Health‑related quality of life in patients newly diagnosed with prostate cancer: CAPLIFE study

Funding Funding for open access charge: Universidad de Granada / CBUA. This research was funded by Regional Ministry of Health and Families of Andalusia/Consejería de Salud y Familias de la Junta de Andalucía (PI-0514-2016).Purpose To analyse the Health-Related Quality of Life (HRQoL) at diagnosis of patients with prostate cancer (PCa) according to tumour extension and urinary symptomatology and to explore factors associated with HRQoL. Methods 408 Controls and 463 PCa cases were included. Eligibility criteria were a new diagnosis of PCa (cases), 40–80 years of age, and residence in the participating hospitals’ coverage area for ≥ 6 months before recruitment. HRQoL was evaluated using the 12-Item Short-Form Health Survey, Mental (MCS) and Physical Component Summaries (PCS), and urinary symptoms with the International Prostate Symptom Score. HRQoL scores for all PCa cases, according to tumour extension and urinary symptoms, were compared with controls. In addition, information about lifestyles and comorbidities was collected and its association with low HRQoL (lower scores) were explored using logistic regression models. Results Overall cases had similar PCS score, but lower MCS score than controls. The lowest standardised scores for both PCS and MCS were reached by cases with severe urinary symptoms and a metastatic tumour [mean (SD); PCS: 41.9 (11.5), MCS: 42.3 (10.3)]. Having “below” PCS and MCS scores was associated with the presence of three or more comorbidities in the cases [aOR = 2.86 (1.19–6.84) for PCS and aOR = 3.58 (1.37–9.31) for MCS] and with severe urinary symptomatology [aOR = 4.71 (1.84–12.08) for PCS and aOR = 7.63 (2.70–21.58) for MCS]. Conclusion The mental dimension of HRQoL at diagnosis of patients with PCa was lower than in controls, especially for cases with severe urinary symptoms and a metastatic tumour. Comorbidities and urinary symptoms were variables associated with the HRQoL of PCa cases.Funding for open access charge: Universidad de Granada/CBUARegional Ministry of Health and Families of Andalusia/Consejería de Salud y Familias de la Junta de Andalucía (PI-0514-2016

Effectiveness of an intervention for improving drug prescription in primary care patients with multimorbidity and polypharmacy:Study protocol of a cluster randomized clinical trial (Multi-PAP project)

This study was funded by the Fondo de Investigaciones Sanitarias ISCIII (Grant Numbers PI15/00276, PI15/00572, PI15/00996), REDISSEC (Project Numbers RD12/0001/0012, RD16/0001/0005), and the European Regional Development Fund ("A way to build Europe").Background: Multimorbidity is associated with negative effects both on people's health and on healthcare systems. A key problem linked to multimorbidity is polypharmacy, which in turn is associated with increased risk of partly preventable adverse effects, including mortality. The Ariadne principles describe a model of care based on a thorough assessment of diseases, treatments (and potential interactions), clinical status, context and preferences of patients with multimorbidity, with the aim of prioritizing and sharing realistic treatment goals that guide an individualized management. The aim of this study is to evaluate the effectiveness of a complex intervention that implements the Ariadne principles in a population of young-old patients with multimorbidity and polypharmacy. The intervention seeks to improve the appropriateness of prescribing in primary care (PC), as measured by the medication appropriateness index (MAI) score at 6 and 12months, as compared with usual care. Methods/Design: Design:pragmatic cluster randomized clinical trial. Unit of randomization: family physician (FP). Unit of analysis: patient. Scope: PC health centres in three autonomous communities: Aragon, Madrid, and Andalusia (Spain). Population: patients aged 65-74years with multimorbidity (≥3 chronic diseases) and polypharmacy (≥5 drugs prescribed in ≥3months). Sample size: n=400 (200 per study arm). Intervention: complex intervention based on the implementation of the Ariadne principles with two components: (1) FP training and (2) FP-patient interview. Outcomes: MAI score, health services use, quality of life (Euroqol 5D-5L), pharmacotherapy and adherence to treatment (Morisky-Green, Haynes-Sackett), and clinical and socio-demographic variables. Statistical analysis: primary outcome is the difference in MAI score between T0 and T1 and corresponding 95% confidence interval. Adjustment for confounding factors will be performed by multilevel analysis. All analyses will be carried out in accordance with the intention-to-treat principle. Discussion: It is essential to provide evidence concerning interventions on PC patients with polypharmacy and multimorbidity, conducted in the context of routine clinical practice, and involving young-old patients with significant potential for preventing negative health outcomes. Trial registration: Clinicaltrials.gov, NCT02866799Publisher PDFPeer reviewe

