Orbital Magneto-Nonlinear Anomalous Hall Effect in Kagome Magnet Fe3_3Sn2_2

It has been theoretically predicted that perturbation of the Berry curvature by electromagnetic fields gives rise to intrinsic nonlinear anomalous Hall effects that are independent of scattering. Two types of nonlinear anomalous Hall effects are expected. The electric nonlinear Hall effect has recently begun to receive attention, while very few studies are concerned with the magneto-nonlinear Hall effect. Here, we combine experiment and first-principles calculations to show that the kagome ferromagnet Fe$_3$Sn$_2$ displays such a magneto-nonlinear Hall effect. By systematic field angular and temperature-dependent transport measurements, we unambiguously identify a large anomalous Hall current that is linear in both applied in-plane electric and magnetic fields, utilizing a unique in-plane configuration. We clarify its dominant orbital origin and connect it to the magneto-nonlinear Hall effect. The effect is governed by the intrinsic quantum geometric properties of Bloch electrons. Our results demonstrate the significance of the quantum geometry of electron wave functions from the orbital degree of freedom and open up a new direction in Hall transport effects.Comment: 18 pages, 4 figures, featured in Physics: Viewpoint and Editors' suggestion

Asymmetric Fraunhofer pattern in Josephson junctions from inversion symmetry broken V5_5S8_8

Introduction of spin orbit coupling (SOC) in a Josephson junction (JJ) gives rise to unusual Josephson effects. We investigate JJs based on a newly discovered heterodimensional superlattice V$_5$S$_8$ with broken inversion symmetry and a special form of SOC. The unique homointerface of our JJs enables elimination of extrinsic effects due to interfaces and disorder. We observe asymmetric Fraunhofer patterns with respect to both the perpendicular magnetic field and the current. The asymmetry is influenced by an in-plane magnetic field. Analysis of the pattern points to a nontrivial spatial distribution of the Josephson current that is intrinsic to the SOC in V$_5$S$_8$.Comment: 16 pages,5 figure

Mechanisms of hyponatremia in patients with decompensated liver cirrhosis treated with terlipressin and related treatment principles

Esophagogastric variceal bleeding and hepatorenal syndrome are common complications in patients with decompensated liver cirrhosis and portal hypertension. Terlipressin can lead to the constriction of visceral vessels, reduce portal venous pressure, and increase renal perfusion and is the first-line drug. In recent years, it has been reported that some patients experienced hyponatremia during the treatment with terlipressin. Since patients with liver cirrhosis tend to develop hyponatremia, the application of terlipressin may have an adverse effect on the management of serum sodium level in such patients. This article summarizes the incidence rate of hyponatremia during terlipressin treatment and related risk factors and introduces the pathogenesis of hyponatremia during terlipressin treatment in patients with decompensated liver cirrhosis and the treatment principles for hyponatremia. If the occurrence of hyponatremia can be controlled, terlipressin may be an effective drug for the treatment of portal hypertension

Antiviral therapy for hepatitis virus-related hepatocellular carcinoma: current status and challenges

The incidence rate of hepatocellular carcinoma (HCC) is increasing around the world and tends to decrease in East Asia and several regions in China; however, China still has higher incidence rate and mortality rate of HCC than most countries. Studies have shown that long-term antiviral therapy can inhibit HBV replication to a very low level or help patients with HCV infection achieve sustained virologic response, which can further reduce the incidence rate of virus-related HCC. New evidence suggests that compared with nucleos(t)ide analogues, PEG-IFNα has a better effect of secondary prevention. Studies also indicate that interferons play an important role in tertiary prevention of virus-related HCC. This article reviews the epidemiological studies on virus-related HCC in recent years and the role of antiviral therapy in second and tertiary prevention and points out that adequate and effective antiviral therapy is the basis for preventing the development and recurrence of HCC

Theoretical study of lithium diffusion and fractionation in the lattice of clinoenstatite, pyrope and spinel

Clinoenstatite, pyrope and spinet, the important end members of pyroxene, garnet and spinet groups, are major mineral compositions in the upper mantle. Li isotopes are important tracer element in the mantle geochemistry, and its properties of diffusion and fractionation in the major mantle minerals are important for understanding Li isotopes as a tracer element of the mantle geochemistry. By performing the classical force field calculations at the atomic scale, we calculated the activation energies of the Li diffusion in the clinoenstatite, pyrope and spinet lattice via both interstitial and substitution mechanisms under the different pressures and temperatures; meanwhile, we have also calculated the effect of Li isotopes fractionations on various mineral lattice sites. The results suggest that the Li isotopes are migrating through the substitution mechanism in the clinoenstatite, pyrope and spinet lattice. The fractionation calculation of Li isotopes on the different lattice sites indicate that Li-7 is more likely incorporate on the interstitial sites while Li-6 prefers to move into Mg vacancies. The temperature is one of the key factors affecting the fractionation, and the corresponding results can be used to explain scientific issues such as Li isotopic composition in the mantle and the isotopic fractionation under the cooling conditions

