35 research outputs found
Systems biological and mechanistic modelling of radiation-induced cancer
- Author
- A Dewanji
- AG Knudson Jr
- AL Jackson
- CA Reznikoff
- D. C. Thomas
- DI Portess
- DL Stoler
- DV Conti
- EC Friedberg
- ED Lancy
- EG Luebeck
- EG Luebeck
- EG Luebeck
- EI Azzam
- GE Degnen
- H Schöllnberger
- H Schöllnberger
- H. Schöllnberger
- HM Inskip
- I Tomlinson
- JC Kaiser
- JH Mao
- JL Bernstein
- JL Redpath
- JL Redpath
- LA Loeb
- LA Loeb
- M Swift
- M Swift
- M. P. Little
- MA Nowak
- MP Little
- MP Little
- MP Little
- R Meza
- RA Gatenby
- RA Gatti
- REJ Mitchel
- REJ Mitchel
- REJ Mitchel
- REJ Mitchel
- REJ Mitchel
- REJ Mitchel
- S. H. Moolgavkar
- SA Frank
- SH Moolgavkar
- SH Moolgavkar
- SH Moolgavkar
- SH Moolgavkar
- SH Moolgavkar
- W. F. Heidenreich
- WD Hazelton
- WF Heidenreich
- WF Heidenreich
- WF Heidenreich
- WF Heidenreich
- WF Heidenreich
- WF Heidenreich
- WF Heidenreich
- WF Heidenreich
- WF Heidenreich
- WF Heidenreich
- WF Heidenreich
- WF Morgan
- WF Morgan
- Publication venue
- Springer-Verlag
- Publication date
- 01/01/2007
- Field of study
This paper summarises the five presentations at the First International Workshop on Systems Radiation Biology that were concerned with mechanistic models for carcinogenesis. The mathematical description of various hypotheses about the carcinogenic process, and its comparison with available data is an example of systems biology. It promises better understanding of effects at the whole body level based on properties of cells and signalling mechanisms between them. Of these five presentations, three dealt with multistage carcinogenesis within the framework of stochastic multistage clonal expansion models, another presented a deterministic multistage model incorporating chromosomal aberrations and neoplastic transformation, and the last presented a model of DNA double-strand break repair pathways for second breast cancers following radiation therapy
Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease
- Author
- Aaltonen M
- Abdur Rahman M
- Abell T
- Abide W. Jr
- Acheatel R
- Achiri P
- Acon J
- Adams T
- Affinito S
- Agarwal S
- Aggarwal K
- Aggarwal R
- Ahlström P
- Ahmad A
- Ahmed M
- Aillon C
- Airaksinen A
- Ait-sadi R
- Akers J
- Al-jumaily J
- Albers C
- Albert M
- Alberti A
- Alexander T
- Alford C
- Algotsson L
- Allen T
- Allworth M
- Almond E
- Aloisi A
- Alternburg C
- Alton M
- Amin J
- Amundson A
- Andersen K
- Andersen M
- Anderson E
- Anderson G
- Anderson R
- Anderson T
- Andersson H
- Andersson L
- Andreo J
- Andres C
- Andresen D
- Andrews G
- Andrews L
- Andrews R
- Andrioli V
- Angermann Ce
- Annas T
- Ansell V
- Antonio-drabek C
- Antonishen D
- Antonishen M
- Anuschek V
- Appel Kf
- Appel S
- Appleyard D
- Archer A
- Armitage J
- Armstrong L
- Armstrong M
- Arnesson K
- Arnold M
- Arora P
- Arp H
- Asbill B
- Ashbrook-raby C
- Ashton L
- Assarsson E
- Audet K
- Augenbraun C
- Aung HNIN THANDA
- Auscher S
- Ausner J
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- Awasty V
- Axelsson U
- Ayers S
- Ayub H
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- Baigent C
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- Baker S
- Baldin Mg
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- Banerjee S
- Bang Hansen M
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- Barkley-daughtry S
- Barnes D
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- Zuchelkowski A
- Zulauf N
- Ågårdh A
- Öner A
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
BACKGROUND:
Patients with atherosclerotic vascular disease remain at high risk for cardiovascular events despite effective statin-based treatment of low-density lipoprotein (LDL) cholesterol levels. The inhibition of cholesteryl ester transfer protein (CETP) by anacetrapib reduces LDL cholesterol levels and increases high-density lipoprotein (HDL) cholesterol levels. However, trials of other CETP inhibitors have shown neutral or adverse effects on cardiovascular outcomes.
METHODS:
We conducted a randomized, double-blind, placebo-controlled trial involving 30,449 adults with atherosclerotic vascular disease who were receiving intensive atorvastatin therapy and who had a mean LDL cholesterol level of 61 mg per deciliter (1.58 mmol per liter), a mean non-HDL cholesterol level of 92 mg per deciliter (2.38 mmol per liter), and a mean HDL cholesterol level of 40 mg per deciliter (1.03 mmol per liter). The patients were assigned to receive either 100 mg of anacetrapib once daily (15,225 patients) or matching placebo (15,224 patients). The primary outcome was the first major coronary event, a composite of coronary death, myocardial infarction, or coronary revascularization.
