23 research outputs found
Polyamide-Scorpion Cyclam Lexitropsins Selectively Bind AT-Rich DNA Independently of the Nature of the Coordinated Metal
Cyclam was attached to 1-, 2- and 3-pyrrole lexitropsins for the first time
through a synthetically facile copper-catalyzed “click” reaction.
The corresponding copper and zinc complexes were synthesized and characterized.
The ligand and its complexes bound AT-rich DNA selectively over GC-rich DNA, and
the thermodynamic profile of the binding was evaluated by isothermal titration
calorimetry. The metal, encapsulated in a scorpion azamacrocyclic complex, did
not affect the binding, which was dominated by the organic tail
Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases
The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular "reactive oxygen species" (ROSs)
can exhibit a number of biological effects, they are not of themselves
excessively reactive and thus they are not especially damaging at physiological
concentrations. However, their reactions with poorly liganded iron species can
lead to the catalytic production of the very reactive and dangerous hydroxyl
radical, which is exceptionally damaging, and a major cause of chronic
inflammation. We review the considerable and wide-ranging evidence for the
involvement of this combination of (su)peroxide and poorly liganded iron in a
large number of physiological and indeed pathological processes and
inflammatory disorders, especially those involving the progressive degradation
of cellular and organismal performance. These diseases share a great many
similarities and thus might be considered to have a common cause (i.e.
iron-catalysed free radical and especially hydroxyl radical generation). The
studies reviewed include those focused on a series of cardiovascular, metabolic
and neurological diseases, where iron can be found at the sites of plaques and
lesions, as well as studies showing the significance of iron to aging and
longevity. The effective chelation of iron by natural or synthetic ligands is
thus of major physiological (and potentially therapeutic) importance. As
systems properties, we need to recognise that physiological observables have
multiple molecular causes, and studying them in isolation leads to inconsistent
patterns of apparent causality when it is the simultaneous combination of
multiple factors that is responsible. This explains, for instance, the
decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference
Changes in the Innervation of Rabbit Craniomandibular Joint Tissues Associated with Experimental Induction of Anterior Disk Displacement: Histochemical and Immunohistochemical Studies
Determining DNA Sequence Specificity of Natural and Artificial Transcription Factors by Cognate Site Identifier Analysis
Cadherin-2 Is Required Cell Autonomously for Collective Migration of Facial Branchiomotor Neurons
Toward a sustainable theory of human trafficking and contemporary slavery
Chapter p. 21-37
This definitive reference assembles the current knowledge base on the scope and phenomena of sex trafficking as well as best practices for treatment of its survivors. A global feminist framework reflects a profound understanding of the entrenched social inequities and ongoing world events that fuel trafficking, including in its lesser-known forms. Empirically sound insights shed salient light on who buyers and traffickers are, why some survivors become victimizers, and the experiences of victim subpopulations (men, boys, refugees, sexual minorities), as well as emerging trends in prevention and protection, resilience and rehabilitation. These powerful dispatches also challenge readers to consider complex questions found at the intersections of gender, race, socioeconomic status, and politics.
https://doi.org/10.1007/978-3-319-73621-