SEGURANÇA SEM FRONTEIRAS, SEGURANÇA EM ABSTRACTO? TENDÊNCIAS NO ESTUDO DA CIBER-SEGURANÇA E DA CIBERDEFESA

While digital technology brings significant economic and social benefits to much of the population, issues such as unequal access to the Internet, the lack of a global system of technology governance and cyber insecurity pose a significant risk to international security. The lack of global technology governance and the presence of cyber security blind spots increase the risk of fragmented cyberspace and competing technology regulations. All this leads us to say that we live in a world without borders in terms of cybersecurity. Because of this alarming situation, we will try to identify the main cybersecurity challenges, which represent an alarming risk to international peace and security. First, we will address the threat posed by cyberattacks, cyber privacy, cybercrime and cyberwar. We will then move on to systemic risk and resilience, the “security of things” and critical infrastructure protection. Finally, we will analyze the new rules of collaboration and the implications of cybersecurity issues in international law. All of this will be done taking into account the actual international political situation.Si bien la tecnología digital aporta importantes beneficios económicos y sociales a gran parte de la población, cuestiones como el acceso des- igual a la Internet, la falta de un sistema mundial de gobernanza de la tecnología y la inseguridad cibernética plantean un riesgo importante para la seguridad internacional. La falta de una gobernanza tecnoló- gica mundial y la presencia de puntos ciegos de seguridad cibernética aumentan el riesgo de fragmentación del ciberespacio y de reglamen- tos tecnológicos que compiten entre sí. Todo esto nos lleva a decir que vivimos en un mundo sin fronteras en términos de ciberseguridad. De- bido a esta alarmante situación, trataremos de identificar los princi- pales desafíos de la ciberseguridad, los cuales representan un riesgo alarmante para la paz y la seguridad internacionales. En primer lugar, será abordada la amenaza que suponen los ciberataques, la ciberpri- vacidad, la ciberdelincuencia y la ciberguerra. Luego se hará énfasis en los riesgos y la resistencia sistémicos, la “seguridad de las cosas/ security of things” y la protección de las infraestructuras críticas. Final- mente, se propone un análisis de las nuevas reglas de colaboración y las implicaciones de las cuestiones de ciberseguridad en el derecho in- ternacional. Todo esto se hará teniendo en cuenta la situación política internacional;Embora a tecnologia digital traga benefícios econômicos e sociais significativos para grande parte da população, questões como o acesso desigual à Internet, a falta de um sistema global de governança tecnológica e a insegurança cibernética representam um risco significativo para a segurança internacional. A falta de governança global da tecnologia e a presença de pontos cegos de segurança cibernética aumentam o risco de fragmentação do ciberespaço e de regulamentações tecnológicas concorrentes. Tudo isso nos leva a dizer que vivemos num mundo sem fronteiras em termos de segurança cibernética. Devido a esta situação alarmante, vamos tentar identificar os principais desafios da cibersegurança, que representam um risco alarmante para a paz e segurança internacional. Primeiro, abordaremos a ameaça que representam os ataques cibernéticos, a ciberprivacidade, o crime cibernético e a guerra cibernética. Em seguida, passaremos aorisco sistêmico e à resiliência, à “segurança das coisas” e à proteção da infra-estrutura crítica. Finalmente, analisaremos as novas regras de colaboração e as implicações das questões de segurança cibernética no direito internacional. Tudo isso será feito levando em conta a situação política internacional

Informalidad laboral en el centro de la ciudad de Sincelejo – Sucre – Colombia /

1.5 MB : 105 páginas ; figuras, graficasEl objetivo de esta investigación es analizar los determinantes que influyen en los trabajadores informales estacionarios en el centro de la ciudad de Sincelejo – Sucre. Este estudio se enfoca desde varias teorías como la estructuralista, institucionalista y la general con el fin de conocer cada pensamiento en relación a la informalidad laboral. La investigación es de diseño no experimental, de campo, de corte transversal, de nivel exploratorio y explicativo, el estudio se abordó desde un enfoque cuantitativo, la población fue de 298.836 personas con una muestra representativa de 120, que corresponde al 47,20% perteneciente al sector comercio. La técnica de recolección de datos fue una encuesta, que próximamente se aplicara a través de un cuestionario con 56 ítems para así dar a conocer su respectivo análisis de resultados. El trabajo.The objective of this research is to analyze the determinants that influence stationary informal workers in the center of the city of Sincelejo - Sucre. This study is approached from several theories such as structuralist, institutionalist and general in order to know each thought in relation to labor informality. The research is of non-experimental design, field, cross-sectional, exploratory and explanatory level, the study was approached from a quantitative approach, the population was 298.836 people with a representative sample of 120, which corresponds to 47.20% belonging to the commerce sector. The data collection technique was a survey, which will soon be applied through a questionnaire with 56 items in order to present the respective analysis of the results. El trabajo.PregradoEconomistaTrabajo de grado(Economista) --Corporación Universitaria del Caribe – CECAR. Facultad de Ciencias Económicas y Administrativas FACEA Programa de Economía Sincelejo-Sucre, 2020