RESULTS:
During the median follow-up period of 4.1 years, the primary outcome occurred in significantly fewer patients in the anacetrapib group than in the placebo group (1640 of 15,225 patients [10.8%] vs. 1803 of 15,224 patients [11.8%]; rate ratio, 0.91; 95% confidence interval, 0.85 to 0.97; P=0.004). The relative difference in risk was similar across multiple prespecified subgroups. At the trial midpoint, the mean level of HDL cholesterol was higher by 43 mg per deciliter (1.12 mmol per liter) in the anacetrapib group than in the placebo group (a relative difference of 104%), and the mean level of non-HDL cholesterol was lower by 17 mg per deciliter (0.44 mmol per liter), a relative difference of -18%. There were no significant between-group differences in the risk of death, cancer, or other serious adverse events.
CONCLUSIONS:
Among patients with atherosclerotic vascular disease who were receiving intensive statin therapy, the use of anacetrapib resulted in a lower incidence of major coronary events than the use of placebo. (Funded by Merck and others; Current Controlled Trials number, ISRCTN48678192 ; ClinicalTrials.gov number, NCT01252953 ; and EudraCT number, 2010-023467-18 .)
A comparison of the responses of tropical and temperate flies (Diptera: Sarcophagidae) to cold and heat stress
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
8-Azaguanine
- Author
- AC Hollinshead
- B Szepesi
- B Szepesi
- C Levinthal
- D Grunberger
- D Grunberger
- D Grunberger
- D Grunberger
- D Grunberger
- D Grunberger
- D Grunberger
- DH Levin
- DH Levin
- DH Levin
- DH Levin
- DH Levin
- DP Stahly
- E Hirschberg
- E Otaka
- E Otaka
- EF Zimmerman
- EF Zimmerman
- EF Zimmerman
- EHY Chu
- ER Peterson
- GP Kelle
- GW Kidder
- GW Kidder
- GW Kidder
- H Chantrenne
- H Chantrenne
- H Chantrenne
- H Chantrenne
- HG Mandel
- HG Mandel
- HG Mandel
- HG Mandel
- HR Morgan
- I Lasnitzky
- IB Levitan
- IB Levitan
- IB Weinstein
- J Morrow
- JA Nelson
- JD Davidson
- JD Smith
- JH Burchenal
- JH Mitchel Jr.
- JH Thaker
- JK Roy
- JL Way
- JL Way
- JS Youngner
- JW Littlefield
- JW Weiss
- LW Law
- M Finkelstein
- M Karon
- P Klubes
- PH Clarke
- PR Mahadevan
- REF Matthews
- REF Matthews
- RO Roblin Jr.
- RW Brockman
- RW Brockman
- SD Wainwright
- SW Kwan
- SW Kwan
- TE Webb
- WM Maclntyre
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1979
- Field of study
Serum thyroid hormones and trace element concentrations in crossbred holstein cattle naturally infected with Theileria annulata
- Author
- A Kralik
- A Meikke
- A Singh
- AA Bouman
- AE Pekary
- AK Baltaci
- AK Baltaci
- ATM Knegsel Van
- B Zietz
- Badiei Khalil
- FS Greenspan
- G Kostopanagiotou
- G Tsanadis
- Ghane Mohsen
- GI Stangl
- GJ Beckett
- GS Sandhu
- HA Tucker
- HC Freake
- JH Mitchel
- JJ Kaneko
- JR Arthur
- JR Arthur
- JT Ho
- K Aihara
- K Eder
- L Caregaro
- LMG Forsyth
- LMG Forsyth
- MD Chen
- Mehrdad Pourjafar
- Mohammadi Ebadolah
- Mostaghni Khodadad
- N Sangwan
- OH Omer
- OM Radostits
- R Col
- R Hashemi Fesharki
- RC Dickson
- S Nirmal
- SL Garg
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Smaller = Denser, and the Brain Knows It: Natural Statistics of Object Density Shape Weight Expectations
- Author
- A Chapentier
- AD Mitchel
- AM Gordon
- AM Gordon
- AM Gordon
- AM Hadjiosif
- AN Sanborn
- AR Girshick
- AR Seitz
- B Frayman
- C Crajé
- D Goldreich
- D V Cross
- G Buckingham
- G Buckingham
- G Buckingham
- G Buckingham
- HE Ross
- HW Lilliefors
- I Huang
- J Balzer
- J Brayanov
- J Fiser
- J Ross
- J Stevens
- Jesus Malo
- JH Hedges
- Jonathan Balzer
- JR Flanagan
- JR Flanagan
- JR Flanagan
- LA Baugh
- Ladan Shams
- M Grandy
- M Kawato
- M Mon-Williams
- MA Goodale
