kinesin surface stabilizes them against shrinkage, whereas microtubules with extra A-lattice seams are stabilized only slightly. Our data suggest that introducing extra A-lattice seams into dynamic microtubules destabilizes them by destabilizing their GTP caps. On this basis, we propose that the single A-lattice seam of natural B-lattice MTs may act as a trigger point, and potentially a regulation point, for catastrophe

Testing gravity using galaxy-galaxy lensing and clustering amplitudes in KiDS-1000, BOSS, and 2dFLenS

The physics of gravity on cosmological scales affects both the rate of assembly of large-scale structure and the gravitational lensing of background light through this cosmic web. By comparing the amplitude of these different observational signatures, we can construct tests that can distinguish general relativity from its potential modifications. We used the latest weak gravitational lensing dataset from the Kilo-Degree Survey, KiDS-1000, in conjunction with overlapping galaxy spectroscopic redshift surveys, BOSS and 2dFLenS, to perform the most precise existing amplitude-ratio test. We measured the associated E_{G} statistic with 15 - 20% errors in five Δz = 0.1 tomographic redshift bins in the range 0.2 < z < 0.7 on projected scales up to 100  h^{-1} Mpc. The scale-independence and redshift-dependence of these measurements are consistent with the theoretical expectation of general relativity in a Universe with matter density Ω_{m} = 0.27 ± 0.04. We demonstrate that our results are robust against different analysis choices, including schemes for correcting the effects of source photometric redshift errors, and we compare the performance of angular and projected galaxy-galaxy lensing statistics

Crystal structures of the NO sensor NsrR reveal how its iron-sulfur cluster modulates DNA binding

NsrR from Streptomyces coelicolor (Sc) regulates the expression of three genes through the progressive degradation of its [4Fe–4S] cluster on nitric oxide (NO) exposure. We report the 1.95 Å resolution crystal structure of dimeric holo-ScNsrR and show that the cluster is coordinated by the three invariant Cys residues from one monomer and, unexpectedly, Asp8 from the other. A cavity map suggests that NO displaces Asp8 as a cluster ligand and, while D8A and D8C variants remain NO sensitive, DNA binding is affected. A structural comparison of holo-ScNsrR with an apo-IscR-DNA complex shows that the [4Fe–4S] cluster stabilizes a turn between ScNsrR Cys93 and Cys99 properly oriented to interact with the DNA backbone. In addition, an apo ScNsrR structure suggests that Asn97 from this turn, along with Arg12, which forms a salt-bridge with Asp8, are instrumental in modulating the position of the DNA recognition helix region relative to its major groove

Investigation of a Mesoporous Silicon Based Ferromagnetic Nanocomposite

A semiconductor/metal nanocomposite is composed of a porosified silicon wafer and embedded ferromagnetic nanostructures. The obtained hybrid system possesses the electronic properties of silicon together with the magnetic properties of the incorporated ferromagnetic metal. On the one hand, a transition metal is electrochemically deposited from a metal salt solution into the nanostructured silicon skeleton, on the other hand magnetic particles of a few nanometres in size, fabricated in solution, are incorporated by immersion. The electrochemically deposited nanostructures can be tuned in size, shape and their spatial distribution by the process parameters, and thus specimens with desired ferromagnetic properties can be fabricated. Using magnetite nanoparticles for infiltration into porous silicon is of interest not only because of the magnetic properties of the composite material due to the possible modification of the ferromagnetic/superparamagnetic transition but also because of the biocompatibility of the system caused by the low toxicity of both materials. Thus, it is a promising candidate for biomedical applications as drug delivery or biomedical targeting

Depletion of somatic mutations in splicing-associated sequences in cancer genomes

Abstract Background An important goal of cancer genomics is to identify systematically cancer-causing mutations. A common approach is to identify sites with high ratios of non-synonymous to synonymous mutations; however, if synonymous mutations are under purifying selection, this methodology leads to identification of false-positive mutations. Here, using synonymous somatic mutations (SSMs) identified in over 4000 tumours across 15 different cancer types, we sought to test this assumption by focusing on coding regions required for splicing. Results Exon flanks, which are enriched for sequences required for splicing fidelity, have ~ 17% lower SSM density compared to exonic cores, even after excluding canonical splice sites. While it is impossible to eliminate a mutation bias of unknown cause, multiple lines of evidence support a purifying selection model above a mutational bias explanation. The flank/core difference is not explained by skewed nucleotide content, replication timing, nucleosome occupancy or deficiency in mismatch repair. The depletion is not seen in tumour suppressors, consistent with their role in positive tumour selection, but is otherwise observed in cancer-associated and non-cancer genes, both essential and non-essential. Consistent with a role in splicing modulation, exonic splice enhancers have a lower SSM density before and after controlling for nucleotide composition; moreover, flanks at the 5’ end of the exons have significantly lower SSM density than at the 3’ end. Conclusions These results suggest that the observable mutational spectrum of cancer genomes is not simply a product of various mutational processes and positive selection, but might also be shaped by negative selection