Enhancing recommendation acceptance:Resolving the personalization–privacy paradox in recommender systems: A privacy calculus perspective

The concept of recommendation acceptance intention (RAI) refers to the willingness of an individual to adopt and use recommender systems. However, contemporary recommender systems, relying solely on accuracy as an evaluation metric have demonstrated subpar performance. The evolving landscape requires the integration of multiple objectives, including relevance, diversity, novelty, and coverage. This study investigates the influence of distinct product organization formats (similar vs. related products) on consumer reactions, aiming to reduce privacy concerns while achieving objectives such as relevance and variety. Grounded in the privacy calculus theory and personalization–privacy paradox framework, this study asserts that organization formats prompt consumers to evaluate a recommender system, considering both privacy risks and personalization benefits. Findings from three experiments and one qualitative study indicate that a related product organization format effectively decreases consumer perceptions of privacy violation while enhancing their perceptions of variety compared to a similar product organization format. This result contributes to RAI and shapes consumer preferences for recommender systems. Moreover, this research distinguishes the mechanisms underlying the influence of organization formats on RAI in the context of different product types, such as durable goods and consumables. This distinction enhances implications for designing recommender systems in e-commerce.</p

Enhancing recommendation acceptance:Resolving the personalization–privacy paradox in recommender systems: A privacy calculus perspective

The concept of recommendation acceptance intention (RAI) refers to the willingness of an individual to adopt and use recommender systems. However, contemporary recommender systems, relying solely on accuracy as an evaluation metric have demonstrated subpar performance. The evolving landscape requires the integration of multiple objectives, including relevance, diversity, novelty, and coverage. This study investigates the influence of distinct product organization formats (similar vs. related products) on consumer reactions, aiming to reduce privacy concerns while achieving objectives such as relevance and variety. Grounded in the privacy calculus theory and personalization–privacy paradox framework, this study asserts that organization formats prompt consumers to evaluate a recommender system, considering both privacy risks and personalization benefits. Findings from three experiments and one qualitative study indicate that a related product organization format effectively decreases consumer perceptions of privacy violation while enhancing their perceptions of variety compared to a similar product organization format. This result contributes to RAI and shapes consumer preferences for recommender systems. Moreover, this research distinguishes the mechanisms underlying the influence of organization formats on RAI in the context of different product types, such as durable goods and consumables. This distinction enhances implications for designing recommender systems in e-commerce.</p

Carcinogenèse hépatique et virus de l’hépatite C

Le rôle du virus de l’hépatite C dans la survenue du carcinome hépatocellulaire est évident d’un point de vue épidémiologique, mais les mécanismes de cette carcinogenèse restent obscurs. Lors de l’infection par ce virus, le carcinome hépatocellulaire ne survient que rarement en l’absence de cirrhose et pratiquement jamais sur un foie normal. Contrairement à celui du virus de l’hépatite B, le pouvoir oncogénique du VHC semble plus limité. Néanmoins, de nombreuses interactions entre les protéines virales et cellulaires ont été décrites et pourraient être impliquées à la fois dans la carcinogenèse et dans la persistance virale. Les modèles de souris transgéniques et les approches récentes utilisant le transcriptome et le protéome pourraient aider à la compréhension de ce cancer fréquent et difficile à traiter

A New Positioning Strategy Based on Parameter Tuning and Optimal Control Technique for Pneumatic Control Valve

To improve the accuracy, rapidity, and versatility of pneumatic control valves, mechanism modeling, and optimization analysis on pneumatic actuators were carried out, and then a new positioning strategy based on parameter tuning and optimal control technique was proposed consequently. Firstly, a dynamic model of valve position based on optimal control under constraint conditions was established, and the characteristic parameters of valve position motion were determined. Then, the adaptive processing of switching points was introduced into the optimal control strategy to improve the versatility of the control. Finally, according to different control strategy partitions, the interactive control of the piezoelectric air switch by fully open control and PWM improves the control accuracy of the algorithm. The experimental analysis of the control effect with other brand positioners shows that the proposed control strategy shortens the system adjustment time, improves the accuracy of valve position, and avoids the overshoot

BRANT: A Versatile and Extendable Resting-State fMRI Toolkit

Data processing toolboxes for resting-state functional MRI (rs-fMRI) have provided us with a variety of functions and user friendly graphic user interfaces (GUIs). However, many toolboxes only cover a certain range of functions, and use exclusively designed GUIs. To facilitate data processing and alleviate the burden of manually drawing GUIs, we have developed a versatile and extendable MATLAB-based toolbox, BRANT (BRAinNetome fmri Toolkit), with a wide range of rs-fMRI data processing functions and code-generated GUIs. During the implementation, we have also empowered the toolbox with parallel computing techniques, efficient file handling methods for compressed file format, and one-line scripting. In BRANT, users can find rs-fMRI batch processing functions for preprocessing, brain spontaneous activity analysis, functional connectivity analysis, complex network analysis, statistical analysis, and results visualization, while developers can quickly publish scripts with code-generated GUIs