Médecine interne: cours d'hématologie

SYL-2643 = fascicule 1 ;SYL-2644 = fascicule 2Année Académique 1976-1977 3ème tirage2ème Doctoratinfo:eu-repo/semantics/publishe

Hématologie

SYL-3178 = Fascicule 12 édition 3 tirage Année Académique 1978-19792me Doctoratinfo:eu-repo/semantics/published

Erythropoiesis in nephrectomized dogs [14]

SCOPUS: le.jinfo:eu-repo/semantics/publishe

Erythropoietic Activity in Plasma and Urine of Dogs After Bleeding

Active erythropoietic factor is demonstrated in plasma and urine of bled dogs. A very striking erythropoietic factor response is obtained when severe anemia is produced. Activity is partially destroyed by boiling and by prolonged storage in freezer. © 1959, SAGE Publications. All rights reserved.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Médecine interne :cours d'hématologie

SYL-4378 = Fascicule 22e et 4e doctorat en médecineinfo:eu-repo/semantics/publishe

The kidney and erythropoiesis

IT has been pointed out1,2 that, in the dog, bilateral nephrectomy abolishes erythropoiesis, and it was suggested that the kidney produces a factor stimulating red blood cell formation. The experimental result did not definitely exclude retention of some toxic substance that inhibits the erythropoiesis, since the nephrectomized animals were still uræmic (blood urea level at about 300 mgm. per cent) despite peritoneal dialysis. © 1958 Nature Publishing Group.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Hematologic disorders in renal failure

Anemia is a frequent complication of renal failure. As in anemias of other origin, the resulting tissular hypoxia is partially compensated by an increased production of 2,3 diphosphoglycerate in red cells, and a shift to the right of the oxygen hemoglobin dissociation curve. Two mechanisms are implicated in this anemia: increased hemolysis, and depressed production of red cells. Decreased production of erythropoietin is probably the cause of reduced erythropoiesis, but the role of uremic intoxication has not been unequivocally excluded. In the course of chronic hemodialysis, iron deficiency anemia, and occasionally hypersplenism, develop. It is noteworthy that blood requirements in anephric patients are 2 to 3 times greater than those of nonanephric hemodialyzed patients. Accordingly, bilateral nephrectomy should be restricted to carefully selected cases. At the present time, androgens seem to be the best treatment of renal anemia. Qualitative anomalies of platelets are the main factor responsible for uremic bleeding, and are corrected by hemodialysis.SCOPUS: re.jinfo:eu-repo/semantics/publishe

Disappearance of the erythropoietic factor from plasma of anæmic dogs after nephrectomy

IN previous communications it was shown that bilateral nephrectomy abolished erythropoiesis in the dog1,2, whereas ureter ligation did not impair erythropoiesis despite a similar state of intoxication and malnutrition3. From these observations as well as the demonstration by Jacobson et al.4 that an elevated erythropoietin-level was not obtained in hypoxic rats after nephrectomy, it was suggested that the kidney may be the site of production of one erythropoietic stimulating substance. © 1959 Nature Publishing Group.SCOPUS: ar.jinfo:eu-repo/semantics/publishe