23 research outputs found
The impact of a standardized order set for the management of non-hip fragility fractures in a Fracture Liaison Service
Swallowing disturbance due to isolated vagus nerve involvement in systemic lupus erythematosus
Public Awareness and Knowledge of Prostate Cancer in Japan: Results of a Survey at Short-Stay Examination Facilities
Dry Eye and its Relationship with Status of Serum Calcium in the Body at a Tertiary Care Institute: A Case Control Study
The Comparative effects of Transdermal and Intramuscular Diclofenac for postoperative analgesia in patients undergoing laparoscopic cholecystectomy
Knowledge and Use of, and Attitudes toward, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) in Practice: A Survey of Ontario Physiotherapists
Cranial nerve VI palsy as a rare initial presentation of systemic lupus erythematosus: case report and review of the literature
Evaluation of Glycofurol-Based Gel as a New Vehicle for Topical Application of Naproxen
In view of the good skin tolerability, glycofurol was used as a vehicle-based gel, and its effect in the topical penetration of Naproxen (NAP) was investigated. The aims of this study were to develop a suitable gel with bioadhesive property, spreadability, and viscosity for topical anti-inflammatory effect. Three gelling and adhesive agents were examined: Carbopol 974P, Gantrez AN 119, and polyvinylpyrollidone K30. Skin permeation rates and lag times of NAP were evaluated using the Franz-type diffusion cell in order to optimize the gel formulation. The permeation rate of NAP-based gel across the excised rat skin was investigated. A significant increase in permeability parameters such as steady-state flux (Jss), permeability coefficient (Kp), and penetration index (PI) was observed in optimized formulation containing 2% Transcutol as an permeation enhancer. From skin irritation test, it was concluded that the optimized novel glycofurol-based gel formulation was safe to be used for topical drug delivery. The developed glycofurol-based gel appeared promising for dermal and transdermal delivery of naproxen and could be applicable with water-insoluble drugs, which would circumvent most of the problems associated with drug therapy