9 research outputs found
Whole genome sequence analysis of the TALLYHO/Jng mouse
- Author
- A McKenna
- A Sadanandam
- B Langmead
- B Magnusson
- B Yalcin
- C Ding
- C Rocha
- C Sztalryd
- CA Baumann
- D Segula
- D Welter
- Donald A. Primerano
- DW Buck 2nd
- E Bruno
- EH Leiter
- EM Gaber
- F Cunningham
- F McMurray
- G Dailey
- Goran Boskovic
- GQ Qu
- H Li
- H Li
- HG Joost
- HS Kang
- HY Won
- I Parusel
- IJ Wagner
- J Chang
- Jacaline K. Parkman
- James Denvir
- JE Ostler
- JH Kim
- JH Kim
- JH Kim
- JK Yisraeli
- Jun Fan
- Jung Han Kim
- K Eilbeck
- K Liu
- K Maeda
- K Matsusue
- K Wong
- KJ Basile
- KT Nguyen
- L Braccini
- M Epstein
- M Hedayati
- M Pigeyre
- MJ Devlin
- N Dai
- N Grarup
- N Sasai
- O Ali
- O Rubio-Cabezas
- P Danecek
- P Keller
- P Kumar
- P Simecek
- PC Ng
- Q Chen
- Q Xia
- RJ Kinsella
- S Neschen
- S Sandaradura
- S Stockler
- SA Melville
- SD Conner
- SG Jin
- SI Sherwani
- SJ Hong
- SM Flannery
- SP Didion
- TH Grahn
- TM Keane
- TP Stewart
- W McLaren
- X Wang
- Y Choi
- Y Li
- Y Xu
- Z Chen
- ZJ Cheng
- Publication venue
- Marshall Digital Scholar
- Publication date
- 01/01/2016
- Field of study
Background: The TALLYHO/Jng (TH) mouse is a polygenic model for obesity and type 2 diabetes first described in the literature in 2001. The origin of the TH strain is an outbred colony of the Theiler Original strain and mice derived from this source were selectively bred for male hyperglycemia establishing an inbred strain at The Jackson Laboratory. TH mice manifest many of the disease phenotypes observed in human obesity and type 2 diabetes.
Results: We sequenced the whole genome of TH mice maintained at Marshall University to a depth of approximately 64.8X coverage using data from three next generation sequencing runs. Genome-wide, we found approximately 4.31 million homozygous single nucleotide polymorphisms (SNPs) and 1.10 million homozygous small insertions and deletions (indels) of which 98,899 SNPs and 163,720 indels were unique to the TH strain compared to 28 previously sequenced inbred mouse strains. In order to identify potentially clinically-relevant genes, we intersected our list of SNP and indel variants with human orthologous genes in which variants were associated in GWAS studies with obesity, diabetes, and metabolic syndrome, and with genes previously shown to confer a monogenic obesity phenotype in humans, and found several candidate variants that could be functionally tested using TH mice. Further, we filtered our list of variants to those occurring in an obesity quantitative trait locus, tabw2, identified in TH mice and found a missense polymorphism in the Cidec gene and characterized this variant’s effect on protein function.
Conclusions: We generated a complete catalog of variants in TH mice using the data from whole genome sequencing. Our findings will facilitate the identification of causal variants that underlie metabolic diseases in TH mice and will enable identification of candidate susceptibility genes for complex human obesity and type 2 diabetes
Definition of Monitoring Objectives
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1999
- Field of study
Sedimentary units-layering system and depositional model of the carbonate Mishrif reservoir in Rumaila oilfield, Southern Iraq
- Author
- A Aksoy
- A Al-Siddiki
- A Nazeera
- AA Aqrawi
- AA Aqrawi
- AK Chamberlain
- AS Aisharhan
- AS Alsharhan
- DH Yaalon
- FJ Pettijohn
- FS Buchem van
- GA James
- GH Sherwani
- J Armstrong-Altrin
- J Veizer
- JK Al-Bahadily
- LK Koptíková
- MA Hlelai
- NA Siddiqui
- OJ Olatoke
- PM Harris
- R. W. SCOTT
- RJ Murris
- RM Owen
- S Lüning
- S Simone
- SM Awadh
- SM Awadh
- T Aigner
- T Buday
- TP Buchette
- WH Ferti
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Metabolomics profiles associated with HbA1c levels in patients with type 2 diabetes
- Author
- A Floegel
- A. Preet
- AP Siskos
- Bong-Jo Kim
- C Nagata
- EP Wijekoon
- F Xu
- H den Ouden
- H-S Lee
- Heun-Sik Lee
- Ho-Yeong Yu
- Hyun Jeong Jeon
- Hyung Jin Choi
- International Expert C.
