Staphylococcus aureus–associated Skin and Soft Tissue Infections in Ambulatory Care

The rise in visits to outpatient and emergency departments for skin and soft tissue infections may reflect the emergence of community-associated methicillin-resistant Staphylococcus aureus

The Potential Trajectory of Carbapenem-Resistant Enterobacteriaceae, an Emerging Threat to Health-Care Facilities, and the Impact of the Centers for Disease Control and Prevention Toolkit.

Carbapenem-resistant Enterobacteriaceae (CRE), a group of pathogens resistant to most antibiotics and associated with high mortality, are a rising emerging public health threat. Current approaches to infection control and prevention have not been adequate to prevent spread. An important but unproven approach is to have hospitals in a region coordinate surveillance and infection control measures. Using our Regional Healthcare Ecosystem Analyst (RHEA) simulation model and detailed Orange County, California, patient-level data on adult inpatient hospital and nursing home admissions (2011-2012), we simulated the spread of CRE throughout Orange County health-care facilities under 3 scenarios: no specific control measures, facility-level infection control efforts (uncoordinated control measures), and a coordinated regional effort. Aggressive uncoordinated and coordinated approaches were highly similar, averting 2,976 and 2,789 CRE transmission events, respectively (72.2% and 77.0% of transmission events), by year 5. With moderate control measures, coordinated regional control resulted in 21.3% more averted cases (n = 408) than did uncoordinated control at year 5. Our model suggests that without increased infection control approaches, CRE would become endemic in nearly all Orange County health-care facilities within 10 years. While implementing the interventions in the Centers for Disease Control and Prevention's CRE toolkit would not completely stop the spread of CRE, it would cut its spread substantially, by half

Microstructural asymmetry of the corticospinal tracts predicts right-left differences in circle drawing skill in right-handed adolescents

Most humans show a strong preference to use their right hand, but strong preference for the right hand does not necessarily imply a strong right–left asymmetry in manual proficiency (i.e., dexterity). Here we tested the hypothesis that intra-individual asymmetry of manual proficiency would be reflected in microstructural differences between the right and left corticospinal tract (CST) in a cohort of 52 right-handed typically-developing adolescents (11–16 years). Participants were asked to fluently draw superimposed circles with their right dominant and left non-dominant hand. Temporal regularity of circle drawing movements was assessed for each hand using a digitizing tablet. Although all participants were right-handed, there was substantial inter-individual variation regarding the relative right-hand advantage for fluent circle drawing. All subjects underwent whole-brain diffusion tensor imaging at 3 Tesla. The right and left CST were defined as regions-of-interest and mean fractional anisotropy (FA) and diffusivity values were calculated for right and left CST. On average, mean FA values were higher in the left CST relative to right CST. The degree of right–left FA asymmetry showed a linear relationship with right–left asymmetry in fluent circle drawing after correction for age and gender. The higher the mean FA values were in the left dominant CST relative to the right non-dominant CST, the stronger was the relative right-hand advantage for regular circle drawing. These findings show that right–left differences in manual proficiency are highly variable in right-handed adolescents and that this variation is associated with a right-left microstructural asymmetry of the CST

An adaptive hierarchical particle-mesh code with isolated boundary conditions

This article describes a new, fully adaptive Particle-Multiple-Mesh numerical simulation code developed primarily for simulations of small regions (such as a group of galaxies) in a cosmological context. It integrates the equations of motion of a set of particles subject to their mutual gravitational interaction and to an arbitrary external field. The interactions are computed using a hierarchy of nested grids constructed anew at each integration step to enhance the spatial resolution in high-density regions of interest. Significant effort has gone into supporting isolated boundary conditions at the top grid level. This makes our method also applicable to non-cosmological problems, at the cost of some complications which we discuss. We point out the implications of some differences between our approach and those of other authors of similar codes, in particular with respect to the handling of the interface between regions of different spatial resolution. We present a selection of tests performed to verify the correctness and performance of our implementation. The conclusion suggests possible further improvements in the areas of independent time steps and particle softening lengths.Comment: 35 pages, LaTeX, uses aaspp4.sty, 8 figures included ApJ, in press. Only modest changes from earlier posted versio

X-ray Imaging Spectroscopy of Abell 1835

We present detailed spatially-resolved spectroscopy results of the observation of Abell 1835 using the European Photon Imaging Cameras (EPIC) and the Reflection Grating Spectrometers (RGS) on the XMM-Newton observatory. Abell 1835 is a luminous ($10^{46}$ ergs ${s}^{-1}$), medium redshift ($z=0.2523$), X-ray emitting cluster of galaxies. The observations support the interpretation that large amounts of cool gas are present in a multi-phase medium surrounded by a hot ($kT_{e}$=8.2 keV) outer envelope. We detect O VIII Ly$\alpha$ and two Fe XXIV complexes in the RGS spectrum. The emission measure of the cool gas below $kT_{e}$=2.7 keV is much lower than expected from standard cooling-flow models, suggesting either a more complicated cooling process than simple isobaric radiative cooling or differential cold absorption of the cooler gas.Comment: 6 pages, 4 figures, Accepted by A&A letters, XMM issu

Temporary Bonding with Polydimethylglutarimide Based Lift Off Resist as a Layer Transfer Platform

Bonding of lift off resist (LOR) was performed to realize temporary wafer bonding without residue. Bonding process conditions such as spin speed, pre-bake temperature, and bonding temperature were optimized to obtain a large bonded area with high bond strength. Under optimized process conditions, a bonded area covering over 98% of the wafer surface, with a room temperature bond strength of nearly 5 J/m2 is achieved. During razor blade testing, fracture often occurs at the Si wafer. Moreover, debonding using an N-Methyl-2-pyrrolidone (NMP)-based solvent left the wafer surface extremely small amount of residue. Thus, the optimized bonding processed developed in this research is suitable for a clean temporary bonding process