11 research outputs found
Pathway-Based Association Analyses Identified TRAIL Pathway for Osteoporotic Fractures
Get PDF) pathway were associated with bone metabolism. This study aims to verify the potential association between hip OF and TRAIL pathway.Using genome-wide genotype data from Affymetrix 500 K SNP arrays, we performed novel pathway-based association analyses for hip OF in 700 elderly Chinese Han subjects (350 with hip OF and 350 healthy matched controls).) of the pathway had minor alleles (A) that are associated with an increased risk of hip OF, with the ORs (odds ratios) of 16.51 (95%CI:3.83–71.24) and 1.37 (95%CI:1.08–1.74), respectively.Our study supports the potential role of the TRAIL pathway in the pathogenesis of hip OF in Chinese Han population. Further functional study of this pathway will be pursued to determine the mechanism by which it confers risk to hip OF
Statistical significance approximation in local trend analysis of high-throughput time-series data using the theory of Markov chains
No full textA Four-Compartment Metabolomics Analysis of the Liver, Muscle, Serum, and Urine Response to Polytrauma with Hemorrhagic Shock following Carbohydrate Prefeed
No full textThermoelectric Properties of Cold-Pressed Higher Manganese Silicides for Waste Heat Recovery
No full textPlasma Metabolomic Profiling Suggests Early Indications for Predisposition to Latent Insulin Resistance in Children Conceived by ICSI
No full textDevelopment and validation of a physiology-based model for the prediction of pharmacokinetics/toxicokinetics in rabbits
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