- Jeong-Min Kim
- JK Nicholson
- JR Bain
- Jun Ho Yun
- K Natarajan Sulochana
- LM t Hart
- M Cruz
- N Safai
- R Wang-Sattler
- RJ Koenig
- RV Sekhar
- S Cheng
- S Deja
- SI Sherwani
- T Suvitaival
- Taekeun Oh
- Tatsuo Shimosawa
- WH Organization
- Y Qiu
- Yeon-Jung Kim
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Formation of intracellular lumina in human prostate carcinoma (DU145) cells, maturation into signet cells, and the cribriform morphology of tumors
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- A Betz
- A Durmayaz
- A Faaij
- A Franco
- A Hasan
- A Hepbasli
- A Hepbasli
- A Oo
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- A Piatti
- A Ucar
- A Uslu
- A Zhivov
- AF Sherwani
- AS Joshi
- B Bøhm
- B Chatterjee
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- B Skagestad
- BV Mathiesen
- C Coskun
- C Gabrielii
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- C Weber
- CM Looney
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- D Jager de
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- E Nieuwlaar
- E Pulat
- ENeRGI STYRELSEN
- Energy Efficiency Office
- EV Laursen
- F Heberle
- G Chicco
- GC Young
- GM Masters
- H Gunerhan
- H Lund
- H Lund
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- H Rogner
- Hİ Tol
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- MA Rosen
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- NRCAN
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- P Ahmadi
- P Dalin
- P Elsman
- P Hearps
- P Lako
- PA Østergaard
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- PG Charalambous
- PJ Mago
- R DiPippo
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- S Dubey
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- The International Renewable Energy Agency (IRENA)
- The Mathworks Inc
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- TW Patzek
- VD Baxter
- Vela Solaris AG
- Y Huang
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- Publication venue
- Taylor & Francis
- Publication date
- 01/01/2015
- Field of study
Cytosine hydroxymethylation by TET enzymes: From the control of gene expression to the regulation of DNA repair mechanisms, and back
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- Publication venue
- 'American Institute of Mathematical Sciences (AIMS)'
- Publication date
- 01/01/2018
- Field of study
Relationship between hemoglobin A1c and serum troponin in patients with diabetes and cardiovascular events
- Author
- A Abedini
- A Aneja
- A Chawla
- A Kohlgruber
- A Kumar
- A Moskowitz
- A Pazin-Filho
- A Tripodi
- A Tripodi
- AHB Wu
- AHB Wu
- AHB Wu
- AL Rasmussen
- American Diabetes Association
- American Diabetes Association
- Aminu K. Bello
- B Fure
- BA Lemkes
- BC Astor
- C Cavallini
- C Hjalmarsson
- CAW Segre
- CB Christiansen
- CM Bennett
- D Aguilar
- D Grembowski
- E Lachmandas
- EB Ketema
- ECHJ Michielsen
- ED Michos
- EI Ammal
- EJ Bell
- Elizabeth Selvin
- F Bessière
- G Agarwal
- G Biesenbach
- G Goderis
- G Güder
- G Lerstad
- G-C Zhong
- GA Nichols
- Group TAC
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- GS Tomova
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- H Ekmekci
- H Ma
- H Yokoyama
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- HW Rodbard
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- I Gornik
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- IA Katrukha
- IM Evers
- J Fang
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- J Kawano
- J Mair
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Carica papaya: comprehensive overview of the nutritional values, phytochemicals and pharmacological activities
- Author
- A Adebiyi
- A Adebiyi
- A Ademe
- A Adesuyi
- A Agarwal
- A Bashir
- A Chauhan
- A Emeruwa
- A Gbolade
- A Gupta
- A Islam
- A Mansurah
- A Mohammed
- A Nakatsuma
- A Nariya
- A Nugroho
- A Omonkhua
- A Ortega-pacheco
- A Priyadarshi
- A Rahmat
- A Rockinger
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- A Singhai
- A Umar
- AA Adeneye
- AA Asadullah
- AA El-nekeety
- AA Mustapha
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- Publication venue
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- Publication date
- Field of study
RSSDI-ESI Clinical Practice Recommendations for the Management of Type 2 Diabetes Mellitus 2020
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- A Basu
- A Belfiore
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- A Cahn
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- A Chawla
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- A Gaddam
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- A Jabbar
- A Kanungo
- A Keech
- A Krishnan
- A Lee
- A Macchia
- A Markham
- A Misra
- A Misra
- A Misra
- A Misra
- A Misra
- A Misra
- A Misra
- A Misra
- A Misra
- A Misra
- A Misra
- A Norhammar
- A Norouzy
- A Pandey
- A Pareek
- A Patel
- A Persynaki
- A Pimazoni-Netto
- A Qaseem
- A Ramachandran
- A Ramachandran
- A Ramachandran
- A Ramachandran
- A Ramachandran
- A Ramachandran
- A Ramachandran
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- A Ramachandran
- A Ramachandran
- A Ramachandran
- A Ramachandran
- A Ramachandran
- A Ramachandran
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- A Steptoe
- A Thampy
- A Tufano
- A Varghese
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- AB Goldfine
- AC Mathew
- AC Sylvetsky
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- ACOG Practice Bulletin No. 201
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- AE Kitabchi
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- AM Egan
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- American Diabetes A
- American Diabetes A
- American Diabetes A
- American Diabetes A
- American Diabetes A. 14
- American Diabetes A. 15
- American Diabetes A. 8
- American Diabetes Association
- American Diabetes Association. 1
- American Diabetes Association. 2
- American Diabetes Association. 4
- American Diabetes Association. 7
- American Diabetes Association. 8
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- DD Pratyush
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- DECODA Study Group
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- Diabetes Control and Complications Trial Research Group
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