11 research outputs found
Contribution of magnetic resonance imaging in the diagnosis of talus skip metastases of Ewing's sarcoma of the calcaneus in a child: a case report
<p>Abstract</p> <p>Introduction</p> <p>Ewing's sarcoma of the calcaneus is rare. About thirty cases with calcaneus involvement have been reported in the literature. Talus skip metastases have rarely been described in the available literature</p> <p>Case presentation</p> <p>We report a case of a 14-year-old Moroccan boy, who presented with Ewing's sarcoma of his right calcaneus, diagnosed by swelling of the calcaneus evolving over a year. Radiography, computed tomography and magnetic resonance imaging showed an important tumoral process of the calcaneus and talus skip metastases. The diagnosis was confirmed with histology after a biopsy. In spite of amputation and postoperative chemotherapy, our patient died six months later due to secondary respiratory distress after lung metastasis.</p> <p>Conclusion</p> <p>Imaging, especially magnetic resonance, is important in the diagnosis of Ewing sarcoma and skeletal skip metastases. Treatment of Ewing's sarcoma consists of chemotherapy, radiation therapy and surgical resection depending on the stage and extent of the disease. With the exception of lesions in the calcaneus, the prognosis for disease-free survival of Ewing's sarcoma of the foot is excellent.</p
Vibrational microscopy and imaging of skin: from single cells to intact tissue
Vibrational microscopy and imaging offer several advantages for a variety of dermatological applications, ranging from studies of isolated single cells (corneocytes) to characterization of endogenous components in intact tissue. Two applications are described to illustrate the power of these techniques for skin research. First, the feasibility of tracking structural alterations in the components of individual corneocytes is demonstrated. Two solvents, DMSO and chloroform/methanol, commonly used in dermatological research, are shown to induce large reversible alterations (α-helix to ÎČ-sheet) in the secondary structure of keratin in isolated corneocytes. Second, factor analysis of image planes acquired with confocal Raman microscopy to a depth of 70 Όm in intact pigskin, demonstrates the delineation of specific skin regions. Two particular components that are difficult to identify by other means were observed in the epidermis. One small region was formed from a conformationally ordered lipid phase containing cholesterol. In addition, the presence of nucleated cells in the tissue (most likely keratinocytes) was revealed by the spectral signatures of the phosphodiester and cytosine moieties of cellular DNA
Laser induced fluorescence spectroscopy of normal and atherosclerotic human aorta using 306-310 nm excitation.
Sarcoma de Ewing: aspectos clĂnicos e radiogrĂĄficos de 226 casos Ewing's sarcoma: clinical and radiographic aspects of 226 cases
OBJETIVO: Avaliar os aspectos radiogrĂĄficos e clĂnicos presentes em pacientes com o diagnĂłstico de sarcoma de Ewing confirmado por histopatologia. MATERIAIS E MĂTODOS: Foram analisados, neste trabalho, os dados clĂnicos e radiogrĂĄficos (quando disponĂveis) de 226 pacientes com o diagnĂłstico de sarcoma de Ewing Ăłsseo. RESULTADOS: Dos casos avaliados, 61,5% (139) eram do sexo masculino e 83,7% (189) eram brancos. A mediana de idade dos pacientes foi de 14 anos e a topografia mais freqĂŒente das lesĂ”es foi o osso ilĂaco, em 13,7% (31) dos casos. O aspecto radiogrĂĄfico mais comum foi o de lesĂŁo lĂtica com reação periosteal (padrĂ”es variados), em 32,7% (74) dos casos. CONCLUSĂO: O sarcoma de Ewing Ăłsseo Ă© uma neoplasia bastante agressiva, ocorrendo mais comumente em indivĂduos na segunda dĂ©cada de vida e cujo aspecto radiogrĂĄfico mais comum Ă© o de lesĂŁo lĂtica com reação periosteal tĂpica de lesĂŁo agressiva.<br>OBJECTIVE: To review the clinical and radiographic findings in patients with histologically confirmed Ewing's sarcoma. MATERIALS AND METHODS: Clinical and radiological (whenever available) data of 226 patients with Ewing's sarcoma of the bone were analyzed. RESULTS: Of the evaluated cases, 61.5% (139) were male and 83.7% (189) were white. The average age was 14 years old and the most common site of the lesions was the iliac bone, seen in 13.7% (31) of the cases. The most common radiological findings were lytic lesion with periosteal reaction, seen in 32.7% (74) of the patients. CONCLUSION: Ewing's sarcoma of bone is an aggressive neoplasm, occurring mainly in the second decade of life, which main radiological findings are lytic lesions with periosteal reaction, typical characteristic of aggressive lesions