Informalidad laboral en el centro de la ciudad de Sincelejo - Sucre - Colombia /

1.5 MB : 105 páginas ; gráficasEl objetivo de esta investigación es analizar los determinantes que influyen en los trabajadores informales estacionarios en el centro de la ciudad de Sincelejo – Sucre. Este estudio se enfoca desde varias teorías como la estructuralista, institucionalista y la general con el fin de conocer cada pensamiento en relación a la informalidad laboral. La investigación es de diseño no experimental, de campo, de corte transversal, de nivel exploratorio y explicativo, el estudio se abordó desde un enfoque cuantitativo, la población fue de 298.836 personas con una muestra representativa de 120, que corresponde al 47,20% perteneciente al sector comercio. La técnica de recolección de datos fue una encuesta, que próximamente se aplicara a través de un cuestionario con 56 ítems para así dar a conocer su respectivo análisis de resultados. El trabajo.The objective of this research is to analyze the determinants that influence stationary informal workers in the center of the city of Sincelejo - Sucre. This study is approached from several theories such as structuralist, institutionalist and general in order to know each thought in relation to labor informality. The research is of non-experimental design, field, cross-sectional, exploratory and explanatory level, the study was approached from a quantitative approach, the population was 298.836 people with a representative sample of 120, which corresponds to 47.20% belonging to the commerce sector. The data collection technique was a survey, which will soon be applied through a questionnaire with 56 items in order to present the respective analysis of the results. El trabajo.PregradoEconomistaTrabajo de grado(Economista) --Corporación Universitaria del Caribe. Facultad de Ciencias Económicas y Administrativas. Programa de Economía. Sincelejo, 2020

El internacionalista y sus aportaciones en la construcción de la agenda II

En este reporte PAP se abordan los objetivos y los resultados del Proyecto "Agenda Global: Comunicación y Periodismo" durante el periodo de otoño 2015. El proyecto tuvo como objetivo principal brindar y fortalecer a medios alternativos de comunicación de la Zona Metropolitana de Guadalajara (ZMG) y de la región del Sur de Jalisco en cuanto a temas de análisis y coyuntura internacional a través de la producción de notas y crónicas informativos desde una perspectiva internacionalista

Microbial Profile of the Leachate from Mexico City’s Bordo Poniente Composting Plant: An Inoculum to Digest Organic Waste

In recent years, municipal solid waste (MSW) management has become a complex problem worldwide. Similarly, Mexico City is facing such a situation for the management and treatment of organic fraction of municipal solid waste (OFMSW). Therefore, in this work, we investigated whether leachate from the composting plant, Bordo Poniente, located in Mexico City can be used as an inoculum for the treatment of OFMSW using thermophilic anaerobic digestion (AD) with a hydraulic retention time of 30 days. We analyzed the physicochemical properties of the leachate and performed a biochemical methane potential test. Archaeal and bacterial diversity was also identified using high throughput DNA sequencing of 16S rDNA libraries. Methane yield was 0.29 m3 CH4/kg VSadded in the positive control and 0.16 m3 CH4/kg VSadded in the treatment group. The phylum, Bacteroidetes, and genus, Methanosarcina, prevailed in the leachate. However, in thermophilic conditions, the microbial communities changed, and the phylum, Firmicutes, genera, Methanoculleus, and candidate genus, vadinCA11, were dominant in the treatment group. We concluded that the leachate contains a suitable initial charge of many active bacteria and methanogenic archaea which contribute to the AD process, hence it can be used as an inoculum for the treatment of OFMSW

Enriched mesoporous bioactive glass scaffolds as bone substitutes in critical diaphyseal bone defects in rabbits

In the field of orthopedic surgery, there is an increasing need for the development of bone replacement materials for the treatment of bone defects. One of the main focuses of biomaterials engineering are ad- vanced bioceramics like mesoporous bioactive glasses (MBG´s). The present study compared the new bone formation after 12 weeks of implantation of MBG scaffolds with composition 82,5SiO2 –10CaO–5P2 O5 - x 2.5SrO alone (MBGA), enriched with osteostatin, an osteoinductive peptide, (MBGO) or enriched with bone marrow aspirate (MBGB) in a long bone critical defect in radius bone of adult New Zealand rab- bits. New bone formation from the MBG scaffold groups was compared to the gold standard defect filled with iliac crest autograft and to the unfilled defect. Radiographic follow-up was performed at 2, 6, and 12 weeks, and microCT and histologic examination were performed at 12 weeks. X-Ray study showed the highest bone formation scores in the group with the defect filled with autograft, followed by the MBGB group, in addition, the microCT study showed that bone within defect scores (BV/TV) were higher in the MBGO group. This difference could be explained by the higher density of newly formed bone in the os- teostatin enriched MBG scaffold group. Therefore, MBG scaffold alone and enriched with osteostatin or bone marrow aspirate increase bone formation compared to defect unfilled, being higher in the osteo- statin group. The present results showed the potential to treat critical bone defects by combining MBGs with osteogenic peptides such as osteostatin, with good prospects for translation into clinical practice.Instituto de Salud Carlos IIIEuropean Commission-ERCDepto. de Química en Ciencias FarmacéuticasFac. de FarmaciaTRUEpu