- Megan A. K. Peters
- N Anderson
- N Gekas
- O Schwartz
- P Seriès
- RC Miall
- RN Aslin
- RRH Hunt
- RS Johansson
- S Soatto
- SH Scott
- W Adams
- WS Geisler
- Y Benjamini
- Y Benjamini
- Y Weiss
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Nipple-Sparing Mastectomy for Breast Cancer and Risk-Reducing Surgery: The Memorial Sloan-Kettering Cancer Center Experience
- Author
- A Mislowsky
- AM Voltura
- Andrea Pusic
- B Gerber
- BS Freeman
- BS Freeman
- C Laronga
- CA Garcia-Etienne
- D Santini
- Deborah Capko
- EF Brachtel
- F Didier
- GR Verma
- J Luttges
- JE Rusby
- JH Rose Jr
- JJ Vyas
- John Mitchel Barry
- JP Crowe
- JY Petit
- JY Petit
- K Gulben
- KP Benediktsson
- L Eldor
- LC Hartmann
- M Morrow
- MD Lagios
- Monica Morrow
- MY Nahabedian
- Paulo de Alcantara Filho
- RL Cucin
- RS Menon
- SB Edge
- T Morimoto
- TM Tuttle
- V Sacchini
- Virgilio S. Sacchini
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Low-Dose Irradiation Affects Expression of Inflammatory Markers in the Heart of ApoE -/- Mice
- Author
- A Leinonen
- A Mertens
- A Wetzel
- A Wetzel
- A Yamanishi
- AM Abreu-Velez
- Annegret Glasow
- CC Ross
- D Hallahan
- D Hallahan
- DA Mulrooney
- Daniel Mathias
- E Corrado
- EA Miles
- F Hudon-David
- F Moriconi
- F Roedel
- FA Stewart
- G Gyenes
- G Hildebrandt
- G Hildebrandt
- G Jurisic
- G Ramirez
- GE Burch
- GG Miller
- GR Howe
- Guido Hildebrandt
- Heather Wyatt
- I Patties
- I Patties
- I Seemann
- I Seemann
- I Takahashi
- J Wang
- JE Baker
- JE Baker
- JH Miner
- JJ Gomez-Reino
- JJ Stec
- JR Stewart
- JR Stewart
- K Gabriels
- K Schubert
- KK Richter
- KS Krabbe
- KS Meir
- LF Fajardo
- LF Fajardo
- LF Fajardo
- Liwu Li
- M Boerma
- M Eghbali
- M Hauer-Jensen
- M Heckmann
- M Ieda
- M Mariyama
- M Molla
- M Van de Wouwer
- M Walther
- M Zeisberg
- Manja Kamprad
- Markus Scholz
- MH Gaugler
- MH Gaugler
- Michelle Bugden
- Mirela Barclay
- Nicholas D. Priest
- NL Weintraub
- PA Heidenreich
- PJ Lee
- PM Kern
- Q Zhou
- QS Zhou
- R Jurcut
- R Sakata
- RE Mitchel
- RE Mitchel
- RG Baluna
- Ronald E. J. Mitchel
- S Blankenberg
- S Hoving
- S Lauk
- S Lauk
- S Quarmby
- S Quarmby
- S Quarmby
- S Schultz-Hector
- SL Galper
- SM Haeryfar
- Stewart C. Whitman
- T Hayashi
- Y Ishii
- Y Matsuda
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Cognitive and behavioural concerns in epileptic children
- Author
- BFD Bourgeois
- Bullen Julie
- CB Dodrill
- CB Dodrill
- D Addy
- DA Pond
- DB Hock
- DB Smith
- EA Rodin
- EA Rodin
- Fox J Tylor
- G Marjerison
- G Stores
- JA Collins
- JA Corbett
- JH Ellenberg
- JHP Artset
- JJ Cereghino
- JR Farewell
- JS Duncon
- M Siedenberg
- Mathew CG Dikmans
- MR Chaudhary
- MR Trimble
- MR Trimble
- MR Trimble
- PJ Thompson
- PJ Thomson
- PP Singh
- R Levin
- RP Lesser
- RSA Schwab
- S Dawson
- S. K. Tamer
- Shobini L Rao
- Shobini L Rao
- Siedenberg M O’Leary
- SJ Duncan
- TA Betts
- WG Lannox
- WG Mitchel
- YJ Chen
- Ziskind E Somerfeld
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Immunohistochemical study on the distribution of neuronal nitric oxide synthase-immunoreactive neurons in the spinal cord of aged rat
- Author
- AB Malmberg
- AL Burnett
- AM Strack
- B Mayer
- BT Hyman
- CI Cha
- CI Cha
- CI Cha
- CJ Lowenstein
- CJ Woolf
- CN Honda
- Daejin Kim
- Dai-Yun Cho
- Dong Suep Sohn
- E Rubin
- HH Schmidt
- J Wood
- JA Gally
- JE Haley
- JH Lee
- JJ Mitchel
- JY Koh
- Keum Jung Lee
- Kyung Yong Kim
- L Bo
- M Nakane
- MA Hakim
- MB Hancock
- NJ Dun
- PA Bunn Jr
- RR Fiscus
- SA Lipton
- ST Meller
- Sung Su Kim
- U Förstermann
- WD Willis
- Won Bok Lee
- XY Wang
- Y Zhou
- Y Zhou
- Yoon Hee Chung
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study